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Article
Open AccessEthanol consumption in non-human primates alters plasma markers of bone turnover but not tibia architecture
Ethanol consumption is associated with positive, negative, and neutral effects on the skeletal system. Our previous work using a nonhuman primate model of voluntary ethanol consumption showed that chronic etha...
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Article
Open AccessDiverse functions associate with non-coding polymorphisms shared between humans and chimpanzees
Long-term balancing selection (LTBS) can maintain allelic variation at a locus over millions of years and through speciation events. Variants shared between species in the state of identity-by-descent, hereaft...
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Chapter and Conference Paper
EGRE: Calculating Enrichment Between Genomic Regions
Advances in high-throughput experimental assays have enabled large-scale studies of genome function, especially in the non-protein-coding regions of the genome. These non-coding regions play important roles in...
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Article
The influence of evolutionary history on human health and disease
Nearly all genetic variants that influence disease risk have human-specific origins; however, the systems they influence have ancient roots that often trace back to evolutionary events long before the origin o...
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Article
Open AccessFunctional annotation of rare structural variation in the human brain
Structural variants (SVs) contribute to many disorders, yet, functionally annotating them remains a major challenge. Here, we integrate SVs with RNA-sequencing from human post-mortem brains to quantify their d...
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Article
Open AccessGenome-wide enhancer annotations differ significantly in genomic distribution, evolution, and function
Non-coding gene regulatory enhancers are essential to transcription in mammalian cells. As a result, a large variety of experimental and computational strategies have been developed to identify cis-regulatory enh...
