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Article
Associations between olfactory dysfunction and cognition: a sco** review
Strong evidence suggests that olfactory dysfunction (OD) can predict additional neurocognitive decline in neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases. However, research exploring ...
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Article
Resting-state functional connectivity changes in older adults with sleep disturbance and the role of amyloid burden
Sleep and related disorders could lead to changes in various brain networks, but little is known about the role of amyloid β (Aβ) burden—a key Alzheimer’s disease (AD) biomarker—in the relationship between sle...
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Article
Open AccessAssociation of APOE e2 genotype with Alzheimer’s and non-Alzheimer’s neurodegenerative pathologies
The apolipoprotein E (APOE) gene contains both the major common risk variant for late onset Alzheimer’s disease (AD), e4, and the major neuroprotective variant, e2. Here we examine the association of APOE e2 w...
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Article
Single-subject classification of schizophrenia using event-related potentials obtained during auditory and visual oddball paradigms
In the search for the biomarkers of schizophrenia, event-related potential (ERP) deficits obtained by applying the classic oddball paradigm are among the most consistent findings. However, the single-subject c...
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Article
The MATRICS Consensus Cognitive Battery in Patients with Bipolar I Disorder
The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative was devised to identify a neurocognitive battery to be used in clinical trials targeting cognition in schizophr...
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Article
Modulatory Effects of Modafinil on Neural Circuits Regulating Emotion and Cognition
Modafinil differs from other arousal-enhancing agents in chemical structure, neurochemical profile, and behavioral effects. Most functional neuroimaging studies to date examined the effect of modafinil only on...
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Article
Circumstances Under Which Practice Does Not Make Perfect: A Review of the Practice Effect Literature in Schizophrenia and Its Relevance to Clinical Treatment Studies
In this article, we review the literature on practice effects in schizophrenia, an underappreciated confound in interpreting cognitive improvement in clinical trials. We first examine claims regarding first- a...
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Article
Episodic Memory in Schizophrenia
Episodic memory impairments in individuals with schizophrenia have been well documented in the literature. However, despite the abundance of findings, constituent cognitive, neural, behavioral, and genetic com...
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Article
A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia
Polymorphisms in a primate-specific isoform of K+ channel KCNH2 are associated with schizophrenia. This isoform induces a rapidly deactivating K+ current and high-frequency neuronal firing pattern. The disease-as...
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Article
Open AccessEndocannabinoids in Alzheimer's disease and their impact on normative cognitive performance: a case-control and cohort study
Neuropathological, animal, and cell culture studies point to a role for the body's own endogenous cannabinoids (eCBs) system in Alzheimer's disease (AD) pathology and treatment. To date, no published studies h...
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Article
Tolcapone Improves Cognition and Cortical Information Processing in Normal Human Subjects
Prefrontal cortical dopamine (DA) regulates various executive cognitive functions, including attention and working memory. Efforts to enhance prefrontal-related cognition, which have focused on catecholaminerg...
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Article
The G72/G30 Gene Complex and Cognitive Abnormalities in Schizophrenia
A recently discovered gene complex, G72/G30 (hereafter G72, but now termed DAOA), was found to be associated with schizophrenia and with bipolar disorder, possibly because of an indirect effect on NMDA neurotr...
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Article
Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics
Catechol-O-methyltransferase (COMT) is a gene involved in the degradation of dopamine and may both increase susceptibility to develop schizophrenia and affect neuronal functions involved in working memory. A c...
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Article
Erratum: Comparison of Cognitive Peformances During a Placebo Period and an Atypical Antipsychotic Treatment Period in Schizophrenia: Critical Examination of Confounds
Correction to: Neuropsychopharmacology (2003) 28, 1491–1500. doi: 10.1038/sj.npp.1300216 Following publication of the above paper, the author has identified an error on page 1494. The correct statement should ...
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Article
Comparison of Cognitive Performances During a Placebo Period and an Atypical Antipsychotic Treatment Period in Schizophrenia: Critical Examination of Confounds
Although previous studies report cognitive improvement following atypical antipsychotic administration in schizophrenia (SC), few placebo-controlled within-subject studies with examination of confounds (sympto...
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Protocol
Intermediate Cognitive Phenotypes Associated with Schizophrenia
The search for intermediate phenotypes to inform genetic studies of psychiatric disorders is never as productive and exciting as in neuropsychological studies, particularly those of schizophrenia. A variety of...
