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Chapter and Conference Paper
Simulating Individual-Based Models of Epidemics in Hierarchical Networks
Current mathematical modeling methods for the spreading of infectious diseases are too simplified and do not scale well. We present the Simulator of Epidemic Evolution in Complex Networks (SEECN), an efficient...
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Article
Open AccessIncreasing risk behaviour can outweigh the benefits of antiretroviral drug treatment on the HIV incidence among men-having-sex-with-men in Amsterdam
The transmission through contacts among MSM (men who have sex with men) is one of the dominating contributors to HIV prevalence in industrialized countries. In Amsterdam, the capital of the Netherlands, the MS...
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Article
Open AccessInformation dissipation as an early-warning signal for the Lehman Brothers collapse in financial time series
In financial markets, participants locally optimize their profit which can result in a globally unstable state leading to a catastrophic change. The largest crash in the past decades is the bankruptcy of Lehma...
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Article
Inferring epidemiological parameters from phylogenetic information for the HIV-1 epidemic among MSM
The HIV-1 epidemic in Europe is primarily sustained by a dynamic topology of sexual interactions among MSM who have individual immune systems and behavior. This epidemiological process shapes the phylogeny of ...
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Article
Towards understanding the behavior of physical systems using information theory
One of the goals of complex network analysis is to identify the most influential nodes, i.e., the nodes that dictate the dynamics of other nodes. In the case of autonomous systems or transportation networks, h...
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Article
Open AccessInferring causation from time series in Earth system sciences
The heart of the scientific enterprise is a rational effort to understand the causes behind the phenomena we observe. In large-scale complex dynamical systems such as the Earth system, real experiments are rar...
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Article
Open AccessGame of neutrophils: modeling the balance between apoptosis and necrosis
Neutrophils are one of the key players in the human innate immune system (HIIS). In the event of an insult where the body is exposed to inflammation triggering moieties (ITMs), neutrophils are mobilized toward...
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Chapter and Conference Paper
Early Signs of Critical Slowing Down in Heart Surface Electrograms of Ventricular Fibrillation Victims
Ventricular fibrillation (VF) is a dangerous type of cardiac arrhythmia which, without intervention, almost always results in sudden death. Implantable automatic defibrillators are among the most successful de...
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Chapter and Conference Paper
Detecting Critical Transitions in the Human Innate Immune System Post-cardiac Surgery
Coronary artery bypass grafting with cardiopulmonary bypass activates the human innate immune system (HIIS) and invokes a vigorous inflammatory response that is systemic. This massive inflammatory reaction ca...
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Article
Open AccessBridging the gap between complexity science and clinical practice by formalizing idiographic theories: a computational model of functional analysis
The past decades of research have seen an increase in statistical tools to explore the complex dynamics of mental health from patient data, yet the application of these tools in clinical practice remains uncom...
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Article
Open AccessQuestionnaire data analysis using information geometry
The analysis of questionnaires often involves representing the high-dimensional responses in a low-dimensional space (e.g., PCA, MCA, or t-SNE). However questionnaire data often contains categorical variables ...
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Article
Open AccessMap** the multicausality of Alzheimer’s disease through group model building
Alzheimer’s disease (AD) is a complex, multicausal disorder involving several spatiotemporal scales and scientific domains. While many studies focus on specific parts of this system, the complexity of AD is ra...
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Article
Open AccessEvaluating the performance of multivariate indicators of resilience loss
Various complex systems, such as the climate, ecosystems, and physical and mental health can show large shifts in response to small changes in their environment. These ‘tip** points’ are notoriously hard to ...
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Article
Open AccessUnderstanding the impact of exposure to adverse socioeconomic conditions on chronic stress from a complexity science perspective
Chronic stress increases chronic disease risk and may underlie the association between exposure to adverse socioeconomic conditions and adverse health outcomes. The relationship between exposure to such condit...
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Article
Open AccessUsing network analysis to identify leverage points based on causal loop diagrams leads to false inference
Network analysis is gaining momentum as an accepted practice to identify which factors in causal loop diagrams (CLDs)—mental models that graphically represent causal relationships between a system’s factors—ar...
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Chapter and Conference Paper
CrimeSeen: An Interactive Visualization Environment for Scenario Testing on Criminal Cocaine Networks
The resiliency of criminal networks against law enforcement interventions has driven researchers to investigate methods of creating accurate simulated criminal networks. Despite these efforts, insights reachin...
