26 Result(s)
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Filippo Castiglione
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Article
Open AccessForum on immune digital twins: a meeting report
Medical digital twins are computational models of human biology relevant to a given medical condition, which are tailored to an individual patient, thereby predicting the course of disease and individualized t...
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Chapter and Conference Paper
A Multi-Scale Immune System Simulator for the Onset of Type 2 Diabetes
Type 2 diabetes mellitus (T2D), the most common form of diabetes, is a chronic metabolic disorder characterized by hyperglycemia, insulin resistance, and insulin deficiency. Although genetic predisposition det...
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Article
Open AccessEmulating complex simulations by machine learning methods
The aim of the present paper is to construct an emulator of a complex biological system simulator using a machine learning approach. More specifically, the simulator is a patient-specific model that integrates...
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Article
Open AccessIn silico designing of vaccine candidate against Clostridium difficile
Clostridium difficile is a spore-forming gram-positive bacterium, recognized as the primary cause of antibiotic-associated nosocomial diarrhoea. Clostridium difficile infection (CDI) has emerged as a major health...
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Article
Open AccessPotential predictors of type-2 diabetes risk: machine learning, synthetic data and wearable health devices
The aim of a recent research project was the investigation of the mechanisms involved in the onset of type 2 diabetes in the absence of familiarity. This has led to the development of a computational model tha...
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Article
Open AccessA candidate multi-epitope vaccine against SARS-CoV-2
In the past two decades, 7 coronaviruses have infected the human population, with two major outbreaks caused by SARS-CoV and MERS-CoV in the year 2002 and 2012, respectively. Currently, the entire world is fac...
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Reference Work Entry In depth
Agent-Based Modeling and Simulation, Introduction to
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Living Reference Work Entry In depth
Agent Based Modeling and Simulation, Introduction to
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Article
Open AccessGame of neutrophils: modeling the balance between apoptosis and necrosis
Neutrophils are one of the key players in the human innate immune system (HIIS). In the event of an insult where the body is exposed to inflammation triggering moieties (ITMs), neutrophils are mobilized toward...
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Chapter and Conference Paper
Computing Hierarchical Transition Graphs of Asynchronous Genetic Regulatory Networks
In the field of theoretical biology the study of the dynamics of the so-called gene regulatory networks is useful to follow the relationship between the expression of a gene and its dynamic regulatory effect o...
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Article
Open AccessStatistical ensemble of gene regulatory networks of macrophage differentiation
Macrophages cover a major role in the immune system, being the most plastic cell yielding several key immune functions.
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Chapter and Conference Paper
Characterisation of the Idiotypic Immune Network Through Persistent Entropy
In the present work we intend to investigate how to detect the behaviour of the immune system reaction to an external stimulus in terms of phase transitions. The immune model considered follows Jerne’s idiotyp...
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Article
Open AccessThe hierarchical organization of natural protein interaction networks confers self-organization properties on pseudocells
Cell organization is governed and maintained via specific interactions among its constituent macromolecules. Comparison of the experimentally determined protein interaction networks in different model organism...
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Article
Open AccessVaccImm: simulating peptide vaccination in cancer therapy
Despite progress in conventional cancer therapies, cancer is still one of the leading causes of death in industrial nations. Therefore, an urgent need of progress in fighting cancer remains. A promising altern...
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Reference Work Entry In depth
Agent Based Modeling and Simulation, Introduction to
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Chapter
Computational Models as Novel Tools for Cancer Vaccines
Prevention of tumor growth by immunological approaches is based on the assumption that the immune system, if adequately stimulated before tumor onset, could be able to protect from specific cancers. In the las...
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Chapter
Comparing In Silico Results to In Vivo and Ex Vivo of Influenza-Specific Immune Responses After Vaccination or Infection in Humans
In this chapter we describe a computer simulation system focused on the immune response. The objective of this study is to show to what extent a computational model can be used as an in silico tool to compare alt...
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Article
Open AccessImmunological network signatures of cancer progression and survival
The immune contribution to cancer progression is complex and difficult to characterize. For example in tumors, immune gene expression is detected from the combination of normal, tumor and immune cells in the t...
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Article
Open AccessTimely HAART initiation may pave the way for a better viral control
When to initiate antiretroviral therapy in HIV infected patients is a diffcult clinical decision. Actually, it is still a matter of discussion whether early highly active antiretroviral therapy (HAART) during ...
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Article
Open AccessModeling lymphocyte homing and encounters in lymph nodes
The efficiency of lymph nodes depends on tissue structure and organization, which allow the coordination of lymphocyte traffic. Despite their essential role, our understanding of lymph node specific mechanisms...
