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Chapter and Conference Paper
Virtual Heart Models Help Elucidate the Role of Border Zone in Sustained Monomorphic Ventricular Tachycardia
Post-ischemic Ventricular Tachycardia (VT) is sustained by a depolarization wave re-entry through channel-like structures within the post-ischemic scar. These structures are usually formed by partially viable ...
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Article
Open AccessCinE caRdiac magneTic resonAnce to predIct veNTricular arrhYthmia (CERTAINTY)
Better models to identify individuals at low risk of ventricular arrhythmia (VA) are needed for implantable cardioverter-defibrillator (ICD) candidates to mitigate the risk of ICD-related complications. We des...
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Chapter and Conference Paper
Graph Convolutional Regression of Cardiac Depolarization from Sparse Endocardial Maps
Electroanatomic map** as routinely acquired in ablation therapy of ventricular tachycardia is the gold standard method to identify the arrhythmogenic substrate. To reduce the acquisition time and still provi...
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Chapter and Conference Paper
Early Signs of Critical Slowing Down in Heart Surface Electrograms of Ventricular Fibrillation Victims
Ventricular fibrillation (VF) is a dangerous type of cardiac arrhythmia which, without intervention, almost always results in sudden death. Implantable automatic defibrillators are among the most successful de...
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Article
Computationally guided personalized targeted ablation of persistent atrial fibrillation
Atrial fibrillation (AF)—the most common arrhythmia—significantly increases the risk of stroke and heart failure. Although catheter ablation can restore normal heart rhythms, patients with persistent AF who de...
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Article
Personalized virtual-heart technology for guiding the ablation of infarct-related ventricular tachycardia
Ventricular tachycardia (VT), which can lead to sudden cardiac death, occurs frequently in patients with myocardial infarction. Catheter-based radio-frequency ablation of cardiac tissue has achieved only modes...
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Article
Open AccessLocating Order-Disorder Phase Transition in a Cardiac System
To prevent sudden cardiac death, predicting where in the cardiac system an order-disorder phase transition into ventricular fibrillation begins is as important as when it begins. We present a computationally e...
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Article
A Computational Framework for Personalized Blood Flow Analysis in the Human Left Atrium
Atrial fibrillation (AF), the most common human arrhythmia, is a marker of an increased risk of embolic stroke. However, recent studies suggest that AF may not be mechanistically responsible for the stroke eve...
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Article
Origin of the Electrocardiographic U Wave: Effects of M Cells and Dynamic Gap Junction Coupling
The electrophysiological basis underlying the genesis of the U wave remains uncertain. Previous U wave modeling studies have generally been restricted to 1-D or 2-D geometries, and it is not clear whether the ...
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Chapter and Conference Paper
A Statistical Approach for Detecting Tubular Structures in Myocardial Infarct Scars
The presence of an infarct scar in the heart generates abnormal electrical pathways that may trigger the occurrence of arrhythmic episodes. While precise models of the electric propagation in the heart have be...
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Article
Geodesic Based Registration of Sensor Data and Anatomical Surface Image Data
This paper presents two related methods for registering an image of an anatomical object with data from sensors arranged on the object. One method is described with reference to a test case involving a rectang...
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Chapter and Conference Paper
Estimating Local Apparent Conductivity with a 2-D Electrophysiological Model of the Heart
In this article we study the problem of estimating the parameters of a 2-D electrophysiological model of the heart from a set of temporal recordings of extracellular potentials. The chosen model is the reactio...
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Chapter
Prospects for Gene Therapy for the Fibrosed Heart: Targeting Regulators of Extracellular Matrix Turnover
