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Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach
The daily renewal of the corpus epithelium is fuelled by adult stem cells residing within tubular glands, but the identity of these stem cells remains controversial. Lgr5 marks homeostatic stem cells and ‘rese...
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Article
Organoids as an in vitro model of human development and disease
Barker and colleagues review the history and recent developments of organoid cultures derived from pluripotent stem cells and adult epithelia, and discuss how the technology can be used for basic research as w...
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Article
Ovary and fimbrial stem cells: biology, niche and cancer origins
Cyclic rupture and repair of the ovarian surface epithelium during ovulation, and repeated exposure of the fimbrial epithelium to the mechanics of follicular r...
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Article
Lgr5 marks stem/progenitor cells in ovary and tubal epithelia
The ovary surface epithelium (OSE) undergoes ovulatory tear and remodelling throughout life. Resident stem cells drive such tissue homeostasis in many adult epithelia, but their existence in the ovary has not ...
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Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration
Intestinal stem cells are responsible for the remarkable ability of the intestinal epithelium to efficiently renew and repair itself throughout life.
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Stem cell reprogramming as a driver of basal cell carcinoma
Basal cell carcinoma has been shown to originate from activation of hedgehog signalling in interfollicular epidermal progenitor cells. Analyses of the early steps of basal cell carcinoma formation show that th...
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Dll1+ secretory progenitor cells revert to stem cells upon crypt damage
Notch signalling in the intestinal crypt is modulated to drive commitment to the secretory fate. Clevers and colleagues find that cells expressing the Notch ligand DLL1 are intermediate secretory cells that ca...
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p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice
K. Lenhard Rudolph and colleagues report that conditional p53 deletion in the intestinal epithelium of aging mice impaired the depletion of chromosomal-instable stem cells and shortened the lifespan of telomer...
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Lgr5 marks cycling, yet long-lived, hair follicle stem cells
Rune Toftgård and colleagues report that Lgr5, a G protein-coupled receptor recently identified as a marker of intestinal stem cells, marks a population of hair follicle stem cells that is actively proliferati...
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Article
The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression
The constitutive activation of β-catenin-dependent (‘canonical’) Wnt signalling is a necessary initiating event in the genesis of most colorectal cancers. As this constitutive activation occurs through genetic...
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Erratum: Mining the Wnt pathway for cancer therapeutics
Nature Reviews Drug Discovery 5, 997–1014 (2006); doi:10.1038/nrd2154 In Table 2b on page 1009, there is an error in the structure of the compound NSC668036. The correct structure is shown below.
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Mining the Wnt pathway for cancer therapeutics
Aberrant activation of the Wnt pathway is implicated in driving the formation of various human cancers, particularly those of the digestive tract.
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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
Mutations of the genes encoding APC or ß-catenin in colon carcinoma induce the constitutive formation of nuclear ß-catenin/Tcf-4 complexes, resulting in activated transcription of Tcf target genes1,2. To study th...