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  1. No Access

    Article

    The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

    Tcf/Lef transcription factors mediate signalling from Wingless/Wnt proteins by recruiting Armadillo/β-catenin as a transcriptional co-activator1,2,3,4,5,6,7. However, studies of Drosophila, Xenopus and Caenorhabd...

    Jeroen Roose, Miranda Molenaar, Josi Peterson, Jolanda Hurenkamp, Helen Brantjes… in Nature (1998)

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    Article

    Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

    Mutations of the genes encoding APC or ß-catenin in colon carcinoma induce the constitutive formation of nuclear ß-catenin/Tcf-4 complexes, resulting in activated transcription of Tcf target genes1,2. To study th...

    Vladimir Korinek, Nick Barker, Petra Moerer, Elly van Donselaar… in Nature Genetics (1998)

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    Article

    Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4

    A striking example of the relationship between regulation of transcription and phenotype is the central role of the Y-chromo-somal gene Sry in mammalian sex determination1,2. Sry is the founding member of a large...

    Marco W. Schilham, Mariëtte A. Oosterwegel, Petra Moerer, **g Ya… in Nature (1996)

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    Article

    Chromosome 4q DNA rearrangements associated with facioscapulohumeral muscular dystrophy

    Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant neuromuscular disorder which maps to chromosome 4qter, distal to the D4S139 locus. The cosmid clone 13E, isolated in a search for homeobox ge...

    Cisca Wijmenga, Jane E. Hewitt, Lodewijk A. Sandkuijl, Lorraine N. Clark… in Nature Genetics (1992)