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Publisher Correction: Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis
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Article
Correction to: Minimum intervention oral care - incentivising preventive management of high-needs/high caries-risk patients using phased courses of treatment
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Article
Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis
The circadian clock regulates daily rhythms of numerous physiological activities through tightly coordinated modulation of gene expression and biochemical functions. Circadian disruption is associated with enh...
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Article
Open AccessMinimum intervention oral care - incentivising preventive management of high-needs/high caries-risk patients using phased courses of treatment
This paper demonstrates how person-focused, prevention-based, risk/needs-related, team-delivered, minimum intervention oral care (MIOC) principles and approaches can be integrated into the dental profession fo...
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Article
Cell transcriptomic atlas of the non-human primate Macaca fascicularis
Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 mil...
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Article
A key malignant switch in skin SCC
The mechanisms regulating the progression of benign tumors to malignant carcinomas remain incompletely understood. A new study identifies the transcription factor NR2F2 as a specific regulator of this transiti...
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Article
AQP5 enriches for stem cells and cancer origins in the distal stomach
LGR5 marks resident adult epithelial stem cells at the gland base in the mouse pyloric stomach1, but the identity of the equivalent human stem cell population remains unknown owing to a lack of surface markers th...
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Open AccessNeonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development
Wnt signaling is critical for directing epithelial gland development within the uterine lining to ensure successful gestation in adults. Wnt-dependent, Lgr5-expressing stem/progenitor cells are essential for the ...
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Author Correction: RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6
In this Letter, the surname of author Lena Vlaminck was misspelled ‘Vlaeminck’. In addition, author Kris Vleminckx should have been associated with affiliation 16 (Center for Medical Genetics, Ghent University...
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Article
RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6
The four R-spondin secreted ligands (RSPO1–RSPO4) act via their cognate LGR4, LGR5 and LGR6 receptors to amplify WNT signalling1–3. Here we report an allelic series of recessive RSPO2 mutations in humans that cau...
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Digesting recent stem cell advances in the gut
2017 has witnessed major advances in gut stem cell and cancer stem cell research, delivering key insights into their regulation, more defined culture methods and novel stem cell markers that collectively drive...
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Role of Lgr5-Expressing Stem Cells in Epithelial Renewal and Cancer in the Reproductive Tract
The identification and molecular characterisation of somatic stem cells are pivotal to understanding the mechanisms of tissue development and homeostasis, as well as oncogenesis. The epithelia lining the femal...
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Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach
The daily renewal of the corpus epithelium is fuelled by adult stem cells residing within tubular glands, but the identity of these stem cells remains controversial. Lgr5 marks homeostatic stem cells and ‘rese...
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Open AccessInactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma
Melanoma patients treated with oncogenic BRAF inhibitors can develop cutaneous squamous cell carcinoma (cSCC) within weeks of treatment, driven by paradoxical RAS/RAF/MAPK pathway activation. Here we identify ...
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Organoids as an in vitro model of human development and disease
Barker and colleagues review the history and recent developments of organoid cultures derived from pluripotent stem cells and adult epithelia, and discuss how the technology can be used for basic research as w...
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Open AccessQuantifying Lgr5-positive stem cell behaviour in the pyloric epithelium
Using in-vivo lineage tracing data we quantified clonal expansion as well as proliferation and differentiation of the Lgr5-positive stem cell population in pyloric gastric glands. Fitting clone expansion models, ...
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Article
Ovary and fimbrial stem cells: biology, niche and cancer origins
Cyclic rupture and repair of the ovarian surface epithelium during ovulation, and repeated exposure of the fimbrial epithelium to the mechanics of follicular r...
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Article
Lgr5 marks stem/progenitor cells in ovary and tubal epithelia
The ovary surface epithelium (OSE) undergoes ovulatory tear and remodelling throughout life. Resident stem cells drive such tissue homeostasis in many adult epithelia, but their existence in the ovary has not ...
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Article
Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration
Intestinal stem cells are responsible for the remarkable ability of the intestinal epithelium to efficiently renew and repair itself throughout life.
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Stem cell reprogramming as a driver of basal cell carcinoma
Basal cell carcinoma has been shown to originate from activation of hedgehog signalling in interfollicular epidermal progenitor cells. Analyses of the early steps of basal cell carcinoma formation show that th...
