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  1. Article

    Author Correction: Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction

    A Correction to this paper has been published: https://doi.org/10.1038/s41556-021-00633-w.

    Tobias Sperka, Zhangfa Song, Yohei Morita… in Nature Cell Biology (2021)

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    Article

    USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity

    USP22, the deubiquitinating subunit of the SAGA transcriptional cofactor complex, is a member of an 11-gene “death-from-cancer” signature. USP22 has been considered an attractive therapeutic target since high ...

    Robyn Laura Kosinsky, Maria Zerche, Dominik Saul, **n Wang… in Cell Death & Differentiation (2020)

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    Article

    Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction

    p53 activates Puma-dependent apoptosis and p21-mediated cell-cycle arrest in response to DNA damage. Rudolph and colleagues show that stem-cell functionality in telomerase-deficient mice is improved by the del...

    Tobias Sperka, Zhangfa Song, Yohei Morita… in Nature Cell Biology (2012)

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    Article

    p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice

    K. Lenhard Rudolph and colleagues report that conditional p53 deletion in the intestinal epithelium of aging mice impaired the depletion of chromosomal-instable stem cells and shortened the lifespan of telomer...

    Yvonne Begus-Nahrmann, André Lechel, Anna C Obenauf… in Nature Genetics (2009)