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Open AccessDevelopment and validation of a smartphone-based deep-learning-enabled system to detect middle-ear conditions in otoscopic images
Middle-ear conditions are common causes of primary care visits, hearing impairment, and inappropriate antibiotic use. Deep learning (DL) may assist clinicians in interpreting otoscopic images. This study inclu...
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Determinants of incomplete vaccination in children at age two in France: results from the nationwide ELFE birth cohort
Incomplete vaccination in the pediatric population is a growing public health issue in high-income countries, but its determinants are poorly understood. Their identification is necessary to design target acti...
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Distinctive Features of Kawasaki Disease Following SARS-CoV-2 Infection: a Controlled Study in Paris, France
An outbreak of multisystem inflammatory syndrome in children, including Kawasaki disease (KD), emerged during COVID-19 pandemic. We explored whether Kawasaki-like disease (KD), when associated with confirmed S...
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Open AccessReporting studies on time to diagnosis: proposal of a guideline by an international panel (REST)
Studies on time to diagnosis are an increasing field of clinical research that may help to plan corrective actions and identify inequities in access to healthcare. Specific features of time to diagnosis studie...
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Enduring large use of acetaminophen suppositories for fever management in children: a national survey of French parents and healthcare professionals’ practices
The pharmacological specificities of the rectal formulation of acetaminophen led to a debate on its appropriateness for managing fever in children, but few data are available on the formulation’s current use a...
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Efficacy of colchicine in a child with relapsing bullous Henoch-Schönlein purpura
Colchicine is not usually considered a treatment option for cutaneous lesions of Henoch-Schönlein purpura (HSP) in children. We report a case of pediatric HSP with severe chronic and relapsing cutaneous manife...
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Open AccessRole of biomarkers in the management of antibiotic therapy: an expert panel review: I – currently available biomarkers for clinical use in acute infections
In the context of worldwide increasing antimicrobial resistance, good antimicrobial prescribing in more needed than ever; unfortunately, information available to clinicians often are insufficient to rely on. B...
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Open AccessRole of biomarkers in the management of antibiotic therapy: an expert panel review II: clinical use of biomarkers for initiation or discontinuation of antibiotic therapy
Biomarker-guided initiation of antibiotic therapy has been studied in four conditions: acute pancreatitis, lower respiratory tract infection (LRTI), meningitis, and sepsis in the ICU. In pancreatitis with susp...
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Interval between onset of symptoms and diagnosis of medulloblastoma in children: distribution and determinants in a population-based study
Hospital-based studies have reported long delays in the diagnosis of paediatric brain tumours. Our objective was to describe the duration between onset of symptoms and diagnosis of medulloblastoma in children ...
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Impressive renal damage after acute pyelonephritis in a child
Urinary tract infection (UTI) is one of the most common bacterial infections in children, and its role in the pathogenesis of scarred kidney is debated. We report on a 7-year-old child who presented with sever...
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Pertussis and respiratory syncytial virus infections
During the winter 2005–2006, all infants <4 months of age admitted for bronchiolitis or acute respiratory tract infection in a tertiary care pediatric hospital in Paris were tested for respiratory syncytial vi...
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Open AccessSelecting short-statured children needing growth hormone testing: Derivation and validation of a clinical decision rule
Numerous short-statured children are evaluated for growth hormone (GH) deficiency (GHD). In most patients, GH provocative tests are normal and are thus in retrospect unnecessary.
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The burden of respiratory viral disease in hospitalized children in Paris
A virus was identified in 464 out of 1,212 patients, 8 days to 16 years of age, who were admitted to the hospital in Paris during a 3 year period. Respiratory syncytial virus (RSV) was found in 428 patients, 7...
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Chorioretinal lesions as the unique feature of complete chronic granulomatous disease in an 8-year-old girl
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Rib fractures after chest physiotherapy for bronchiolitis or pneumonia in infants
Background. The reported causes of rib fractures in infants are: child abuse, accidental injury, cardiopulmonary resuscitation, bone fragility, birth trauma and severe cough.
