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Article
Open AccessDevelopment and validation of a smartphone-based deep-learning-enabled system to detect middle-ear conditions in otoscopic images
Middle-ear conditions are common causes of primary care visits, hearing impairment, and inappropriate antibiotic use. Deep learning (DL) may assist clinicians in interpreting otoscopic images. This study inclu...
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Article
Educational endoscopic videos improve teaching of middle ear anatomy
Videos and images are becoming an educational tool in every domain. The objective was to assess the contribution of short educational endoscopic videos in learning the complex anatomy of the tympanic cavity.
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Article
Experimental and Numerical Analysis of a PCM-Integrated Roof for Higher Thermal Performance of Buildings
Phase change materials (PCMs) designate materials able to store latent heat. PCMs change state from solid to liquid over a defined temperature range. This process is reversible and can be used for thermo-techn...
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Article
Open AccessHigher convergence of human-great ape enteric eukaryotic viromes in central African forest than in a European zoo: a One Health analysis
Human-animal pathogenic transmissions threaten both human and animal health, and the processes catalyzing zoonotic spillover and spillback are complex. Prior field studies offer partial insight into these proc...
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Article
Long-term outcomes of retrospective case series of middle ear implantation with Vibrant Soundbridge in children with congenital aural atresia
to assess audiological performance in quiet and noise, quality of life and side effects of Vibrant Soundbridge (VSB) in children with congenital aural atresia (CAA).
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Article
Impact of COVID-19 lockdown on a tertiary center pediatric otolaryngology emergency department
To assess the quantitative and qualitative impact of the COVID-19 lockdown on pediatric otolaryngology emergency activity. A retrospective study was conducted in a pediatric otolaryngology tertiary care center...
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Article
Open AccessSurgical techniques and functional evaluation for vestibular lesions in the mouse: unilateral labyrinthectomy (UL) and unilateral vestibular neurectomy (UVN)
Unilateral labyrinthectomy (UL) and unilateral vestibular neurectomy (UVN) are two surgical methods to produce vestibular lesions in the mouse. The objective of this study was to describe the surgical techniqu...
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Article
Open AccessA multi-disciplinary comparison of great ape gut microbiota in a central African forest and European zoo
Comparisons of mammalian gut microbiota across different environmental conditions shed light on the diversity and composition of gut bacteriome and suggest consequences for human and animal health. Gut bacteri...
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Article
Open AccessAutomated quantification of Epstein-Barr virus in whole blood for post-transplant lymphoproliferative disorders monitoring
Standardized and sensitive assays for Epstein Barr Virus (EBV) are needed to define universal cutoff for treatment initiation in allogeneic hematopoietic stem cells transplant recipients. In a context of accre...
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Article
Open AccessImmune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe
HBsAg immune-escape mutations can favor HBV-transmission also in vaccinated individuals, promote immunosuppression-driven HBV-reactivation, and increase fitness of drug-resistant strains. Stop-codons can enhan...
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Article
Author’s reply to “Letter to the editor on the article: Saccular measurements in routine MRI can predict hydrops in Menière’s disease by Simon F et al.”
This is an answer to the Letter to the Editor regarding our previously published article « Saccular measurements in routine MRI can predict hydrops in Menière’s disease ». We thank the authors for their intere...
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Article
Saccular measurements in routine MRI can predict hydrops in Menière’s disease
Most patients with suspicion of hydrops do not have access to MRI with 3D reconstruction of the endolymphatic space. Our main objective was to show that measurements of the saccule on a non-enhanced 3D-T2 MRI ...
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Article
The eukaryotic gut virome in hematopoietic stem cell transplantation: new clues in enteric graft-versus-host disease
Charles Chiu and colleagues analyze the gut viromes of recipients of hematopoietic stem cell transplantation and identify characteristics associated with the severity of graft-versus-host disease in the gut.
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Article
Open AccessMultiple HIV-1/M + HIV-1/O dual infections and new HIV-1/MO inter-group recombinant forms detected in Cameroon
Due to the prevalence of HIV-1 group M and the endemicity of HIV-1 group O infections in Cameroon, patients may be infected with both viruses and/or with HIV-1/MO recombinant forms. Such atypical infections m...
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Article
Open AccessShort-term spontaneous fluctuations of HBV DNA levels in a Senegalese population with chronic hepatitis B
We evaluated the short-term spontaneous fluctuations of HBV DNA and HBsAg levels in Senegalese patients with chronic infection with hepatitis B virus and normal ALT and determined factors related to these fluc...
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Article
Open AccessHigh level of susceptibility to human TRIM5α conferred by HIV-2 capsid sequences
HIV-2, which was transmitted to humans from a distant primate species (sooty mangabey), differs remarkably from HIV-1 in its infectivity, transmissibility and pathogenicity. We have tested the possibility that...
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Article
A new human immunodeficiency virus derived from gorillas
There are three established HIV-1 lineages, M, N and O, which arose after cross-species transmission of simian immunodeficiency virus circulating in chimpanzees. An unusual variant of HIV-1 has now been identi...
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Protocol
Quantification of Proviral DNA Load of Human Immunodeficiency Virus Type 2 Subtypes A and B Using Real-Time PCR
HIV-2 infection is confined mostly to West Africa. Seven HIV-2 subtypes have so far been described; only HIV-2 subtypes A and B are prevalent, the others being considered self-limiting infections at the epidem...
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Protocol
Plasma RNA Viral Load in HIV-1 Group O Infection by Real-Time PCR
HIV-1 group O strains are highly divergent, and are found mainly in central Africa. The clinical course of group O infection is identical to that of HIV-1 group M infection, with rapid onset of immunodeficienc...
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Chapter
Simian Immunodeficiency Viruses and the Origin of HIVs
Reconstruction of the phylogenetic relationships between the human lentiviruses responsible for the AIDS epidemic and lentiviruses from African nonhuman primates can help clarify the origin of the AIDS pandemi...
