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Article
Cancer cell-derived long pentraxin 3 (PTX3) promotes melanoma migration through a toll-like receptor 4 (TLR4)/NF-κB signaling pathway
Cutaneous melanoma is one of the most aggressive cancers characterized by a high plasticity, a propensity for metastasis, and drug resistance. Melanomas are composed of phenotypically diverse subpopulations of...
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Article
Open AccessHigh-dose methotrexate-based immuno-chemotherapy for elderly primary CNS lymphoma patients (PRIMAIN study)
To investigate immuno-chemotherapy for elderly immuno-competent patients (⩾65 years) with newly diagnosed primary central nervous system lymphoma, we conducted a multicentre single-arm trial. One cycle consist...
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Article
Strabologische und neuroophthalmologische Aspekte kindlicher Tumorerkrankungen
Die moderne Kinderonkologie erzielt durch eine stetige Optimierung der diagnostischen und therapeutischen Optionen wichtige Erfolge in der Versorgung von Kindern mit Krebserkrankungen. Im multidisziplinären Be...
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Article
The mutational pattern of primary lymphoma of the central nervous system determined by whole-exome sequencing
To decipher the mutational pattern of primary CNS lymphoma (PCNSL), we performed whole-exome sequencing to a median coverage of 103 × followed by mutation verification in 9 PCNSL and validation using Sanger se...
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Article
SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival
Aberrant expression of Secreted Protein Acidic and Rich in Cysteine (SPARC)/osteonectin has been associated with an invasive tumor cell phenotype and poor outcome in human melanomas. Although it is known that ...
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Article
Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma
Recent studies addressing the molecular characteristics of PCNSL, which is defined as malignant B-cell lymphoma with morphological features of DLBCL, have significantly improved our understanding of the pathog...
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Article
Ciglitazone negatively regulates CXCL1 signaling through MITF to suppress melanoma growth
We have previously demonstrated that the thiazolidinedione ciglitazone inhibited, independently of PPARγ activation, melanoma cell growth. Further investigations now show that ciglitazone effects are mediated thr...
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Article
Chromosomal imbalances and partial uniparental disomies in primary central nervous system lymphoma
To determine the pattern of genetic alterations in primary central nervous system lymphomas (PCNSL), 19 PCNSL were studied by high-density single-nucleotide polymorphism arrays. Recurrent losses involved 6p21....
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Article
The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCδ and proteasome-dependent regulation of Mcl-1 expression
B-cell chronic lymphocytic leukemia (B-CLL) is characterized by accumulation of mature monoclonal CD5+ B cells. The disease results mainly from a failure of cells to undergo apoptosis, a process largely influe...
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Article
Primäre ZNS-Lymphome
Primäre ZNS-Lymphome (PZNSL) gehören zu den seltenen Gehirntumoren. Sie machen etwa 3% aller primären intrakraniellen Neubildungen aus; das mediane Erkrankungsalter liegt zwischen 60 und 65 Jahren. PZNSL führe...
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Article
Hif-2alpha mediates UV-induced apoptosis through a novel ATF3-dependent death pathway
In this study, we describe a novel activating transcription factor 3 (ATF3)-dependent death pathway triggered by ultraviolet (UV) irradiation. We demonstrate that ATF3 contributes to UV-induced apoptosis throu...
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Article
Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell
To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by microarray-based gene expression profiling. Compariso...
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Article
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a
B-chronic lymphocytic leukemia (B-CLL) cell is characterized by the accumulation of long-lived CD5+ B lymphocytes, whose survival in vivo is in part dependent on exogenous factors such as cytokines and/or extrace...
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Article
Id3 is a novel regulator of p27kip1 mRNA in early G1 phase and is required for cell-cycle progression
P27kip is a key inhibitory protein of the cell-cycle progression, which is rapidly downregulated in early G1 phase by a post-translational mechanism involving the proteosomal degradation. In this study, using ...
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Article
Primäres ZNS-Lymphom während der Behandlung von Autoimmunerkrankungen mit Azathioprin
Wir berichten über eine 31-jährige Patientin, die nach immunsuppressiver Behandlung ein primäres Non-Hodgkin-Lymphom des Zentralnervensystems entwickelte. Zwei Jahre zuvor wurde bei der Patientin eine Colitis ...
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Article
A survey of the signaling pathways involved in megakaryocytic differentiation of the human K562 leukemia cell line by molecular and c-DNA array analysis
The K562 cell line serves as a model to study the molecular mechanisms associated with leukemia differentiation. We show here that cotreatment of K562 cells with PMA and low doses of SB202190 (SB), an inhibito...
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Chapter
The Immunological Synapse and Rho GTPases
Rho GTPases are molecular switches controlling a broad range of cellular processes including lymphocyte activation. Not surprisingly, Rho GTPases are now recognized as pivotal regulators of antigen-specific T ...
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Article
Primäre ZNS-Lymphome
Primäre ZNS-Lymphome (PCNSL) sind extranodale Non-Hodgkin-Lymphome (NHL), die primär im Hirnparenchym, seltener auch in den Leptomeningen und im hinteren Augenabschnitt wachsen. Eine systemische ...
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Chapter
Listeria monocytogenes: a Model System to Study Invasion and Spread of Bacteria in the Central Nervous System
Amongst the bacterial species that comprise the genus Listeria (L.), L. monocytogenes is the only one that is pathogenic for both humans and animals. As an asporogenous gram-positive rod, it is widely distributed...
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Article
New developments in the pathology of skull base tumors
As an anatomical interface between various tissues, the skull base harbors an exceptionally broad variety of neoplasms, some of which pose a major challenge for surgical pathology. The characterization of dis...
