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Article
Open AccessImprovement of functional outcome for patients with newly diagnosed grade 2 or 3 gliomas with co-deletion of 1p/19q – IMPROVE CODEL: the NOA-18 trial
Given the young age of patients with CNS WHO grade 2 and 3 oligodendrogliomas and the relevant risk of neurocognitive, functional, and quality-of-life impairment with the current aggressive standard of care tr...
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Article
Hirntumorimmuntherapie – Möglichkeiten und Herausforderungen der Personalisierung
Hirntumoren stellen eine besondere interdisziplinäre Herausforderung in der Behandlung neurologischer Erkrankungen dar. Einsichten in die interindividuelle sowie räumliche und zeitliche intraindividuelle Heter...
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Article
Open AccessDNA methylation, transcriptome and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development
Diffuse lower WHO grade II and III gliomas (LGG) are slowly progressing brain tumors, many of which eventually transform into a more aggressive type. LGG is characterized by widespread genetic and transcriptio...
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Article
Anästhesie zur Thrombektomie
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Article
NDRG1 prognosticates the natural course of disease in WHO grade II glioma
There is a lack of relevant prognostic and predictive factors in neurooncology besides mutation of isocitrate dehydrogenase 1, codeletion of 1p/19q and promoter hypermethylation of O ...
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Article
Biologische Grundlagen der Gehirnmetastasierung
Bestehende Gehirnmetastasen, aber auch die Sorge davor, künftig an ihnen zu erkranken, werden zunehmend zu einer Einschränkung der Lebensqualität bzw. -erwartung von Patienten mit soliden Tumoren.
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Zerebrale Metastasen
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Article
Personalisierte Neuroonkologie
Der Therapie hirneigener Tumoren steht ein fundamentaler Umbruch bevor. Dieser Umbruch wird aktuell weniger durch den Einsatz neuer zielgerichteter Therapien als durch die Definition molekularer Marker getrage...
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Article
A comprehensive analysis of vascular complications in 3,889 glioma patients from the German Glioma Network
Ischemic strokes, intracranial hemorrhages (ICH) and deep venous thromboembolism (DVT) are clinically important events in patients with gliomas. In this multicentre, noninterventional observational study, curr...
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Article
Suppression of proinvasive RGS4 by mTOR inhibition optimizes glioma treatment
An essential mode of acquired resistance to radiotherapy (RT) appears to be promotion of tumor cell motility and invasiveness in various cancer types, including glioblastoma, a process resembling ‘evasive resi...
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Article
Behandlung von Hirntumorpatienten
Obschon die Behandlung maligner Gliome mit modernen operativen und strahlentherapeutischen Verfahren, dem Einsatz alkylierender und antiangiogener Systemtherapie sowie ersten molekular basierten Therapieentsch...
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Article
Neuroradiological Response Criteria for High-grade Gliomas
The recently introduced new response criteria of the response assessment in neuro-oncology (RANO) working group and its clinical implications are the topic of this article. Establishing this working group as a...
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Article
Comment to: Parametric Response Map as an Imaging Biomarker to Distinguish Progression from Pseudoprogression in High-Grade Glioma: Pitfalls in Perfusion MRI in Brain Tumors
Pseudoprogression is a recently recognized phenomenon which occurs mainly within the first 3 months after resection and radiochemotherapy of glioblastomas in up to 30% of cases. It refers to contrast enhanceme...
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Arterial hypertension and bevacizumab treatment in glioblastoma: no correlation with clinical outcome
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Aryl hydrocarbon receptor inhibition downregulates the TGF-β/Smad pathway in human glioblastoma cells
The dioxin/aryl hydrocarbon receptor (AhR) is a transcription factor, which has been attributed a role in human cancerogenesis, cell cycle progression and transforming growth factor-β (TGF-β) signaling. As TGF...
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Article
Primäre ZNS-Lymphome
Primäre ZNS-Lymphome (PZNSL) gehören zu den seltenen Gehirntumoren. Sie machen etwa 3% aller primären intrakraniellen Neubildungen aus; das mediane Erkrankungsalter liegt zwischen 60 und 65 Jahren. PZNSL führe...
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Erratum: Adenoviral expression of XIAP antisense RNA induces apoptosis in glioma cells and suppresses the growth of xenografts in nude mice
Correction to: Gene Therapy (2007) 14, 147–161. doi:10.1038/sj.gt.3302845 Since the above publication, the authors have noticed that there are some errors in the western blots of Figures 1, 4, 6 and 7, which w...
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Article
Tryptophan degradation in autoimmune diseases
Recent evidence points to tryptophan (Trp) degradation as a potent immunosuppressive mechanism involved in the maintenance of immunological tolerance. Both Trp depletion and downstream Trp catabolites (TCs) ap...
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Article
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine
Methylating drugs such as temozolomide (TMZ) are widely used in the treatment of brain tumours (malignant gliomas). The mechanism of TMZ-induced glioma cell death is unknown. Here, we show that malignant gliom...
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Article
Adenoviral expression of XIAP antisense RNA induces apoptosis in glioma cells and suppresses the growth of xenografts in nude mice
The expression of inhibitor of apoptosis (IAP) family members contributes to the resistance of human cancers to apoptosis induced by radiotherapy and chemotherapy. We report that the infection of malignant gli...