45 Result(s)

Article

Chronophin is a glial tumor modifier involved in the regulation of glioblastoma growth and invasiveness

Glioblastoma is the most aggressive primary brain tumor in adults. Although the rapid recurrence of glioblastomas after treatment is a major clinical challenge, the relationships between tumor growth and intra...

M Schulze, O Fedorchenko, T G Zink, C B Knobbe-Thomsen, S Kraus, S Schwinn… in Oncogene (2016)

Article

Klassifikation von Gliomen

Die diagnostische Einteilung von Gliomen erfolgt traditionell histologisch auf Basis der Klassifikation der Weltgesundheitsorganisation (WHO) für Tumoren des zentralen Nervensystems. In den letzten Jahren wurd...

Dr. D. Capper, G. Reifenberger in Der Nervenarzt (2015)

Article

miRNA-145 is downregulated in atypical and anaplastic meningiomas and negatively regulates motility and proliferation of meningioma cells

Meningiomas are frequent, mostly benign intracranial or spinal tumors. A small subset of meningiomas is characterized by histological features of atypia or anaplasia that are associated with more aggressive bi...

N Kliese, P Gobrecht, D Pachow, N Andrae, A Wilisch-Neumann, E Kirches… in Oncogene (2013)

Article

Toxicity and survival in primary glioblastoma patients treated with concomitant plus adjuvant temozolomide versus adjuvant temozolomide: results of a single-institution, retrospective, matched-pair analysis

To compare survival and hematological toxicity rates between two postoperative therapy regimens in patients with primary glioblastoma (GBM), namely temozolomide (TMZ) concomitant to radiation, followed by adju...

A. Gutenberg, H. C. Bock, G. Reifenberger, W. Brück, A. Giese in Acta Neurochirurgica (2013)

Article

Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro

Deletions of chromosomal arms 1p and 19q are frequent in oligodendroglial tumours and linked to radio- and chemotherapy response as well as longer survival. The molecular mechanisms underlying this clinically ...

L M Dittmann, A Danner, J Gronych, M Wolter, K Stühler, M Grzendowski, N Becker… in Oncogene (2012)

Article

RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival

The concept of cancer stem-like cells (CSCs) has gained considerable attention in various solid tumors including glioblastoma, the most common primary brain tumor. This sub-population of tumor cells has been i...

V Goidts, J Bageritz, L Puccio, S Nakata, M Zapatka, S Barbus, G Toedt… in Oncogene (2012)

Article

De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures

All-trans retinoic acid is a potent promoter of cellular differentiation processes, which is used in cancer therapy. Glioblastoma spheroid cultures are enriched in tumor-initiating cells, and provide a model to t...

A Ernst, B Campos, J Meier, F Devens, F Liesenberg, M Wolter, G Reifenberger… in Oncogene (2010)

Chapter

Molecular neuropathology of low-grade gliomas and its clinical impact

The term “low-grade glioma” refers to a heterogeneous group of slowly growing glial tumors corresponding histologically to World Health Organization (WHO) grade I or II. This group includes astrocytic, oligode...

M. J. Riemenschneider, G. Reifenberger in Low-Grade Gliomas (2010)

Article

Hirnmetastasen

Die Resektion ist heute eine wichtige Säule in der Therapie von Hirnmetastasen. Die Operation selbst hat durch neue Technologien und bildgebende Verfahren ein hohes Maß an Sicherheit gewonnen. Durch prospektiv...

Prof. Dr. G. Schackert, J. Felsberg, G. Reifenberger, U. Schlegel in Der Onkologe (2008)

Article

Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell

To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by microarray-based gene expression profiling. Compariso...

M Montesinos-Rongen, A Brunn, S Bentink, K Basso, W K Lim, W Klapper… in Leukemia (2008)

Article

Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 in oligodendroglial tumours with allelic losses on 1p and 19q

Deletions of chromosomal arms 1p and 19q are frequent in oligodendroglial tumours and have been associated with sensitivity to radio- and chemotherapy as well as favourable prognosis. By using microarray-based...

B Tews, P Roerig, C Hartmann, M Hahn, J Felsberg, B Blaschke, M Sabel, A Kunitz… in Oncogene (2007)

Article

Frequent loss of chromosome 9, homozygous CDKN2A/p14^ARF/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas

The molecular pathogenesis of pleomorphic xanthoastrocytoma (PXA), a rare astrocytic brain tumor with a relatively favorable prognosis, is still poorly understood. We characterized 50 PXAs by comparative genom...

R G Weber, A Hoischen, M Ehrler, P Zipper, K Kaulich, B Blaschke, A J Becker… in Oncogene (2007)

Article

Niedriggradige Gliome

Die Gruppe der niedriggradigen Gliome umfasst zahlreiche, neuropathologisch differenzierbare Tumorentitäten, deren klinischer Verlauf weit weniger aggressiv als der von höhergradigen anaplastischen Gliomen und...

Prof. Dr. G. Schackert, M. Kirsch, C. B. Knobbe, G. Reifenberger… in Der Onkologe (2006)

Article

Supratentorial meningeal melanocytoma mimicking a convexity meningioma

Objective and importance. Meningeal melanocytomas are rare benign neuro-ectodermal tumors arising from melanocytic cells in the leptomeninges. These leptomeningeal melanocytes are found at highest density underne...

K. Beseoglu, C. B. Knobbe, G. Reifenberger, H.-J. Steiger… in Acta Neurochirurgica (2006)

Article

Evaluation of new ¹⁸F-labeled amino acids for brain PET

K. J. Langen, K. Hamacher, D. Pauleit, F. W. Floeth, G. Stoffels… in Anatomy and Embryology (2005)

Article

Expression of the CD34 antigen in pleomorphic xanthoastrocytomas

Pleomorphic xanthoastrocytoma (PXA) is a rare, superficially located astrocytic glioma of children and young adults, which is associated with a relatively favorable prognosis. Here we report on the expression ...

G. Reifenberger, K. Kaulich, O. D. Wiestler, I. Blümcke in Acta Neuropathologica (2003)

Article

Multimodal target point assessment for stereotactic biopsy in children with diffuse bithalamic astrocytomas

Introduction.Diffuse glial tumors with bithalamic involvement are rare in children. Diagnostic assessment can be difficult as the radiological findings can be unspecific.

A. Messing-Jünger, F. Floeth, D. Pauleit, G. Reifenberger… in Child’s Nervous System (2002)