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Article
Localization of Subsurface Defects in Uncoated Aluminum with Structured Heating Using High-Power VCSEL Laser Arrays
We report on photothermal detection of subsurface defects by coherent superposition of thermal wave fields. This is made possible by structured heating using high-power VCSEL laser arrays whose individual emit...
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Article
Increasing intensity of therapies assigned at diagnosis does not improve survival of adults with acute myeloid leukemia
We randomized 3375 adults with newly diagnosed acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome to test whether increasingly intensive chemotherapies assigned at study-entry and analyzed on a...
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Article
Antiviral function and efficacy of polyvalent immunoglobulin products against CMV isolates in different human cell lines
Primary infection and reactivation of human cytomegalovirus (CMV) remain a major problem in immunocompromised patients, frequently resulting in a life threatening CMV disease. Intravenous polyvalent (hyper)-im...
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Article
Open AccessClinical and molecular characterization of early T-cell precursor leukemia: a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutations
A subgroup of pediatric acute T-lymphoblastic leukemia (T-ALL) was characterized by a gene expression profile comparable to that of early T-cell precursors (ETPs) with a highly unfavorable outcome. We have inv...
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Article
Open AccessAntileukemic activity of the HSP70 inhibitor pifithrin-μ in acute leukemia
Heat shock protein (HSP) 70 is aberrantly expressed in different malignancies and has emerged as a promising new target for anticancer therapy. Here, we analyzed the in vitro antileukemic effects of pifithrin-μ (...
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Article
Genome-wide screen reveals WNT11, a non-canonical WNT gene, as a direct target of ETS transcription factor ERG
E26 transforming sequence-related gene (ERG) is a transcription factor involved in normal hematopoiesis and is dysregulated in leukemia. ERG mRNA overexpression was associated with poor prognosis in a subset of p...
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Article
BAALC-associated gene expression profiles define IGFBP7 as a novel molecular marker in acute leukemia
Over expression of BAALC (brain and acute leukemia, cytoplasmic) predicts an inferior outcome in acute myeloid leukemia (AML) and acute lymphoblastic leukemia patients. To identify BAALC-associated genes that giv...
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Article
Immune reconstitution and cytomegalovirus infection after allogeneic stem cell transplantation: the important impact of in vivo T cell depletion
We analyzed cytomegalovirus (CMV) infection risk factors and immune reconstitution kinetics in 89 patients after allogeneic stem cell transplantation (allo-SCT). The use of alemtuzumab for in vivo T cell deple...
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Article
Open AccessWeekly administration of sagopilone (ZK-EPO), a fully synthetic epothilone, in patients with refractory solid tumours: results of a phase I trial
Epothilones are a novel class of microtubule-stabilising agents, and sagopilone is a fully synthetic epothilone that has shown marked in vivo and in vitro preclinical activity.
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Article
Prophylactic i.v. Igs in patients with a high risk for CMV after allo-SCT
We developed a novel algorithm to define the need for high-dose prophylactic i.v. Igs (IVIG) in periods of high risk for CMV to patients after allo-SCT. IVIG were administered only if at least one of the follo...
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Article
Limited penetration of posaconazole into cerebrospinal fluid in an allogeneic stem cell recipient with invasive pulmonary aspergillosis
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Article
Treatment of primary mediastinal large B cell lymphoma with an alternating chemotherapy regimen based on high-dose methotrexate
Primary mediastinal large B cell lymphomas (MLCL) differ from other diffuse large cell lymphomas, leading to a description as a separate entity in the current World Health Organization classification. Dose int...
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Article
Primäre ZNS-Lymphome
Primäre ZNS-Lymphome (PZNSL) gehören zu den seltenen Gehirntumoren. Sie machen etwa 3% aller primären intrakraniellen Neubildungen aus; das mediane Erkrankungsalter liegt zwischen 60 und 65 Jahren. PZNSL führe...
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Article
Bendamustine, but not fludarabine, exhibits a low stem cell toxicity in vitro
We investigated the in vitro toxicity of bendamustine and fludarabine to hematopoietic progenitors and stem cells from healthy donors.
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Article
Combined automated cell and flow cytometric analysis enables recognition of persistent polyclonal B-cell lymphocytosis (PPBL), a study of 25 patients
Persistent polyclonal B-cell lymphocytosis (PPBL) is an extremely rare disorder, which occurs almost exclusively in smoking women and is characterized by a lymphocytosis with circulating binucleated lymphocyte...
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Article
Significance of gene expression analysis in uveal melanoma in comparison to standard risk factors for risk assessment of subsequent metastases
This study was undertaken to identify and compare the prognostic value of gene expression, chromosomal, and clinico-pathological data for the prediction of subsequent metastases in patients with primary uveal ...
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Article
Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group
Adult T-cell acute lymphoblastic leukemia (T-ALL) continues to represent an unfavorable disease. Molecularly based treatment stratifications could help improve outcome. The prognostic impact of HOX11 and HOX11...
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Article
Meningeosis neoplastica im Rahmen einer ZNS-Metastasierung
Die Meningeosis neoplastica (MN) ist eine disseminierte ZNS-Metastasierung solider Tumoren und weist eine besonders schlechte Prognose auf. Eine zeitnahe Diagnose ist häufig durch die sehr heterogene neurologi...
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Article
Kombinierte und sequenzielle systemische Chemotherapie und Strahlentherapie bei Hirnmetastasen
Die Strahlentherapie ist weiterhin Standardtherapie bei allen nichtoperablen Patienten mit Hirnmetastasen. Die systemische Chemotherapie kann v. a. bei Patienten mit chemotherapieempfindlichen Tumoren und akti...
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Article
Serotherapy with thymoglobulin and alemtuzumab differentially influences frequency and function of natural killer cells after allogeneic stem cell transplantation
Although thymoglobulin and alemtuzumab are frequently used in hematopoietic stem cell transplantation (HSCT), little is known of their effects on NK cells, which mediate important functions in post-transplanta...
