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Article
Open AccessMetastable CrMnNi steels processed by laser powder bed fusion: experimental assessment of elementary mechanisms contributing to microstructure, properties and residual stress
The complex thermal history imposed by the laser-based powder bed fusion of metals (PBF-LB/M) process is known to promote the evolution of unique microstructures. In the present study, metastable CrMnNi steels...
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Article
Open AccessEfficacy of AAV serotypes to target Schwann cells after intrathecal and intravenous delivery
To optimize gene delivery to myelinating Schwann cells we compared clinically relevant AAV serotypes and injection routes. AAV9 and AAVrh10 vectors expressing either EGFP or the neuropathy-associated gene GJB1/Co...
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Article
Ferromagnetism of the semi-simple cubic lattice
Heisenberg ferromagnet on a lattice with a low coordination number, \(Z=3\) Z ...
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Article
Open AccessEuropean LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia
The therapeutic landscape of chronic myeloid leukemia (CML) has profoundly changed over the past 7 years. Most patients with chronic phase (CP) now have a normal life expectancy. Another goal is achieving a st...
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Article
Additive Manufacturing of Co-Ni-Ga High-Temperature Shape Memory Alloy: Processability and Phase Transformation Behavior
Co-Ni-Ga high-temperature shape memory alloy is additively processed by selective laser melting for the first time. Reversible martensitic transformation of the as-built material is proven by differential scan...
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Article
Determinanten gesundheitsbezogener Lebensqualität bei systemischem Lupus erythematodes: eine monozentrische, retrospektive Langzeitobservationsstudie in Deutschland
Die Verbesserung der gesundheitsbezogenen Lebensqualität (HRQoL) ist ein übergeordnetes Behandlungsziel beim systemischen Lupus erythematodes (SLE). Patientendaten mit wiederholten HRQoL-Messungen aus unserer ...
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Article
Open AccessNon-coplanar Model States in Quantum Magnetism Applications of the High-Order Coupled Cluster Method
Coplanar model states for applications of the coupled cluster method (CCM) to problems in quantum magnetism are those in which all spins lie in a plane, whereas three-dimensional (3D) model states are, by cont...
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Article
Open AccessA functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety
Increased sympathetic noradrenergic signaling is crucially involved in fear and anxiety as defensive states. MicroRNAs regulate dynamic gene expression during synaptic plasticity and genetic variation of micro...
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Article
Eosinophilie bei pulmonalen Infektionen
Neben Allergien, Autoimmunerkrankungen, Vaskulitiden, Dermatosen, Malignomen und Medikamentennebenwirkungen können sowohl parasitäre als auch nichtparasitäre Infektionen Ursachen für eine Eosinophilie sein. Be...
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Article
Open AccessInterleukin 4 induces apoptosis of acute myeloid leukemia cells in a Stat6-dependent manner
Cytokines provide signals that regulate immature normal and acute myeloid leukemia (AML) cells in the bone marrow microenvironment. We here identify interleukin 4 (IL4) as a selective inhibitor of AML cell gro...
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Article
Differences between BCL2-break positive and negative follicular lymphoma unraveled by whole-exome sequencing
Depending on disease stage follicular lymphoma (FL) lack the t(14;18) in ~15–~50% of cases. Nevertheless, most of these cases express BCL2. To elucidate mechanisms triggering BCL2 expression and promoting path...
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Article
Accuracy of non-resonant laser-induced thermal acoustics (LITA) in a convergent–divergent nozzle flow
Non-resonant laser-induced thermal acoustics (LITA) was applied to measure Mach number, temperature and turbulence level along the centerline of a transonic nozzle flow. The accuracy of the measurement results...
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Article
Berufsbezogene Schmerzen und Schmerzmanagement im professionellen Sport
Als professionelle oder Berufssportler/innen werden diejenigen Athleten bezeichnet, die – abgesehen von einer hohen Trainings- und ggf. Wettkampfbelastung – zumindest teilweise und/oder vorübergehend ihren Leb...
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Article
GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder
The molecular genetics of panic disorder (PD) with and without agoraphobia (AG) are still largely unknown and progress is hampered by small sample sizes. We therefore performed a genome-wide association study ...
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Article
Open AccessNo increased prevalence of malignancies among first-degree relatives of 800 patients with chronic myeloid leukemia: a population-based study in Sweden
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Article
Open AccessSignatures of a magnetic field-induced unconventional nematic liquid in the frustrated and anisotropic spin-chain cuprate LiCuSbO4
Modern theories of quantum magnetism predict exotic multipolar states in weakly interacting strongly frustrated spin-1/2 Heisenberg chains with ferromagnetic nearest neighbor (NN) inchain exchange in high magn...
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Article
Open AccessIncreased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia
Recent studies suggest that a proportion of chronic myeloid leukemia (CML) patients in deep molecular remission can discontinue the tyrosine kinase inhibitor (TKI) treatment without disease relapse. In this mu...
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Article
Open AccessInactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma
Apart from its unique histopathological appearance with rare tumor cells embedded in an inflammatory background of bystander cells, classical Hodgkin lymphoma (cHL) is characterized by an unusual activation of...
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Article
Telerehabilitation nach Schlaganfall im häuslichen Umfeld
Die Nutzung moderner Informations- und Telekommunikationstechniken ermöglicht eine Telerehabilitation neurologischer Defizite im häuslichen Umfeld der Patienten. Die aktuelle Studienlage der rehabilitativen Te...
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Auswirkungen von Lupus auf das Blut
Ziel dieses Kapitels ist es, dass Sie nach dessen Lektüre 1. den verschiedenen Blutzellen ihre Funktion zuordnen können, 2. durch den Lupus verursachte oder davon unabhängige Ursachen für Veränderung der Blutz...
