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  1. No Access

    Article

    DOCK4 promotes loss of proliferation in glioblastoma progenitor cells through nuclear beta-catenin accumulation and subsequent miR-302-367 cluster expression

    Glioblastomas (GBM) are lethal primitive brain tumours characterized by a strong intra-tumour heterogeneity. We observed in GBM tissues the coexistence of functionally divergent micro-territories either enrich...

    D N Debruyne, L Turchi, F Burel-Vandenbos, M Fareh, F Almairac, V Virolle… in Oncogene (2018)

  2. No Access

    Article

    Fibronectin expression in glioblastomas promotes cell cohesion, collective invasion of basement membrane in vitro and orthotopic tumor growth in mice

    Glioblastoma multiforme (GBM) are highly invasive and angiogenic malignancies with a median survival time from diagnosis of <15 months. Previous work has revealed robust overexpression of fibronectin (FN) mRNA...

    E Serres, F Debarbieux, F Stanchi, L Maggiorella, D Grall, L Turchi… in Oncogene (2014)

  3. Article

    The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network

    Glioblastoma multiforme (GBM) is the most common form of primary brain tumor in adults, often characterized by poor survival. Glioma-initiating cells (GiCs) are defined by their extensive self-renewal, differe...

    M Fareh, L Turchi, V Virolle, D Debruyne, F Almairac… in Cell Death & Differentiation (2012)

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  4. Article

    ATF3 and p15PAF are novel gatekeepers of genomic integrity upon UV stress

    After genotoxic stress, normal cells trigger DNA repair or, if unable to repair, undergo apoptosis to eradicate the cells that bear the risk of becoming tumorigenic. Here we show that repression of the transcr...

    L Turchi, M Fareh, E Aberdam, S Kitajima, F Simpson… in Cell Death & Differentiation (2009)

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  5. Article

    Hif-2alpha mediates UV-induced apoptosis through a novel ATF3-dependent death pathway

    In this study, we describe a novel activating transcription factor 3 (ATF3)-dependent death pathway triggered by ultraviolet (UV) irradiation. We demonstrate that ATF3 contributes to UV-induced apoptosis throu...

    L Turchi, E Aberdam, N Mazure, J Pouysségur, M Deckert… in Cell Death & Differentiation (2008)

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  6. No Access

    Article

    Id3 is a novel regulator of p27kip1 mRNA in early G1 phase and is required for cell-cycle progression

    P27kip is a key inhibitory protein of the cell-cycle progression, which is rapidly downregulated in early G1 phase by a post-translational mechanism involving the proteosomal degradation. In this study, using ...

    A-A Chassot, L Turchi, T Virolle, G Fitsialos, M Batoz, M Deckert, V Dulic… in Oncogene (2007)