20 Result(s)

Article

Cost-effectiveness of two online interventions supporting self-care for eczema for parents/carers and young people

To estimate the cost-effectiveness of online behavioral interventions (EczemaCareOnline.org.uk) designed to support eczema self-care management for parents/carers and young people from an NHS perspective.

Tracey H. Sach, Mary Onoja, Holly Clarke… in The European Journal of Health Economics (2024)

Article

Two-by-two factorial randomised study within a trial (SWAT) to evaluate strategies for follow-up in a randomised prevention trial

Failure to collect outcome data in randomised trials can result in bias and loss of statistical power. Further evaluations of strategies to increase retention are required. We assessed the effectiveness of two...

Lucy E. Bradshaw, Alan A. Montgomery, Hywel C. Williams, Joanne R. Chalmers… in Trials (2020)

Article

Early aggressive intervention for infantile atopic dermatitis to prevent development of food allergy: a multicenter, investigator-blinded, randomized, parallel group controlled trial (PACI Study)—protocol for a randomized controlled trial

Atopic dermatitis is the first clinical manifestation of the atopic march, with the highest incidence in the first year of life. Those affected often go on to develop other allergic diseases including food all...

Kiwako Yamamoto-Hanada, Tohru Kobayashi… in Clinical and Translational Allergy (2018)

Article

Feasibility of weekly participant-reported data collection in a pragmatic randomised controlled trial in primary care: experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema)

Patient-reported outcomes measures in clinical trials ensure that evaluations of effectiveness focus on outcomes that are important to patients. In relapsing-remitting conditions, such as eczema, repeated meas...

Beth Stuart, Kate Rumsby, Miriam Santer, Matthew J. Ridd, Nick A. Francis… in Trials (2018)

Article

Development of a core outcome set for therapeutic clinical trials enrolling dogs with atopic dermatitis (COSCAD’18)

For decades, the efficacy of interventions in clinical trials enrolling dogs with atopic dermatitis (AD) relied on heterogeneous evaluations of skin lesions and pruritus using unvalidated tools. Although some ...

Thierry Olivry, Emmanuel Bensignor, Claude Favrot… in BMC Veterinary Research (2018)

Article

Effectiveness and cost-effectiveness of daily all-over-body application of emollient during the first year of life for preventing atopic eczema in high-risk children (The BEEP trial): protocol for a randomised controlled trial

Atopic eczema (AE) is a common skin problem that impairs quality of life and is associated with the development of other atopic diseases including asthma, food allergy and allergic rhinitis. AE treatment is a ...

Joanne R. Chalmers, Rachel H. Haines, Eleanor J. Mitchell, Kim S. Thomas… in Trials (2017)

Article

A multi-centre, parallel group superiority trial of silk therapeutic clothing compared to standard care for the management of eczema in children (CLOTHES Trial): study protocol for a randomised controlled trial

Eczema is a chronic, itchy skin condition that can have a large impact on the quality of life of patients and their families. People with eczema are often keen to try out non-pharmacological therapies like sil...

Eleanor F. Harrison, Rachel H. Haines, Fiona Cowdell, Tracey H. Sach… in Trials (2015)

Article

Achieving consensus over the assessment of clinical signs in eczema trials

Kim S Thomas, Jochen Schmitt, Phyllis I Spuls, Eric Simpson, Masutaka Furue… in Trials (2015)

Article

Validation of the global resource of eczema trials (GREAT database)

Eczema (syn. Atopic Eczema or Atopic Dermatitis) is a chronic, relapsing, itchy skin condition which probably results from a combination of genetic and environmental factors. The Global Resource of EczemA Tria...

Helen Nankervis, Alison Devine, Hywel C Williams, John R Ingram… in BMC Dermatology (2015)

Article

Key considerations for the experimental training and evaluation of cancer odour detection dogs: lessons learnt from a double-blind, controlled trial of prostate cancer detection

Cancer detection using sniffer dogs is a potential technology for clinical use and research. Our study sought to determine whether dogs could be trained to discriminate the odour of urine from men with prostat...

Kevin R Elliker, Barbara A Sommerville, Donald M Broom, David E Neal… in BMC Urology (2014)

Article

What determines patient preferences for treating low risk basal cell carcinoma when comparing surgery vs imiquimod? A discrete choice experiment survey from the SINS trial

The SINS trial (Controlled Clinical Trials ISRCTN48755084; Eudract No. 2004-004506-24) is a randomised controlled trial evaluating long term success of excisional surgery vs. imiquimod 5% cream for low risk no...

Michela Tinelli, Mara Ozolins, Fiona Bath-Hextall, Hywel C Williams in BMC Dermatology (2012)

Article

UK Dermatology Clinical Trials Network’s STOP GAP trial (a multicentre trial of prednisolone versus ciclosporin for pyoderma gangrenosum): protocol for a randomised controlled trial

Pyoderma gangrenosum (PG) is a rare inflammatory skin disorder characterised by painful and rapidly progressing skin ulceration. PG can be extremely difficult to treat and patients often require systemic immun...

Fiona F Craig, Kim S Thomas, Eleanor J Mitchell, Hywel C Williams, John Norrie… in Trials (2012)

Article

The value of the pragmatic-explanatory continuum indicator summary wheel in an ongoing study: the bullous pemphigoid steroids and tetracyclines study

The Pragmatic-Explanatory Continuum Indicator Summary (PRECIS) tool is intended to be used in the design phase of trials to help investigative teams design trials in-line with their purpose. Our team applied t...

Daniel J Bratton, Andrew J Nunn, Fenella Wojnarowska, Gudula Kirtschig… in Trials (2012)

Article

Map** randomized controlled trials of treatments for eczema - The GREAT database (The Global Resource of Eczema Trials: a collection of key data on randomized controlled trials of treatments for eczema from 2000 to 2010)

Massive duplication of effort occurs when researchers all over the world undertake extensive searches for randomized controlled trials when preparing systematic reviews, when develo** evidence-based guidelin...

Helen Nankervis, Alan Maplethorpe, Hywel C Williams in BMC Dermatology (2011)

Article

Validation of epidemiological tools for eczema diagnosis in brazilian children: the isaac's and uk working party's criteria

Instruments for field diagnosis of eczema are increasingly used, and it is essential to understand specific limitations to make best use of their strengths. Our objective was to assess the validity of ISAAC an...

Agostino Strina, Mauricio L Barreto, Sergio Cunha… in BMC Dermatology (2010)

Article

Problems in the reporting of acne clinical trials: a spot check from the 2009 Annual Evidence Update on Acne Vulgaris

In the course of producing the 2009 NHS Evidence - skin disorders Annual Evidence Update on Acne Vulgaris, 25 randomised controlled trials were examined. From these, at least 12 potentially serious problems of...

John R Ingram, Douglas JC Grindlay, Hywel C Williams in Trials (2010)

Article

The SINS trial: A randomised controlled trial of excisional surgery versus imiquimod 5% cream for nodular and superficial basal cell carcinoma

Basal cell carcinoma is the commonest human cancer. Despite increasing incidence it remains poorly researched. While not life threatening it can cause significant cosmetic disfigurement. Imiquimod, a cream whi...

Mara Ozolins, Hywel C Williams, Sarah J Armstrong, Fiona J Bath-Hextall in Trials (2010)

Article

Cars, CONSORT 2010, and Clinical Practice

Just like you would not buy a car without key information such as service history, you would not "buy" a clinical trial report without key information such as concealment of allocation. Implementation of the u...

Hywel C Williams in Trials (2010)

Article

Feasibility study to inform the design of a UK multi-centre randomised controlled trial of prophylactic antibiotics for the prevention of recurrent cellulitis of the leg

This paper describes the results of a feasibility study for a randomised controlled trial (RCT).

Kim S Thomas, Neil H Cox, Boki SP Savelyich, Debbie Shipley, Sarah Meredith… in Trials (2007)

Article

Introducing the National Library for Health Skin Conditions Specialist Library

This paper introduces the new National Library for Health Skin Conditions Specialist Library http://www.library.nhs.uk/skin.

Douglas Grindlay, Maged N Kamel Boulos, Hywel C Williams in BMC Dermatology (2005)