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Methodological innovations and stakeholder involvement in core outcome sets for skin diseases: a survey of the C3 working groups
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Clinical relevance and uptake of core outcome sets in dermatology
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Open AccessBurden of Hidradenitis Suppurativa: A Systematic Literature Review of Patient Reported Outcomes
Hidradenitis suppurativa (HS) has a profound negative impact on patients’ health-related quality of life (HRQoL). Here we summarize the evidence on HRQoL and Patient Reported Outcomes (PROs) in patients with H...
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Open AccessPatient Preferences in the Management of Hidradenitis Suppurativa: Results of a Multinational Discrete Choice Experiment in Europe
Hidradenitis suppurativa is a chronic inflammatory skin disease that can lead to a substantial reduction in quality of life. Recent studies revealed high levels of unmet care needs of patients with hidradeniti...
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Article
Adalimumab for Treating Moderate-to-Severe Hidradenitis Suppurativa: An Evidence Review Group Perspective of a NICE Single Technology Appraisal
As part of its single technology appraisal (STA) process, the UK National Institute for Health and Care Excellence (NICE) invited the manufacturer of adalimumab (AbbVie) to submit evidence on the clinical effe...
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Article
Open AccessPostprandial effects of a polyphenolic grape extract (PGE) supplement on appetite and food intake: a randomised dose-comparison trial
There is recent evidence that glucose delivered to the distal small intestine (SI) may stimulate the ileal brake and inhibit appetite. High polyphenolic grape extract (PGE) has been shown to inhibit α-amylase ...
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Open AccessValidation of the global resource of eczema trials (GREAT database)
Eczema (syn. Atopic Eczema or Atopic Dermatitis) is a chronic, relapsing, itchy skin condition which probably results from a combination of genetic and environmental factors. The Global Resource of EczemA Tria...
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Alitretinoina nell’eczema cronico grave alle mani. Valutazione di tecnologia singola presso il NICE
The National Institute for Health and Clinical Excellence (NICE) invited the manufacturer of alitretinoin (Basilea Pharmaceuticals Ltd, Basel, Switzerland) to submit evidence for the clinical and cost effectiv...
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Article
Ultradian rhythmicity and induced changes in salivary testosterone
Testosterone and cortisol respond to exercise stimuli and modulate adaptation. Episodic basal secretion of these hormones may modify the responsiveness of these hormones. We sought to identify episodic steroid...
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Open AccessProblems in the reporting of acne clinical trials: a spot check from the 2009 Annual Evidence Update on Acne Vulgaris
In the course of producing the 2009 NHS Evidence - skin disorders Annual Evidence Update on Acne Vulgaris, 25 randomised controlled trials were examined. From these, at least 12 potentially serious problems of...
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Article
Alitretinoin for Severe Chronic Hand Eczema
The National Institute for Health and Clinical Excellence (NICE) invited the manufacturer of alitretinoin (Basilea Pharmaceuticals Ltd, Basel, Switzerland) to submit evidence for the clinical and cost effectiv...
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Article
Mechanisms of Disease: nicotine—a review of its actions in the context of gastrointestinal disease
Smoking can have a detrimental and beneficial effect on gastrointestinal disease—it has such a 'polarizing effect' in patients with Crohn's disease and ulcerative colitis. Studies in tobacco smokers have made ...