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Article
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-a...
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Article
Open AccessImpact of PSA testing on secondary care costs in England and Wales: estimates from the Cluster randomised triAl of PSA testing for Prostate cancer (CAP)
Screening men for prostate cancer using prostate-specific antigen (PSA) testing remains controversial. We aimed to estimate the likely budgetary impact on secondary care in England and Wales to inform screenin...
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Article
Open AccessProstate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score
Prostate cancer risk stratification using single-nucleotide polymorphisms (SNPs) demonstrates considerable promise in men of European, Asian, and African genetic ancestries, but there is still need for increas...
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Article
Open AccessCost-Effectiveness Analysis of Prostate Cancer Screening in the UK: A Decision Model Analysis Based on the CAP Trial
Most guidelines in the UK, Europe and North America do not recommend organised population-wide screening for prostate cancer. Prostate-specific antigen-based screening can reduce prostate cancer-specific morta...
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Article
Open AccessThe architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates
Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal prostate predisposing to cancer development. In the prese...
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Article
A comparative study of peri-operative outcomes for 100 consecutive post-chemotherapy and primary robot-assisted and open retroperitoneal lymph node dissections
To describe and compare differences in peri-operative outcomes of robot-assisted (RA-RPLND) and open (O-RPLND) retroperitoneal lymph node dissection performed by a single surgeon where chemotherapy is the stan...
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Article
Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer
Polygenic hazard scores (PHS) can identify individuals with increased risk of prostate cancer. We estimated the benefit of additional SNPs on performance of a previously validated PHS (PHS46).
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Article
Open AccessKLK3 SNP–SNP interactions for prediction of prostate cancer aggressiveness
Risk classification for prostate cancer (PCa) aggressiveness and underlying mechanisms remain inadequate. Interactions between single nucleotide polymorphisms (SNPs) may provide a solution to fill these gaps. ...
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Article
Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
A Correction to this paper has been published: https://doi.org/10.1038/s41588-021-00786-2.
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Article
Open AccessPolygenic hazard score is associated with prostate cancer in multi-ethnic populations
Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis...
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Article
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studie...
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Article
Open AccessThe ProtecT randomised trial cost-effectiveness analysis comparing active monitoring, surgery, or radiotherapy for prostate cancer
There is limited evidence relating to the cost-effectiveness of treatments for localised prostate cancer.
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Article
Author Correction: The evolutionary history of lethal metastatic prostate cancer
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessIndependence of HIF1a and androgen signaling pathways in prostate cancer
Therapeutic targeting of the androgen signaling pathway is a mainstay treatment for prostate cancer. Although initially effective, resistance to androgen targeted therapies develops followed by disease progres...
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Article
Open AccessSystematic review and meta-analysis of the associations between body mass index, prostate cancer, advanced prostate cancer, and prostate-specific antigen
The relationship between body mass index (BMI) and prostate cancer remains unclear. However, there is an inverse association between BMI and prostate-specific antigen (PSA), used for prostate cancer screening....
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Article
Open AccessPublisher Correction: Shared heritability and functional enrichment across six solid cancers
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
In the version of this article initially published, the name of author Manuela Gago-Dominguez was misspelled as Manuela Gago Dominguez. The error has been corrected in the HTML and PDF version of the article.
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Article
Open AccessA reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer
Elucidation of mechanisms underlying the increased androgen receptor (AR) activity and subsequent development of aggressive prostate cancer (PrCa) is pivotal in develo** new therapies. Using a systems biolog...
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Article
Open AccessShared heritability and functional enrichment across six solid cancers
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types ba...
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Article
Open AccessAuthor Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry
The original version of this Article contained an error in the spelling of the author Manuela Gago-Dominguez, which was incorrectly given as Manuela G. Dominguez. This has now been corrected in both the PDF an...
