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Article
Epidemiological characterization of clinical isolates of meticillin resistant Staphylococcus aureus through multilocus sequence ty** and staphylococcal cassette chromosome mec ty** in Northwest Iran
Methicillin-resistant Staphylococcus aureus (MRSA), is considered a potential and aggressive nosocomial pathogen. It accounts for 50% of S. aureus isolates in tertiary hospitals in Iran, however, there is no suff...
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Article
Open AccessOccurrence of some common carbapenemase genes in carbapenem-resistant Klebsiella pneumoniae isolates collected from clinical samples in Tabriz, northwestern Iran
This study aimed to evaluate the antibiotic resistance patterns and prevalence of carbapenemase genes in Klebsiella pneumoniae isolates in different clinical samples from Tabriz city, northwestern Iran.
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Article
Open AccessCRISPR–Cas system to discover host-virus interactions in Flaviviridae
The Flaviviridae virus family members cause severe human diseases and are responsible for considerable mortality and morbidity worldwide. Therefore, researchers have conducted genetic screens to enhance insigh...
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Article
Open AccessSARS-CoV-2-associated organs failure and inflammation: a focus on the role of cellular and viral microRNAs
SARS-CoV-2 has been responsible for the recent pandemic all over the world, which has caused many complications. One of the hallmarks of SARS-CoV-2 infection is an induced immune dysregulation, in some cases r...
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Article
Immune-checkpoint expression in antigen-presenting cells (APCs) of cytomegaloviruses infection after transplantation: as a diagnostic biomarker
Cytomegalovirus (CMV), a member of the Herpesviridae family, mostly causes only slight feverish symptoms or can be asymptomatic in immunocompetent individuals. However, it is known to be particularly a significan...
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Article
PBMC MicroRNAs: Promising Biomarkers for the Differential Diagnosis of COVID-19 Patients with Abnormal Coagulation Indices
MicroRNAs, or miRNAs, may involve in coagulation and inflammation pathways caused by severe Coronavirus disease (COVID-19). Accordingly, this attempt was made to explore the behavior of peripheral blood mononu...
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Article
Effect of Caffeine Consumption on Cardiovascular Disease: An Updated Review
The incidence of cardiovascular diseases has significantly increased with the expansion of the industrialization of societies, which is notably linked to lifestyle changes and an unhealthy diet. Hence, determi...
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Article
Open AccesssiRNA-E6 sensitizes HPV-16-related cervical cancer through Oxaliplatin: an in vitro study on anti-cancer combination therapy
Persistent infection with high-risk Human papillomaviruses (HPV), such as hr-HPV-16 and hr-HPV-18, lead to cervical cancer, the fourth most common cancer in the world. In the present study, we investigated the...
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Article
Open AccessA comprehensive review of COVID-19 symptoms and treatments in the setting of autoimmune diseases
After the first reporting of the index case of Severe Acute Respiratory Syndrome (SARS)-CoV-2-associated disease at the end of December 2019, the virus spread quickly throughout the world, prompting the WHO on...
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Chapter
Gallbladder Cancer: Current Treatment Options and Therapeutics
Although rare, gallbladder cancer (GBC), a tumor of the biliary tract is characterized by high aggressiveness and invasiveness. Surgical resection of the tumor remains the most curative treatment approach; how...
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Article
SARS-CoV-2: Receptor and Co-receptor Tropism Probability
The recent pandemic which arose from China, is caused by a pathogenic virus named “severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2)”. Its rapid global expansion has inflicted an extreme pub...
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Chapter
Virus, Exosome, and MicroRNA: New Insights into Autophagy
Autophagy is known as a conserved self-eating mechanism that contributes to cells to degrade different intracellular components (i.e., macromolecular complexes, aggregated proteins, soluble proteins, organelle...
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Article
Open AccessPossible role of HPV/EBV coinfection in anoikis resistance and development in prostate cancer
This study aimed to evaluate the possible role of human papillomavirus (HPV) and Epstein–Barr virus (EBV) coinfection as an etiological factor for prostate cancer (PCa) development.
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Article
The roles of signaling pathways in SARS-CoV-2 infection; lessons learned from SARS-CoV and MERS-CoV
The number of descriptions of emerging viruses has grown at an unprecedented rate since the beginning of the 21st century. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus di...
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Article
Bacteriophages: cancer diagnosis, treatment, and future prospects
Early diagnosis is one of the most important factors in cancer treatment. Unfortunately, despite remarkable advances in the diagnosis and treatment methods of cancers in recent years, these methods are far fro...
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Article
Role of microRNAs in epidermal growth factor receptor signaling pathway in cervical cancer
Cervical cancer is one of the most common disorders in females all around the world. Similar to other types of cancer, several signaling pathways are demonstrated to be involved in the progression of this canc...
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Article
Non-alcoholic fatty liver diseases: from role of gut microbiota to microbial-based therapies
Non-alcoholic fatty liver disease (NAFLD) is the well-known disease of the liver in adults and children throughout the world. The main manifestations related to NAFLD are an unusual storage of lipid in hepatoc...
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Article
Open AccessPregnancy after mumps: a case report
Oophoritis, a complication of mumps, is said to affect only 5% of all postpubertal women. In this report, we present a case of a 31-year-old Iranian woman with amenorrhea and infertility due to an infantile ut...
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Article
Viral infection and atherosclerosis
Several risk factors have been described for the pathogenesis of atherosclerosis. Infectious diseases are suggested to be a causative factor, and some viruses have been studied for their relation with atherosc...
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Article
Open AccessHuman papillomavirus E5 protein, the undercover culprit of tumorigenesis
Human papillomavirus (HPV) is the most common viral infection of the reproductive tract worldwide. It has been well documented that the HPV oncoproteins E6 and E7 play important roles in cancer progression and...