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Effect of Caffeine Consumption on Cardiovascular Disease: An Updated Review

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Abstract

The incidence of cardiovascular diseases has significantly increased with the expansion of the industrialization of societies, which is notably linked to lifestyle changes and an unhealthy diet. Hence, determining the healthiest diet habits and supplements seems to be an appropriate way to decrease the global burden of cardiovascular diseases. Currently, caffeine, one of the most widely consumed compounds in the world, has emerged with some promising results in the treatment of numerous pathophysiological conditions of cardiovascular diseases. A literature search was conducted in PubMed, Scopus, Science Direct, Google Scholar, and Web of Science databases for the relevant articles regarding the pharmacology, preclinical, and clinical studies on the potential effects of caffeine on cardiovascular diseases. While caffeine could improve cardiovascular outcomes through several mechanisms of action, the literature review revealed controversial clinical effects of caffeine on blood pressure, cardiac arrhythmias, acute coronary syndrome, stable angina, and heart failure. In the case of dyslipidemia, coffee consumption increased total cholesterol, triglyceride, and low-density lipoprotein. Taken together, the existence of multiple confounding factors in the caffeine studies has resulted in inconclusive data interpretation. Further well-designed studies with adequate control of the confounding factors are warranted to draw a clear conclusion on the cardiovascular efficacy and safety of caffeine.

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Authors and Affiliations

  1. Department of Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Daneshgah St, Tabriz, Iran

    Sajad Khiali, Amin Agabalazadeh & Taher Entezari-Maleki

  2. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

    Sajad Khiali, Amin Agabalazadeh & Hadi Sahrai

  3. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Hossein Bannazadeh Baghi

  4. Department of Pediatrics, Faculty of Medicine, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran

    Gholamreza Rahbari Banaeian

  5. Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Taher Entezari-Maleki

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Khiali, S., Agabalazadeh, A., Sahrai, H. et al. Effect of Caffeine Consumption on Cardiovascular Disease: An Updated Review. Pharm Med 37, 139–151 (2023). https://doi.org/10.1007/s40290-023-00466-y

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