5,715 Result(s)
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Guo-**n Li
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Article
Open AccessNonlinear spatiotemporal characteristics of wind–rain flow around the trains passing through the tunnel entrance during rainstorms
Tropical storms present a significant risk to the safety of high-speed trains due to the extreme wind and rainfall they bring. This study employs Eulerian multiphase and Shear-Stress Transport k-ω turbulence mode...
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A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
Influenza A virus (IAV) is a widespread pathogen that poses a significant threat to human health, causing pandemics with high mortality and pathogenicity. Given the emergence of increasingly drug-resistant str...
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Phylogenomics, divergence times and notes of orders in Basidiomycota
Basidiomycota is one of the major phyla in the fungal tree of life. The outline of Basidiomycota provides essential taxonomic information for researchers and workers in mycology. In this study, we present a ti...
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Open AccessEpigenetic maintenance of adult neural stem cell quiescence in the mouse hippocampus via Setd1a
Quiescence, a hallmark of adult neural stem cells (NSCs), is required for maintaining the NSC pool to support life-long continuous neurogenesis in the adult dentate gyrus (DG). Whether long-lasting epigenetic ...
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Navβ2 Intracellular Fragments Contribute to Aβ1-42-Induced Cognitive Impairment and Synaptic Deficit Through Transcriptional Suppression of BDNF
A pathological hallmark of Alzheimer’s disease (AD) is the region-specific accumulation of the amyloid-beta protein (Aβ), which triggers aberrant neuronal excitability, synaptic impairment, and progressive cog...
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Boosting Stability and Efficiency: Defect-Rich Pd/NC Catalysts for Nitric Acid Reduction to Methyl Nitrite
Reduction of nitric acid reaction (2NO + HNO3 + 3CH3OH → 3CH3ONO + 2H2O) can convert by-product nitric acid into raw material methyl nitrite in the coal to ethylene glycol (CTEG) technology. This not only realize...
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Open AccessEasily misdiagnosed X-linked adrenoleukodystrophy
Addison’s disease and X-linked adrenoleukodystrophy (X-ALD) (Addison’s-only) are two diseases that need to be identified. Addison’s disease is easy to diagnose clinically when only skin and mucosal pigmentatio...
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A Novel Analysis Approach of Uniform Persistence for an Epidemic Model with Quarantine and Standard Incidence Rate
Inspired by the transmission characteristics of the Coronavirus disease 2019 (COVID-19), an epidemic model with quarantine and standard incidence rate is first developed, then a novel analysis approach is prop...
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Decreasing mitochondrial fission ameliorates HIF-1α-dependent pathological retinal angiogenesis
Angiogenesis plays a critical role in many pathological processes, including irreversible blindness in eye diseases such as retinopathy of prematurity. Endothelial mitochondria are dynamic organelles that unde...
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Machine Learning: A Potential Therapeutic Tool to Facilitate Neonatal Therapeutic Decision Making
Bacterial infection is one of the major causes of neonatal morbidity and mortality worldwide. Finding rapid and reliable methods for early recognition and diagnosis of bacterial infections and early individual...
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Article
An autonomous positioning method for fire robots with multi-source sensors
The present technology, based on laser and visual SLAM navigation and positioning, does not apply to the event of a fire in a room where there is a large amount of smoke, for its increasingly obvious defects. ...
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Article
Optical and electrical anisotropy regulation engineering of low-dimensional materials toward polarized detection and imaging applications
Polarized-sensitive image sensors are a kind of photodetector with great development potential due to their enhanced ability to detect and identify the target objects from the aspect of spatial, spectral and p...
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Open AccessTargeting delivery of miR-146a via IMTP modified milk exosomes exerted cardioprotective effects by inhibiting NF-κB signaling pathway after myocardial ischemia-reperfusion injury
Reperfusion therapy is critical for saving heart muscle after myocardial infarction, but the process of restoring blood flow can itself exacerbate injury to the myocardium. This phenomenon is known as myocardi...
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Ha-gnn: a novel graph neural network based on hyperbolic attention
Graph neural networks (GNNs) are powerful tools for data mining on graph-structured data in various domains, such as social science, finance, and biology. However, most existing GNNs operate in Euclidean space...
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Article
Design and fabrication of lightweight AlCrFeNiTix compositionally complex alloys with exceptional specific strength
This study focuses on compositionally complex alloys (CCAs), aiming to achieve a balance between high strength and low density for new energy and aerospace applications. The composition of AlCrFeNiTix CCAs is str...
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Article
Multiple Skew-Orthogonal Polynomials and 2-Component Pfaff Lattice Hierarchy
In this paper, we introduce multiple skew-orthogonal polynomials and investigate their connections with classical integrable systems. By using Pfaffian techniques, we show that multiple skew-orthogonal polynom...
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Open AccessA pan-KRAS degrader for the treatment of KRAS-mutant cancers
KRAS mutations are highly prevalent in a wide range of lethal cancers, and these mutant forms of KRAS play a crucial role in driving cancer progression and conferring resistance to treatment. While there have bee...
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Alterations in Serum Lipids and Lipoproteins Induced by Neoadjuvant Chemotherapy in Patients with Osteosarcoma around the Knee Joint: A Retrospective Analysis
To investigate the serum lipid profiles of patients with localized osteosarcoma around the knee joint before and after neoadjuvant chemotherapy.
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Characteristics of secondary microseisms generated in the Bohai Sea and their impact on seismic noise
In this study, we use the Bohai Sea area as an example to investigate the characteristics of secondary microseisms and their impact on seismic noise based on the temporal frequency spectral analysis of observa...
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Open AccessLocalized, highly efficient secretion of signaling proteins by migrasomes
Migrasomes, enriched with signaling molecules such as chemokines, cytokines and angiogenic factors, play a pivotal role in the spatially defined delivery of these molecules, influencing critical physiological ...
