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Article
Roles and Mechanisms of miRNAs in Abdominal Aortic Aneurysm: Signaling Pathways and Clinical Insights
Abdominal aortic aneurysm refers to a serious medical condition that can cause the irreversible expansion of the abdominal aorta, which can lead to ruptures that are associated with up to 80% mortality. Curren...
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Article
Open AccessThe abnormalities of free fatty acid metabolism in patients with hypertrophic cardiomyopathy, a single-center retrospective observational study
Previous studies have shown the importance of energy deficiency and malfunctioning mitochondria in the pathophysiology of hypertrophic cardiomyopathy (HCM). There has been a little research into the relationsh...
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Article
Open AccessTargeting SUMOylation with an injectable nanocomposite hydrogel to optimize radiofrequency ablation therapy for hepatocellular carcinoma
Incomplete radiofrequency ablation (iRFA) in hepatocellular carcinoma (HCC) often leads to local recurrence and distant metastasis of the residual tumor. This is closely linked to the development of a tumor im...
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Article
Open AccessCTR > 0.7 predicts the subgroup of lung adenocarcinomas ≤ 2 cm at risk of poor outcome treated by sublobar resection compared to lobar resection
A standard surgical procedure for patients with small early-stage lung adenocarcinomas remains unknown. Hence, we aim in this study to assess the clinical utility of the consolidation-to-tumor ratio (CTR) when...
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Article
Influence of Opening Penetration Ratio on Mechanical Behavior and Fracture Characteristics of Sandstone Rock: Experimental and Numerical Studies
The natural non-penetrated openings in natural rock masses due to weathering and erosion and the artificial non-penetrated openings formed in deep mining and tunneling have significant effects on the stability...
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Article
Estimation of urinary cadmium benchmark dose thresholds for preschool children in a cadmium-polluted area based on Bayesian model averaging
Urinary cadmium (U-Cd) values are indicators for determining chronic cadmium toxicity, and previous studies have calculated U-Cd indicators using renal injury biomarkers. However, most of these studies have be...
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Article
Open AccessProgress of single-cell RNA sequencing combined with spatial transcriptomics in tumour microenvironment and treatment of pancreatic cancer
In recent years, single-cell analyses have revealed the heterogeneity of the tumour microenvironment (TME) at the genomic, transcriptomic, and proteomic levels, further improving our understanding of the mecha...
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Article
Open AccessCompendium of 5810 genomes of sheep and goat gut microbiomes provides new insights into the glycan and mucin utilization
Ruminant gut microbiota are critical in ecological adaptation, evolution, and nutrition utilization because it regulates energy metabolism, promotes nutrient absorption, and improves immune function. To study ...
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Article
Open AccessGenome-wide analysis reveals genomic diversity and signatures of selection in Qinchuan beef cattle
Indigenous Chinese cattle have abundant genetic diversity and a long history of artificial selection, giving local breeds advantages in adaptability, forage tolerance and resistance. The detection of selective...
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Article
Open AccessThe spectrum of factor XI deficiency in Southeast China: four recurrent variants can explain most of the deficiencies
Factor XI (FXI) deficiency is an autosomal hemorrhagic disorder characterized by reduced plasma FXI levels. Multiple ancestral variants in the F11 gene have been identified in Ashkenazi Jews and other selected Eu...
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Article
Hydrogen production from hydrolysis of NaBH4 solution over Co–Fe–B@g-C3N4/NF thin film catalyst
In this study, the double loaded Co–Fe–B@g-C3N4/NF (NF: Ni foam) thin film catalysts were prepared for the first time via chemical deposition method at room temperature. By optimizing the reducing agent concentra...
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Article
Transcriptomic responses of cumulus granulosa cells to SARS-CoV-2 infection during controlled ovarian stimulation
Cumulus granulosa cells (CGCs) play a crucial role in follicular development, but so far, no research has explored the impact of SARS-CoV-2 infection on ovarian function from the perspective of CGCs. In the pr...
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Article
An IMOA DV-Hop localization algorithm in WSN based on hop count and hop distance correction
Wireless sensor networks (WSNs) have been widely used in environmental monitoring due to their low cost advantages. In WSNs monitoring, the location information is significant, because data collected by sensor...
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Article
Open AccessMonitoring warning criterion of acoustic emission active waveguide system based on loess deformation and failure
The construction of acoustic emission criterion system is crucial for monitoring and providing early warning of geological hazards. In the current soil acoustic emission monitoring methods, the signal generate...
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Article
Highly sensitive acetone gas sensor based on gold nanoparticles modified W18O49 porous polymeric spheres
Nanogold-modified W18O49 porous polymer spheres were fabricated using a two-step solvothermal method. The material was characterized in various ways by XRD and SEM. The results show that the material is highly cr...
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Article
Open AccessBiological response to Przewalski’s horse reintroduction in native desert grasslands: a case study on the spatial analysis of ticks
Reintroduction represents an effective strategy for the conservation of endangered wildlife, yet it might inadvertently impact the native ecosystems. This investigation assesses the impact of reintroducing end...
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Article
Open AccessMonocytes release cystatin F dimer to associate with Aβ and aggravate amyloid pathology and cognitive deficits in Alzheimer’s disease
Understanding the molecular mechanisms of Alzheimer’s disease (AD) has important clinical implications for guiding therapy. Impaired amyloid beta (Aβ) clearance is critical in the pathogenesis of sporadic AD, ...
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Article
Treadmill exercise training inhibits morphine CPP by reversing morphine effects on GABA neurotransmission in D2-MSNs of the accumbens-pallidal pathway in male mice
Relapse is a major challenge in the treatment of drug addiction, and exercise has been shown to decrease relapse to drug seeking in animal models. However, the neural circuitry mechanisms by which exercise inh...
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Article
The Continuous Thrust Long-Orbit Satellite Pursuit-Evasion Game Control Using Feedback Genetic Shooting Method
Considering the continuous thrust condition of satellites, the long-orbit satellite pursuit-evasion game emerges as a highly intricate challenge. To address this issue, this study initially adopts the Cartesia...
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Article
Identification and Expression Analysis of Soybean (Glycine max L.) Dynamin Genes Reveal Their Involvements in Plant Development and Stress Response
Dynamin and dynamin-related proteins (DRPs) are large GTPases that are vital for cytokinesis, endocytosis and multiple biological processes. However, knowledge of the DRP gene family in soybean (Glycine max L.), ...
