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  1. Article

    Open Access

    A pan-KRAS degrader for the treatment of KRAS-mutant cancers

    KRAS mutations are highly prevalent in a wide range of lethal cancers, and these mutant forms of KRAS play a crucial role in driving cancer progression and conferring resistance to treatment. While there have bee...

    Jie Yang, Qiao-Li Wang, Guan-Nan Wang, Jia-Cong Ye, Zi-Qian Li… in Cell Discovery (2024)

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    Article

    Histone deacetylase inhibitors deplete myeloid-derived suppressor cells induced by 4T1 mammary tumors in vivo and in vitro

    Myeloid-derived suppressor cells (MDSC) have been identified as a population of immature myeloid cells that suppress anti-tumor immunity. MDSC are increased in tumor-bearing hosts; thus, depletion of MDSC may ...

    Hai-Fang Wang, Fen Ning, Zong-Cai Liu, Long Wu… in Cancer Immunology, Immunotherapy (2017)