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Open AccessFor whom the bell tolls – do we overestimate wall enhancement of intracranial aneurysms?
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Open AccessAssessment of associations between neutrophil extracellular trap biomarkers in blood and thrombi in acute ischemic stroke patients
Inflammation including immunothrombosis by neutrophil extracellular traps (NETs) has important implications in acute ischemic stroke and can affect reperfusion status, susceptibility to stroke associated infec...
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Open AccessAuthor Correction: Warmth and competence perceptions of key protagonists are associated with containment measures during the COVID-19 pandemic: Evidence from 35 countries
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Open AccessWarmth and competence perceptions of key protagonists are associated with containment measures during the COVID-19 pandemic: Evidence from 35 countries
It is crucial to understand why people comply with measures to contain viruses and their effects during pandemics. We provide evidence from 35 countries (Ntotal = 12,553) from 6 continents during the COVID-19 pan...
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Open AccessPhenol-soluble modulin α and β display divergent roles in mice with staphylococcal septic arthritis
Phenol-soluble modulin α (PSMα) is identified as potent virulence factors in Staphylococcus aureus (S. aureus) infections. Very little is known about the role of PSMβ which belongs to the same toxin family. Here ...
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Open AccessThe potential role of diffusion weighted imaging in the diagnosis of early carotid and vertebral artery dissection
To investigate the role of the diffusion weighted imaging (DWI) in the acute dissection of internal carotid artery (ICA) and vertebral artery (VA) and assessing the length of intramural hematoma (IMH), caused ...
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Open AccessStaphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing
Despite being a major bacterial factor in alerting the human immune system, the role of Staphylococcus aureus (S. aureus) lipoproteins (Lpp) in skin infections remains largely unknown. Here, we demonstrated that ...
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Open AccessNew insights in the coordinated amidase and glucosaminidase activity of the major autolysin (Atl) in Staphylococcus aureus
After bacterial cell division, the daughter cells are still covalently interlinked by the peptidoglycan network which is resolved by specific hydrolases (autolysins) to release the daughter cells. In staphyloc...
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Journal Club
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Euclidean distances of laryngopharyngeal structures obtained from CT data for preclinical development of laryngoscopic devices
This study aims to determine Euclidean distances between landmark structures in the larynx and pharynx to optimize endoscope shaft designs with regard to gentle and patient-oriented handling.
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Open AccessTrace amines produced by skin bacteria accelerate wound healing in mice
Certain skin bacteria are able to convert aromatic amino acids (AAA) into trace amines (TA) that act as neuromodulators. Since the human skin and sweat contain a comparatively high content of AAA one can expec...
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Open AccessThe role of Staphylococcus aureus lipoproteins in hematogenous septic arthritis
Permanent joint dysfunction is a devastating complication in patients with septic arthritis. Staphylococcus aureus (S. aureus) lipoproteins (Lpp), the predominant ligands for TLR2, are known to be arthritogenic a...
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Open AccessMpsAB is important for Staphylococcus aureus virulence and growth at atmospheric CO2 levels
The mechanisms behind carbon dioxide (CO2) dependency in non-autotrophic bacterial isolates are unclear. Here we show that the Staphylococcus aureus mpsAB operon, known to play a role in membrane potential genera...
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Open AccessLugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors
Recently our groups discovered lugdunin, a new cyclic peptide antibiotic that inhibits Staphylococcus aureus epithelial colonization in humans and rodents. In this work, we analyzed its immuno-modulatory and anti...
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Open AccessStaphylococcus aureus induces DNA damage in host cell
Staphylococcus aureus causes serious medical problems in human and animals. Here we show that S. aureus can compromise host genomic integrity as indicated by bacteria-induced histone H2AX phosphorylation, a marke...
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Open AccessLantibiotic production is a burden for the producing staphylococci
Lantibiotics are antimicrobial peptides that contain non-proteinogenic amino acids lanthionine and 3-methyllanthionine and are produced by Gram-positive bacteria. Here we addressed the pros and cons of lantibi...
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Open AccessLipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses
Lipoproteins (Lpp) of Gram-positive bacteria are major players in alerting our immune system. Here, we show that the TLR2 response induced by commensal species Staphylococcus aureus and Staphylococcus epidermidis
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Open AccessStaphylococcus carnosus: from starter culture to protein engineering platform
Since the 1950s, Staphylococcus carnosus is used as a starter culture for sausage fermentation where it contributes to food safety, flavor, and a controlled fermentation process. The long experience with S. carno...
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Wie bakterielle Moleküle unser Immunsystem manipulieren
Lipoproteins (Lpp) of Gram-positive bacteria play a crucial role in immune modulation. The degree of lipid acylation determines whether the TLR2/TLR1 or the TLR2/TLR6 signalling pathway is induced in the infec...
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Does severity of cerebral MRI lesions in congenital CMV infection correlates with the outcome of cochlear implantation?
The objective is to investigate whether there is a correlation between the severity of typical brain lesions in congenital cytomegalovirus (cCMV) infection and cochlear implant (CI) outcome. The design of the ...
