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Article
Open AccessToll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants
Sepsis caused by Gram-positive bacterial pathogens is a major fatal disease but its molecular basis remains elusive. Toll-like receptor 2 (TLR2) has been implicated in the orchestration of inflammation and sep...
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Article
Excretion of cytoplasmic proteins in Staphylococcus is most likely not due to cell lysis
The excretion of cytoplasmic proteins (ECP) is a long-known phenomenon in bacteria and eukaryotes. So far, it was not possible to associate either a signal peptide-dependent or a signal peptide-independent pat...
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Article
Surgical treatment of distal anterior cerebral artery aneurysms aided by electromagnetic navigation CT angiography
The surgical treatment of distal anterior cerebral artery (DACA) aneurysms still presents a challenge for neurosurgeons because of their small size and their location in the depth of the narrow frontal interhe...
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Article
Inhibition of staphylococcal biofilm-related gene transcription by rhodomyrtone, a new antibacterial agent
Biofilms are one of the most important staphylococcal virulence factors, which are often associated with antibiotic resistance in the organisms. Our previous studies have demonstrated that rhodomyrtone from Rhodo...
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Article
Quantitative MRI shows cerebral microstructural damage in hemolytic–uremic syndrome patients with severe neurological symptoms but no changes in conventional MRI
Severe neurological symptoms in Shiga toxin-producing Escherichia coli infection associated hemolytic–uremic syndrome (STEC–HUS) are often accompanied by none or only mild alterations of cerebral magnetic resonan...
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Article
Open AccessRole of N-terminal protein formylation in central metabolic processes in Staphylococcus aureus
Bacterial protein biosynthesis usually depends on a formylated methionyl start tRNA but Staphylococcus aureus is viable in the absence of Fmt, the tRNAMet formyl transferase. fmt mutants exhibit reduced growth ra...
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Chapter
Staphylococcal Virulence Factors
The adherence of staphylococci to the unmodified or host factor-coated surface of a medical device is the first critical event in the establishment of a device-associated infection with these serious pathogens. S...
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Chapter
What Distinguishes Highly Pathogenic Staphylococci from Medium- and Non-pathogenic?
Members of the genus Staphylococcus are widespread as commensals of humans and animals where they colonize the skin or mucous membranes. While this coexistence remains mostly untroubled, especially for the health...
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Article
Stimulation of platelet apoptosis by peptidoglycan from Staphylococcus aureus 113
Peptidoglycan (PGN), a component of bacterial cell wall and belonging to “Microbe-Associated Molecular Patterns” (MAMP) triggers host reactions contributing to the pathophysiology of infectious disease. Host c...
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Article
Zinc induced apoptotic death of mouse dendritic cells
Zinc ions (Zn2+) are food components with favourable effects in infectious disease. Zn2+ is taken up into dendritic cells (DCs), key players in the regulation of innate and adaptive immunity. In other cell types,...
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Article
Artifacts caused by cochlear implants with non-removable magnets in 3T MRI: phantom and cadaveric studies
The aim of this study was to evaluate artifacts produced by cochlear implants (CI) during 3.0 Tesla (T) magnetic resonance imaging of the brain using different sequences on phantom and cadaveric specimens. A p...
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Article
Zervikaler Abszess nach lumbaler epiduraler Schmerztherapie
Bericht über eine 49-jährige adipöse Diabetikerin, die wegen langjähriger lumbaler Rückenschmerzen nach zahlreichen, letztendlich erfolglosen Behandlungen unterschiedlichster Art mit computertomographiegestütz...
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Article
Open AccessTranscriptomic and metabolic responses of Staphylococcus aureus exposed to supra-physiological temperatures
Previous evaluation by different molecular and physiological assays of Staphylococcus aureus (S. aureus) responses to heat shock exposure yielded a still fragmentary view of the mechanisms determining bacterial s...
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Article
HIV-associated cerebral lymphocyte infiltration mimicking vestibular schwannoma
The association of unilateral, rapidly progressive hearing loss, tinnitus and vestibular dysfunction in combination with a contrast-enhancing mass within the internal auditory canal on MRI is suggestive of a v...
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Article
Table for Optimization and Monitoring of Cerebral Aneurysm Therapy (TOMCAT)
Several unsolved problems in the treatment of cerebral aneurysms remain that could be addressed in a large multicenter registry. The Table for Optimization and Monitoring of Cerebral Aneurysm Therapy (TOMCAT) ...
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Article
Open AccessThe GraRS regulatory system controls Staphylococcus aureus susceptibility to antimicrobial host defenses
Modification of teichoic acids with D-alanine by the products of the dlt operon protects Gram-positive bacteria against major antimicrobial host defense molecules such as defensins, cathelicidins, myeloperoxidase...
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Article
Extra- and intracranial dumbbell-shaped hemangiopericytoma
Hemangiopericytomas are malignant tumors arising from pericytic cells and account for less than 1% of all vascular neoplasms. We report a rare case of an extra- and intracranial dumbbell-shaped hemangiopericyt...
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Article
Endovascular Treatment of Cerebral Aneurysms Using the Leo Stent: Long-Term Follow-Up and Expansion of Indications
The authors share their extended experience using the Leo stent. Building on their earlier work, they present more cases, a longer follow-up period, and expansion of indications for use of the stent.
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Article
Suicidal erythrocyte death in sepsis
Sequelae of sepsis include anemia which presumably results from accelerated clearance of erythrocytes from circulating blood. The underlying mechanisms, however, remained hitherto elusive. Most recent studies ...
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Article
Erblindung nach präoperativer Partikelembolisation eines Meningeoms
Bericht über eine präoperative Embolisation eines parietalen Falxmeningeoms mit 50-µ-Partikeln. Es kam zu einem Visusverlust des rechten Auges. Ursache war eine nicht erkannte Anastomose zwischen der A. mening...
