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Article
Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus
Antagonistic bacterial interactions often rely on antimicrobial bacteriocins, which attack only a narrow range of target bacteria. However, antimicrobials with broader activity may be advantageous. Here we ide...
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Article
Open AccessGenomic Analysis of Bacteriocin-Producing Staphylococci: High Prevalence of Lanthipeptides and the Micrococcin P1 Biosynthetic Gene Clusters
Bacteriocins are antimicrobial peptides produced by bacteria. This study aimed to in silico analyze the presence of bacteriocin gene clusters (BGCs) among the genomes of 22 commensal Staphylococcus isolates from ...
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Article
The microbiome-sha** roles of bacteriocins
The microbiomes on human body surfaces affect health in multiple ways. They include not only commensal or mutualistic bacteria but also potentially pathogenic bacteria, which can enter sterile tissues to cause...
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Article
Staphylococcus epidermidis clones express Staphylococcus aureus-type wall teichoic acid to shift from a commensal to pathogen lifestyle
Most clonal lineages of Staphylococcus epidermidis are commensals present on human skin and in the nose. However, some globally spreading healthcare-associated and methicillin-resistant S. epidermidis (HA-MRSE) c...
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Article
Open AccessLugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors
Recently our groups discovered lugdunin, a new cyclic peptide antibiotic that inhibits Staphylococcus aureus epithelial colonization in humans and rodents. In this work, we analyzed its immuno-modulatory and anti...
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Article
Open AccessLantibiotic production is a burden for the producing staphylococci
Lantibiotics are antimicrobial peptides that contain non-proteinogenic amino acids lanthionine and 3-methyllanthionine and are produced by Gram-positive bacteria. Here we addressed the pros and cons of lantibi...
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Article
The commensal lifestyle of Staphylococcus aureus and its interactions with the nasal microbiota
Many major bacterial pathogens can be found in the human microbiota and can infect sterile tissues if the host is immunocompromised. Exploring the ecology of s...
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Article
Correction: Corrigendum: Human commensals producing a novel antibiotic impair pathogen colonization
Nature 535, 511–516 (2016); doi:10.1038/nature18634 In the interests of transparency, in this Article we wish to amend the competing financial interests statement to read: “Tuebingen University has filed a pro...
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Article
Human commensals producing a novel antibiotic impair pathogen colonization
The nasal commensal bacterium Staphylococcus lugdunensis produces a novel cyclic peptide antibiotic, lugdunin, that inhibits colonization by S. aureus in animal models and is associated with a significantly re...
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Article
Open AccessAn essential role for the baseplate protein Gp45 in phage adsorption to Staphylococcus aureus
Despite the importance of phages in driving horizontal gene transfer (HGT) among pathogenic bacteria, the underlying molecular mechanisms mediating phage adsorption to S. aureus are still unclear. Phage ϕ11 is a ...
