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Article
Open AccessMpsAB is important for Staphylococcus aureus virulence and growth at atmospheric CO2 levels
The mechanisms behind carbon dioxide (CO2) dependency in non-autotrophic bacterial isolates are unclear. Here we show that the Staphylococcus aureus mpsAB operon, known to play a role in membrane potential genera...
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Article
Open AccessMetabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound
Influenza virus (IV) infections cause severe respiratory illnesses that can be complicated by bacterial super-infections. Previously, we identified the cellular Raf-MEK-ERK cascade as a promising antiviral tar...
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Article
Open AccessToll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants
Sepsis caused by Gram-positive bacterial pathogens is a major fatal disease but its molecular basis remains elusive. Toll-like receptor 2 (TLR2) has been implicated in the orchestration of inflammation and sep...
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Article
Open AccessGlobal antibody response to Staphylococcus aureus live-cell vaccination
The pathogen Staphylococcus aureus causes a broad range of severe diseases and is feared for its ability to rapidly develop resistance to antibiotic substances. The increasing number of highly resistant S. aureus
