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Article
Open AccessPhenol-soluble modulin α and β display divergent roles in mice with staphylococcal septic arthritis
Phenol-soluble modulin α (PSMα) is identified as potent virulence factors in Staphylococcus aureus (S. aureus) infections. Very little is known about the role of PSMβ which belongs to the same toxin family. Here ...
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Article
Open AccessStaphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing
Despite being a major bacterial factor in alerting the human immune system, the role of Staphylococcus aureus (S. aureus) lipoproteins (Lpp) in skin infections remains largely unknown. Here, we demonstrated that ...
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Article
Open AccessThe role of Staphylococcus aureus lipoproteins in hematogenous septic arthritis
Permanent joint dysfunction is a devastating complication in patients with septic arthritis. Staphylococcus aureus (S. aureus) lipoproteins (Lpp), the predominant ligands for TLR2, are known to be arthritogenic a...
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Article
Open AccessModel consent clauses for rare disease research
Rare Disease research has seen tremendous advancements over the last decades, with the development of new technologies, various global collaborative efforts and improved data sharing. To maximize the impact of...
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Article
Open AccessStaphylococcus aureus induces DNA damage in host cell
Staphylococcus aureus causes serious medical problems in human and animals. Here we show that S. aureus can compromise host genomic integrity as indicated by bacteria-induced histone H2AX phosphorylation, a marke...
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Article
Open AccessDiagnosis of rare diseases under focus: impacts for Canadian patients
This paper presents an in-depth qualitative analysis of the impact of diagnosis on the lives of rare disease (RD) patients. While diagnosis may be described as a watershed step for RD patients, no extensive ac...
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Article
Open AccessLipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses
Lipoproteins (Lpp) of Gram-positive bacteria are major players in alerting our immune system. Here, we show that the TLR2 response induced by commensal species Staphylococcus aureus and Staphylococcus epidermidis
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Article
Open AccessStaphylococcus carnosus: from starter culture to protein engineering platform
Since the 1950s, Staphylococcus carnosus is used as a starter culture for sausage fermentation where it contributes to food safety, flavor, and a controlled fermentation process. The long experience with S. carno...
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Article
Wie bakterielle Moleküle unser Immunsystem manipulieren
Lipoproteins (Lpp) of Gram-positive bacteria play a crucial role in immune modulation. The degree of lipid acylation determines whether the TLR2/TLR1 or the TLR2/TLR6 signalling pathway is induced in the infec...
