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Article
Open AccessLanreotide Depot to Treat Gastroenteropancreatic Neuroendocrine Tumors in a US Community Oncology Setting: A Prospective, Observational Study
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) can result in symptoms such as diarrhea, flushing, abdominal pain, and fatigue and are often associated with a significant disease burden and poor progno...
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Article
Open AccessA qualitative study to understand the experience of somatostatin analog treatments from the perspective of patients with neuroendocrine tumors
Neuroendocrine tumors (NETs) negatively impact patients’ quality of life. Octreotide long-acting release (LAR) and lanreotide depot are somatostatin analogs (SSAs) approved to treat NETs. The study objective w...
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Article
Open AccessPatients’ satisfaction with long-acting injectable somatostatin analog therapy for neuroendocrine tumors
Long-acting somatostatin analogs (LA SSAs) are approved and recommended for the treatment of patients with advanced neuroendocrine tumors (NETs). Given the long duration of therapy and differences in administr...
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Article
Open AccessResponse to correspondence on “Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation”
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Article
Open AccessReproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation
CRISPR-Cas9 gene-editing technology has facilitated the generation of knockout mice, providing an alternative to cumbersome and time-consuming traditional embryonic stem cell-based methods. An earlier study re...
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Article
Open AccessGenome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 ind...
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Article
Open AccessThe circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication
The circadian clock regulates immune responses to microbes and affects pathogen replication, but the underlying molecular mechanisms are not well understood. Here we demonstrate that the circadian components B...
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Article
Open AccessEctopic Cushing’s syndrome secondary to olfactory neuroblastoma
We present the case of a patient with Cushing’s syndrome secondary to ectopic ACTH secretion. A MR of the head showed a left-sided nasal mass extending down from the cribriform plate. The patient underwent end...
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Article
Open AccessA non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response
The glucocorticoid receptor (GR) is essential for the stress response in mammals. We investigated potential non-transcriptional roles of GR in cellular stress response using fission yeast as a model.We surpris...
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Article
Open AccessAbstracts from the 3rd International Severe Asthma Forum (ISAF)
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Open AccessAdditive anti-inflammatory effects of corticosteroids and phosphodiesterase-4 inhibitors in COPD CD8 cells
CD8 lymphocytes play an important role in the pathogenesis of COPD. Corticosteroids and phosphodiesterase 4 (PDE4) inhibitors are anti-inflammatory drugs used for COPD treatment. Little is known of the combine...
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Article
An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action
Host defense to bacterial infection and pulmonary inflammation is regulated by a circadian clock within lung epithelial cells and glucocorticoids.
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Article
Open AccessThe role of the liver X receptor in chronic obstructive pulmonary disease
There is a need for novel anti-inflammatory therapies to treat COPD. The liver X receptor (LXR) is a nuclear hormone receptor with anti-inflammatory properties.
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Article
Open AccessT lymphocyte insensitivity to corticosteroids in chronic obstructive pulmonary disease
There are increased numbers of activated lymphocytes in the lungs of chronic obstructive pulmonary disease (COPD) patients. The clinical benefits of corticosteroids in COPD patients are limited. Our hypothesis...
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Article
Case series: The McGrath® videolaryngoscope — an initial clinical evaluation
To document tracheal intubation success rates and airway instrumentation times using the newly designed McGrath® videolaryngoscope.
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A Robust Approach to High-Speed Navigation for Unrehearsed Desert Terrain
This article presents a robust approach to navigating at high-speed across desert terrain. A central theme of this approach is the combination of simple ideas and components to build a capable and robust syste...
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Article
Effects of partial throughfall exclusion on the phenology of Coussarea racemosa (Rubiaceae) in an east-central Amazon rainforest
Severe droughts may alter the reproductive phenology of tropical tree species, but our understanding of these effects has been hampered by confounded variation in drought, light and other factors during natura...
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Article
Open AccessHypothalamic-pituitary-adrenal stress axis function and the relationship with chronic widespread pain and its antecedents
In clinic studies, altered hypothalamic-pituitary-adrenal (HPA) axis function has been associated with fibromyalgia, a syndrome characterised by chronic widespread body pain. These results may be explained by ...
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Chapter
ACTH Precursors in Different Pathological Conditions
ACTH is synthesised as part of a 31kD, pro-hormone, proopiomelano — cortin (POMC), and the processing of POMC is tightly regulated in a tissue specific manner. The POMC processing pathway (seeFigure 1) has been b...
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Article
Organotypic rat brain culture as in vivo-like model system
The goal of the current research was to define an in vitro system that can replace in vivo experimentation but reflects as far as possible aspects of the intact situation of the develo** nervous system of ma...
