18 Result(s)

Article

Exploring the burden, prevalence and associated factors of chronic musculoskeletal pain in migrants from North Africa and Middle East living in Europe: a sco** review

Immigrants are exposed to numerous risk factors that may contribute to the development of chronic musculoskeletal pain. Recent political and environmental crises in North Africa and the Middle East have led to...

Maria-Nefeli Tsetseri, David J. Keene, Alan J. Silman… in BMC Public Health (2024)

Article

The role of national registries in improving patient safety for hip and knee replacements

The serious adverse events associated with metal on metal hip replacements have highlighted the importance of improving methods for monitoring surgical implants.

Anne Lübbeke, Alan J. Silman, Daniel Prieto-Alhambra… in BMC Musculoskeletal Disorders (2017)

Article

Influence of Inflammatory Polyarthritis on Quantitative Heel Ultrasound Measurements

There are few data concerning the impact of inflammatory polyarthritis (IP) on quantitative heel ultrasound (QUS) measurements. The aims of this analysis were i) to determine the influence of IP on QUS measure...

Stephen R Pye, Tarnya Marshall, Karl Gaffney, Robert Luben… in BMC Musculoskeletal Disorders (2012)

Article

Influence of Polymorphisms in the RANKL/RANK/OPG Signaling Pathway on Volumetric Bone Mineral Density and Bone Geometry at the Forearm in Men

We sought to determine the influence of single-nucleotide polymorphisms (SNPs) in RANKL, RANK, and OPG on volumetric bone mineral density (vBMD) and bone geometry at the radius in men. Pairwise tag SNPs (r ...

Delnaz Roshandel, Kate L. Holliday, Stephen R. Pye… in Calcified Tissue International (2011)

Article

A validation of the first genome-wide association study of calcaneus ultrasound parameters in the European Male Ageing Study

A number of single nucleotide polymorphisms (SNPs) have been associated with broadband ultrasound attenuation (BUA) and speed of sound (SOS) as measured by quantitative ultrasound (QUS) at the calcaneus in the...

Delnaz Roshandel, Wendy Thomson, Stephen R Pye, Steven Boonen… in BMC Medical Genetics (2011)

Article

Influence of arthritis and non-arthritis related factors on areal bone mineral density (BMD_a) in women with longstanding inflammatory polyarthritis: a primary care based inception cohort

The aim of this analysis was to determine the relative influence of disease and non-disease factors on areal bone mineral density (BMD_a) in a primary care based cohort of women with inflammatory polyarthritis.

Stephen R Pye, Tarnya Marshall, Karl Gaffney… in BMC Musculoskeletal Disorders (2010)

Article

Why are women predisposed to autoimmune rheumatic diseases?

The majority of autoimmune diseases predominate in females. In searching for an explanation for this female excess, most attention has focused on hormonal changes - both exogenous changes (for example, oral co...

Jacqueline E Oliver, Alan J Silman in Arthritis Research & Therapy (2009)

Article

What epidemiology has told us about risk factors and aetiopathogenesis in rheumatic diseases

This article will review how epidemiological studies have advanced our knowledge of both genetic and environmental risk factors for rheumatic diseases over the past decade. The major rheumatic diseases, includ...

Jacqueline E Oliver, Alan J Silman in Arthritis Research & Therapy (2009)

Article

Available therapeutic options following failure of a first anti-TNF agent

Alan J Silman in Nature Reviews Rheumatology (2009)

Article

Aspects of early arthritis. What determines the evolution of early undifferentiated arthritis and rheumatoid arthritis? An update from the Norfolk Arthritis Register

Over 3500 patients with recent onset inflammatory polyarthritis (IP) have been recruited by the Norfolk Arthritis Register (NOAR) since 1990. Longitudinal data from this cohort have been used to examine the pr...

Deborah PM Symmons, Alan J Silman in Arthritis Research & Therapy (2006)

Article

Clinical trials in rheumatology: an uncertain future?

Alan J Silman in Nature Clinical Practice Rheumatology (2006)

Article

In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype

The aim of this study was to investigate HLA class II associations in polymyositis (PM) and dermatomyositis (DM), and to determine how these associations influence clinical and serological differences. DNA sam...

Hector Chinoy, Fiona Salway, Noreen Fertig, Neil Shephard… in Arthritis Research & Therapy (2005)

Article

Hypothalamic-pituitary-adrenal stress axis function and the relationship with chronic widespread pain and its antecedents

In clinic studies, altered hypothalamic-pituitary-adrenal (HPA) axis function has been associated with fibromyalgia, a syndrome characterised by chronic widespread body pain. These results may be explained by ...

John McBeth, Yee H Chiu, Alan J Silman, David Ray… in Arthritis Research & Therapy (2005)

Article

Psychological stress and fibromyalgia: a review of the evidence suggesting a neuroendocrine link

The present review attempts to reconcile the dichotomy that exists in the literature in relation to fibromyalgia, in that it is considered either a somatic response to psychological stress or a distinct organi...

Anindya Gupta, Alan J Silman in Arthritis Res Ther (2004)

Article

Epidemiology and genetics of rheumatoid arthritis

The prevalence of rheumatoid arthritis (RA) is relatively constant in many populations, at 0.5–1.0%. However, a high prevalence of RA has been reported in the Pima Indians (5.3%) and in the Chippewa Indians (6...

Alan J Silman, Jacqueline E Pearson in Arthritis Research & Therapy (2002)