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Article
Open AccessVenous thromboembolism chemical prophylaxis after endoscopic trans-sphenoidal pituitary surgery
There is no compelling outcome data or clear guidance surrounding postoperative venous thromboembolism (VTE) prophylaxis using low molecular weight heparin (chemoprophylaxis) in patients undergoing pituitary s...
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Article
Long-term oncological outcomes after haemorrhagic apoplexy in pituitary adenoma managed operatively and non-operatively
Depending on severity of presentation, pituitary apoplexy can be managed with acute surgery or non-operatively. We aim to assess long-term tumour control, visual and endocrinological outcomes following pituita...
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Article
Endoscopic transsphenoidal surgery for biochemically and clinically non-functioning adenohypophyseal tumours in the elderly: experience from a single UK centre
To assess and compare outcome of surgical management of non-functioning pituitary adenohypophyseal tumours in patients under 65-years, and 65-years and older at tertiary neurosurgical referral centre.
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Article
Open AccessPre- and postoperative need for pituitary hormone replacement in non-adenomatous sellar and parasellar lesions: importance of the sellar encroachment score
Pre-/postoperative pituitary endocrine deficiencies in patients with sellar/parasellar non-adenomatous lesions are poorly described and studies have not considered the effect of sellar invasion on endocrine ou...
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Article
Open AccessEctopic Cushing’s syndrome secondary to olfactory neuroblastoma
We present the case of a patient with Cushing’s syndrome secondary to ectopic ACTH secretion. A MR of the head showed a left-sided nasal mass extending down from the cribriform plate. The patient underwent end...
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Article
Open AccessThe prevalence of growth hormone deficiency in survivors of subarachnoid haemorrhage: results from a large single centre study
The variation in reported prevalence of growth hormone deficiency (GHD) post subarachnoid haemorrhage (SAH) is mainly due to methodological heterogeneity. We report on the prevalence of GHD in a large cohort o...
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Article
Open AccessSphenoid sinus mucosal thickening in the acute phase of pituitary apoplexy
In pituitary apoplexy (PA), there are preliminary reports on the appearance of sphenoid sinus mucosal thickening (SSMT). SSMT is otherwise uncommon with an incidence of up to 7% in asymptomatic individuals. Th...
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Article
Lymphocytic hypophysitis: modern day management with limited role for surgery
We set out to describe the modern day management of Lymphocytic hypophysitis (LH) with respect to its diagnosis, treatment and long-term endocrine and visual outcomes. We deliberately included patients with a ...
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Article
Low-grade CSF leaks in endoscopic trans-sphenoidal pituitary surgery: efficacy of a simple and fully synthetic repair with a hydrogel sealant
Intra-operative CSF leak during endoscopic trans-sphenoidal surgery is not uncommon. Surgical repair with a variety of autologous grafts, rigid buttresses and CSF diversion techniques that add time and complex...
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Article
Transient asystole during endoscopic transsphenoidal surgery for Acromegaly: an example of trigeminocardiac reflex
Cardiac arrhythmias are rare during transsphenoidal surgery and is often secondary to stimulation of the trigeminal nerve endings that supply the nasal passages and cavernous sinus walls. Authors report a pati...
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Article
Beta human chorionic gonadotropin (β-hCG) expression in pituitary adenomas: relationship to endocrine function and tumour recurrence
The β subunit of human chorionic gonadotropin (β-hCG) is a marker of malignancies. Recent studies have also reported its expression in pituitary adenomas, although its significance is unclear. In this retrospe...
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Article
Predictors of outcome in myxoedema coma
Myxoedema coma is a rare and life-threatening illness the outcome of which has not been robustly studied in large numbers, partly due to its low incidence. Dutta and colleagues have explored outcome predictors...
