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  1. Article

    Proton Magnetic Resonance Spectroscopy of the Brain during Acute Hypoxia-Ischemia and Delayed Cerebral Energy Failure in the Newborn Piglet

    Studies of the brains of severely birth-asphyxiated infants using proton(1H) magnetic resonance spectroscopy (MRS) have shown changes indicating a rise in cerebral lactate (Lac) and a fall in N- acetylaspartate (...

    Juliet Penrice, Ann Lorek, E B Cady, P N Amess, Marzena Wylezinska… in Pediatric Research (1997)

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  2. Article

    Mild Hypothermia after Severe Transient Hypoxia-Ischemia Reduces the Delayed Rise in Cerebral Lactate in the Newborn Piglet

    This study tested the hypothesis that mild hypothermia after severe transient hypoxia-ischemia reduces the subsequent delayed rise in cerebral lactate peak-area ratios as determined by proton (1H) magnetic resona...

    P N Amess, Juliet Penrice, E B Cady, Ann Lorek, Marzena Wylezinska… in Pediatric Research (1997)

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  3. Article

    The Noninvasive Measurement of Absolute Cerebral Deoxyhemoglobin Concentration and Mean Optical Path Length in the Neonatal Brain by Second Derivative Near Infrared Spectroscopy

    We have used second differential near infrared spectroscopy of water to determine the mean optical path length of the neonatal brain. By obtaining the ratio of the second differential features of deoxyhemoglob...

    C E Cooper, C E Elwell, J H Meek, S J Matcher, J S Wyatt, M Cope… in Pediatric Research (1996)

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  4. Article

    Mild Hypothermia after Severe Transient Hypoxia-Ischemia Ameliorates Delayed Cerebral Energy Failure in the Newborn Piglet

    ABSTRACT: Severely birth-asphyxiated human infants develop delayed (“secondary”) cerebral energy failure, which carries a poor prognosis, during the first few days of life. This study tested the hypothesis tha...

    Marianne Thoresen, Juliet Penrice, Ann Lorek, E B Cady… in Pediatric Research (1995)

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  5. Article

    Delayed (“Secondary”) Cerebral Energy Failure after Acute Hypoxia-Ischemia in the Newborn Piglet: Continuous 48-Hour Studies by Phosphorus Magnetic Resonance Spectroscopy

    ABSTRACT: Phosphorus (31P) spectra from the brains of severely birth-asphyxiated human infants are commonly normal on the first day of life. Later, cerebral energy failure develops, which carries a serious progno...

    Ann Lorek, Y Takei, E B Cady, J S Wyatt, Juliet Penrice, A D Edwards… in Pediatric Research (1994)

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