19 Result(s)

Article

Twenty-Four Hours of Mild Hypothermia in Unsedated Newborn Pigs Starting after a Severe Global Hypoxic-Ischemic Insult Is Not Neuroprotective

Three to 12 h of mild hypothermia (HT) starting after hypoxia-ischemia is neuroprotective in piglets that are anesthetized during HT. Newborn infants suffering from neonatal encephalopathy often ventilate spon...

Marianne Thoresen, Saulius Satas, Else Marit Løberg, Andrew Whitelaw… in Pediatric Research (2001)

Article

Magnesium Sulfate Treatment after Transient Hypoxia-Ischemia in the Newborn Piglet Does Not Protect against Cerebral Damage

Transient perinatal hypoxia-ischemia (HI) can lead to delayed cerebral damage beginning 8–24 h after resuscitation. Cerebroprotective therapies applied soon after HI may thus reduce the severity of brain injur...

Kirsty Greenwood, Philip Cox, Huseyin Mehmet, Juliet Penrice… in Pediatric Research (2000)

Article

Organ Pathology after Global Hypoxic Ischemic (HI) Insult Followed by 24 h Mild Hypothermia (HT) in Newborn Pig

Saulius Satas, Helen Porter, Elsa M Loberg, Peter A Steen… in Pediatric Research (1999)

Article

Relation of impaired energy metabolism to apoptosis and necrosis following transient cerebral hypoxia-ischaemia

This study investigated whether both mild and severe hypoxia-ischaemia (HI) caused significant numbers of cells to die by apoptosis in the develo** brain in vivo. Newborn piglets were subjected to transient glo...

Huseyin Mehmet, Xue Yue, Juliet Penrice, Ernest Cady… in Cell Death & Differentiation (1998)

Article

Relation of Energy Metabolism To Apoptosis Following Cerebral Hypoxia-Ischaemia (Hi)

Huseyin Mehmet, Xu Yue, Juliet Penrice, Emest B Cady, John S Wyatt… in Pediatric Research (1997)

Article

Proton Magnetic Resonance Spectroscopy of the Brain during Acute Hypoxia-Ischemia and Delayed Cerebral Energy Failure in the Newborn Piglet

Studies of the brains of severely birth-asphyxiated infants using proton(¹H) magnetic resonance spectroscopy (MRS) have shown changes indicating a rise in cerebral lactate (Lac) and a fall in N- acetylaspartate (...

Juliet Penrice, Ann Lorek, E B Cady, P N Amess, Marzena Wylezinska… in Pediatric Research (1997)

Article

Mild Hypothermia after Severe Transient Hypoxia-Ischemia Reduces the Delayed Rise in Cerebral Lactate in the Newborn Piglet

This study tested the hypothesis that mild hypothermia after severe transient hypoxia-ischemia reduces the subsequent delayed rise in cerebral lactate peak-area ratios as determined by proton (¹H) magnetic resona...

P N Amess, Juliet Penrice, E B Cady, Ann Lorek, Marzena Wylezinska… in Pediatric Research (1997)

Article

Magnesium Sulfate after Transient Hypoxia-Ischemia Fails to Prevent Delayed Cerebral Energy Failure in the Newborn Piglet

Severely birth-asphyxiated human infants develop delayed(“secondary”) cerebral energy failure, which carries a poor prognosis, during the first few days of life. This study tested the hypothesis that i.v. magn...

Juliet Penrice, P N Amess, S Punwani, Marzena Wylezinska… in Pediatric Research (1997)

Article

Proton Magnetic Resonance Spectroscopy of the Brain in Normal Preterm and Term Infants, and Early Changes after Perinatal Hypoxia-Ischemia

The aims of this study were 1) to define normal perinatal maturational changes in proton metabolite peak-area ratios in two regions of the neonatal brain, the thalamic and occipitoparietal regions, and2) to inves...

Juliet Penrice, E B Cady, Ann Lorek, Marzena Wylezinska, P N Amess… in Pediatric Research (1996)

Article

Mild Hypothermia after Severe Transient Hypoxia-Ischemia Ameliorates Delayed Cerebral Energy Failure in the Newborn Piglet

ABSTRACT: Severely birth-asphyxiated human infants develop delayed (“secondary”) cerebral energy failure, which carries a poor prognosis, during the first few days of life. This study tested the hypothesis tha...

Marianne Thoresen, Juliet Penrice, Ann Lorek, E B Cady… in Pediatric Research (1995)

Article

Delayed (“Secondary”) Cerebral Energy Failure after Acute Hypoxia-Ischemia in the Newborn Piglet: Continuous 48-Hour Studies by Phosphorus Magnetic Resonance Spectroscopy

ABSTRACT: Phosphorus (³¹P) spectra from the brains of severely birth-asphyxiated human infants are commonly normal on the first day of life. Later, cerebral energy failure develops, which carries a serious progno...

Ann Lorek, Y Takei, E B Cady, J S Wyatt, Juliet Penrice, A D Edwards… in Pediatric Research (1994)

Article

134 CEREBRAL LACTATE AND N-ACETYLASPARTATE/CHOLINE RATIOS AND DELAYED ENERGY FAILURE FOLLOWING ACUTE HYPOXIA-ISCHAEMIA IN THE NEWBORN PIG

Falling [phosphocreatine(PCr)]/[inorganic phosphate(Pi)] following perinatal asphyxia indicates a bad prognosis, as may increases in lactate(lac)/choline(cho) peak area ratios. The aim of this study was to def...

Ann Lorek, Ernest Cady, Juliet Penrice, John Wyatt, Yukito Takei… in Pediatric Research (1994)

Article

107 MOTOR TESTS OF INTERHEMISPHERIC CONTROL AND COGNITIVE FUNCTION IN VERY PRETERM INFANTS AT EIGHT YEARS

We have previously reported that damage to the posterior corpus callosum might explain some of the subtle cognitive processing deficits found later in many preterm infants. To test this hypothesis we carried o...

Vincent Kirk Bride, Jenny Baudin, Ann Lorek, Judith Meek… in Pediatric Research (1994)

Article

42 HIGH SPIN-SPIN RELAXATION TIMES SEEN BY PROTON MAGNETIC RESONANCE SPECTROSCOPY IN PIGLET BRAINS CORRELATE WITH ATP DEPLETION AFTER ACUTE HYPOXIA-ISCHAEMIA

Using ¹H and ³¹P magnetic resonance spectroscopy (MRS) we aimed to investigate relationships between ¹H spin-spin relaxation times (T₂s) and nucleotide triphosphate (NTP; largely ATP) levels in newborn piglet bra...

Ernest Cady, Ann Lorek, Juliet Penrice, David Edwards, Guy Brown… in Pediatric Research (1994)

Article

220 DO PERIVENTRICULAR FLARES (PVF) PREDICT OUTCOME?

Interpretation and significance of PVF seen with ultrasound (US) in the brains of newborn infants remain controversial. To find out if PVF predict adverse neurodevelopment, follow up data for PVF without periv...

Ann Stewart, John Wyatt, Ann Lorek, Vincent Kirkbride, Judith Meek… in Pediatric Research (1994)

Article

186 LOCALISED H MAGNETIC RESONANCE SPECTROSCOPY OF THE BRAIN IN NORMAL AND PERINATALLY ASPHYXIATED INFANTS

The aims of this study were to define ¹H metabolite peak area ratios in normal infants and to investigate abnormalities after perinatal asphyxia. The normal infants (n=14) were studied at a gestational plus postn...

Juliet Penrice, Ernest Cady, Ann Lorek, Richard Aldridge… in Pediatric Research (1994)