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Article
Open AccessDivergent epigenetic responses to perinatal asphyxia in severe mental disorders
Epigenetic modifications influenced by environmental exposures are molecular sources of phenotypic heterogeneity found in schizophrenia and bipolar disorder and may contribute to shared etiopathogenetic mechan...
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Article
Open AccessAuthor Correction: Cerebellar growth, volume and diffusivity in children cooled for neonatal encephalopathy without cerebral palsy
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Article
Open AccessThe impact of placental genomic risk for schizophrenia and birth asphyxia on brain development
The placenta plays a role in fetal brain development, and pregnancy and birth complications can be signs of placental dysfunction. Birth asphyxia is associated with smaller head size and higher risk of develop...
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Article
Open AccessCerebellar growth, volume and diffusivity in children cooled for neonatal encephalopathy without cerebral palsy
Children cooled for HIE and who did not develop cerebral palsy (CP) still underperform at early school age in motor and cognitive domains and have altered supra-tentorial brain volumes and white matter connect...
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Article
Open AccessCommunication skills in children aged 6–8 years, without cerebral palsy cooled for neonatal hypoxic-ischemic encephalopathy
We assessed communication skills of 48 children without cerebral palsy (CP) treated with therapeutic hypothermia (TH) for neonatal hypoxic-ischemic encephalopathy (HIE) (cases) compared to 42 controls at early...
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Article
Open AccessVariability and sex-dependence of hypothermic neuroprotection in a rat model of neonatal hypoxic–ischaemic brain injury: a single laboratory meta-analysis
Therapeutic hypothermia (HT) is standard care for term infants with hypoxic–ischaemic (HI) encephalopathy. However, the efficacy of HT in preclinical models, such as the Vannucci model of unilateral HI in the ...
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Article
Should therapeutic hypothermia be offered to babies with mild neonatal encephalopathy in the first 6 h after birth?
Infants with moderate to severe neonatal encephalopathy (NE) benefit significantly from therapeutic hypothermia, with reduced risk of death or disability. However, the need for therapeutic hypothermia for infa...
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Article
Therapeutic Hypothermia in Neonatal Hypoxic-Ischemic Encephalopathy
Therapeutic hypothermia reduces death or disability in term and near-term infants with moderate-severe hypoxic-ischemic encephalopathy. Nevertheless, many infants still survive with disability, despite hypothe...
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Article
Rectal temperature in the first five hours after hypoxia–ischemia critically affects neuropathological outcomes in neonatal rats
Hyperthermia after hypoxia–ischemia (HI) in newborn infants is associated with worse neurological outcomes. Loss of thermoregulation may also be associated with greater injury.
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Article
Therapeutic hypothermia translates from ancient history in to practice
Acute postasphyxial encephalopathy around the time of birth remains a major cause of death and disability. The possibility that hypothermia may be able to prevent or lessen asphyxial brain injury is a “dream r...
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Article
Open AccessTreatment temperature and insult severity influence the neuroprotective effects of therapeutic hypothermia
Therapeutic hypothermia (HT) is standard care for moderate and severe neonatal hypoxic-ischaemic encephalopathy (HIE), the leading cause of permanent brain injury in term newborns. However, the optimal tempera...
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Article
Open AccessNeuroprotection after infection-sensitized neonatal hypoxic-ischemic brain injury
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Article
Adding 5 h delayed xenon to delayed hypothermia treatment improves long-term function in neonatal rats surviving to adulthood
We previously reported that combining immediate hypothermia with immediate or 2 h delayed inhalation of an inert gas, xenon, gave additive neuroprotection in rats after a hypoxic–ischemic insult, compared to h...
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Article
Neonatal seizures still lack safe and effective treatment
Seizures after neonatal hypoxia are difficult to treat. A recent antiepileptic safety and dose-finding study examined phenobarbital plus bumetanide, but was stopped owing to apparent futility and increased ris...
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Article
Minimal systemic hypothermia combined with selective head cooling evaluated in a pig model of hypoxia-ischemia
Selective head cooling (SHC) with moderate hypothermia (HT) and whole-body cooling are beneficial following perinatal asphyxia. SHC with systemic normothermia (NT) or minimal HT is under-investigated, could ob...
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Article
Respiratory sinus arrhythmia stabilizes mean arterial blood pressure at high-frequency interval in healthy humans
Arterial blood pressure variations are an independent risk factor for end organ failure. Respiratory sinus arrhythmia (RSA) is a sign of a healthy cardiovascular system. However, whether RSA counteracts arteri...
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Protocol
A Newborn Piglet Survival Model of Post-hemorrhagic Ventricular Dilatation (PHVD)
Intra-ventricular hemorrhage (IVH) and post-hemorrhagic ventricular dilatation (PHVD) are important issues in neonatal care and continue to contribute to significant motor and cognitive morbidity. Several ques...
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Article
Combined effect of hypothermia and caspase-2 gene deficiency on neonatal hypoxic–ischemic brain injury
Hypoxia–ischemia (HI) injury in term infants develops with a delay during the recovery phase, opening up a therapeutic window after the insult. Hypothermia is currently an established neuroprotective treatment...
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Article
Resuscitation with 100% oxygen increases injury and counteracts the neuroprotective effect of therapeutic hypothermia in the neonatal rat
Mild therapeutic hypothermia (HT) reduces brain injury in survivors after perinatal asphyxia. Recent guidelines suggest that resuscitation of term infants should be started with air, but supplemental oxygen is...
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Article
Xenon offers stable haemodynamics independent of induced hypothermia after hypoxia–ischaemia in newborn pigs
To assess the effect of 18 hour (h) 50% xenon (Xe) inhalation at normothermia (NT, 38.5°C) or hypothermia (HT, 33.5°C) on mean arterial blood pressure (MABP), inotropic support and heart rate (HR) following an...
