57 Result(s)

Article

Mechanisms of brain injury in the newborn

Advances in obstetric and neonatal medical care have led to marked improvements in the chances of survival for extremely preterm and low birth weight babies. This review focuses on the mechanisms of neurologic...

J S Wyatt in Eye (2007)

Article

341 Prediction of Adverse Outcome by Thalamic and Basal Ganglia MRI T2 Relaxometry and Thalamic Proton Mrs in Neonatal Encephalopathy

Background: Robust quantitative methods are needed to assess the severity of cerebral injury following perinatal hypoxia-ischaemia and to ascertain the efficacy of neuroprotective therapies.

S Shanmugalingam, J S Thornton, A Bainbridge, F O'Brien, E Cady… in Pediatric Research (2005)

Article

17 Relationship Between Cerebral Oxygen Delivery, Cerebral Metabolic Rate and the Mean Cerebral Oxygen Saturation in Preterm Infants

BACKGROUND Ensuring the adequacy of cerebral oxygen delivery to meet metabolic demand is important in the brain orientated care of newborn infants. Spatially resolved near-infrared spectroscopy (SRS) is an opt...

T Austin, T Leung, F Wong, C E Elwell, J Henty, J H Meek, J S Wyatt in Pediatric Research (2005)

Article

416 Cerebral Alanine Increases During the Evolution of Secondary Energy Failure Following Transient Hypoxia-Ischaemia in Newborn Brain

Background: Alanine (Ala), a nonessential amino acid, is present in normal brain at a concentration of ∼0.5 mmol/kg. During acute hypoxia-ischaemia (HI) Ala increases due to decreased flux of pyruvate through ...

D A West, J S Thornton, M Wylezinska, E De Vita, E B Cady… in Pediatric Research (2005)

Article

85 Initial Experiences of Magnetic Resonance Imaging and Spectroscopy of the Newborn Brain At 4.7 Tesla

Background. The potential benefits of high-field magnetic resonance (MR) include increased signal, contrast, and spectral/spatial resolution, however there are specific safety and cost implications.

E De Vita, A Bainbridge, J Cheong, C Hagmann, P Kinchesh, E Cady… in Pediatric Research (2005)

Article

16 Three Dimensional Optical Imaging of Neonatal Brain Activation

BACKGROUND the ability to assess cerebral function at the cotside is important for our understanding of brain development in the newborn. Existing electrophysiological and optical techniques primarily measure ...

T Austin, A P Gibson, N L Everdell, J C Hebden, M Schweiger… in Pediatric Research (2005)

Article

180 Cerebral Energy Depletion During Hypoxia-Ischaemia, Therapeutic Window, and Regional Severity of Secondary Energy Failure in Newborn Piglets

Background: Following transient hypoxia-ischaemia (HI) a latent phase or therapeutic window exists when intervention, such as hypothermia, may ameliorate the secondary energy failure (SEF), which is associated...

O Iwata, E De Vita, A Bainbridge, S Iwata, D A West, G Raivich… in Pediatric Research (2005)

Article

236 Non-Invasive Cerebral Temperature Map** by Proton Spectroscopic Imaging

Background: Cerebral hypothermia shows promise as a neuroprotective strategy following perinatal hypoxia-ischaemia. A non-invasive technique for the quantification of regional brain temperature is urgently requir...

S Shanmugalingam, J S Thornton, O Iwata, S Iwata, E B Cady… in Pediatric Research (2004)

Article

11 Optical Imaging of The Neonatal Brain

Background: Perinatal brain injury remains an important problem for critically ill newborn infants. Optical methods provide a means of monitoring brain oxygenation safely in an intensive care environment. Informa...

T Austin, J C Hebden, A Gibson, R M Yusof, S R Arridge, J H Meek… in Pediatric Research (2004)

Article

225 Changes In Survival And Neurodevelopmental Outcome in 22 to 25 Week Gestation Infants Over A 20 Year Period

Background: Advances in neonatal care have resulted in the survival of increasing numbers of extremely preterm infants. There have been concerns that the improved survival of infants born at the limit of viabilit...

K J Riley, S Roth, M Sellwood, J S Wyatt in Pediatric Research (2004)

Article

118 Delayed Hypoyhermia is Neuroprotective in Moderate, but not Severe, Perinatal Hypoxic-Ischaemic Brain Injury

Background: Hypothermic neuronal rescue therapy is a potent treatment for the newborn infant with hypoxic-ischaemic (HI) brain injury; the degree of neuroprotection, however, may be dependent on the delay, durati...

O Iwata, E De Vita, F O'Brien, J S Thornton, S Iwata, D Peebles… in Pediatric Research (2004)

Article

10 Mean Cerebral Oxygen Saturation Increases with Gestational Age in Preterm Infants

Background: Ensuring the adequacy of cerebral oxygen delivery to meet metabolic demand is important in the brain orientated intensive care of preterm infants. Spatially resolved near-infrared spectroscopy allows ...

T Austin, J Henty, J H Meek, C E Elwell, J S Wyatt in Pediatric Research (2004)

Article

269 Secondary Energy Failure in a Model of Hypoxic Ischaemic Brain Injury Assessed by Serial Phosphorous Magnetic Resonance Spectroscopy, Water Apparent Diffusion and Electrophysiology: A Pilot Study

Background: The electroencephalogram (EEG) provides a sensitive means of predicting outcome early after perinatal hypoxia-ischaemia (HI). The amplitude integrated EEG (aEEG), a compressed, rectified and filtered ...

D A West, O Iwata, E De Vita, A Bainbridge, S Iwata, J L Cheong… in Pediatric Research (2004)

Article

Visually evoked haemodynamic responses in infants with cerebral pathology

J Meek, M Noone, C E Elwell, J S Wyatt in Pediatric Research (1999)

Article

Changes in the apparent diffusion coefficient of water (ADC) and phosphocreatine to inorganic phosphate ratio (PCr/Pi) in newborn pigs following hypoxia-ischaemia (HI)

M Sellwood, J S Thornton, F E O'Brien, R J Ordidge, K J Brooks… in Pediatric Research (1999)

Article

Cerebral hyperaemia following hypoxic-ischaemic injury injury in the anaesthetised, newborn piglet

M Sellwood, R Springett, J Penrice, P N Amess, L Tyszczuk, D T Delpy… in Pediatric Research (1998)

Article

Age related characteristics of functionally evoked haemodynamic changes in the infant brain

J H Meek, M A Noone, C E Elwell, M A Firbank, J S Wyatt in Pediatric Research (1998)

Article

Proton Magnetic Resonance Spectroscopy of the Brain during Acute Hypoxia-Ischemia and Delayed Cerebral Energy Failure in the Newborn Piglet

Studies of the brains of severely birth-asphyxiated infants using proton(¹H) magnetic resonance spectroscopy (MRS) have shown changes indicating a rise in cerebral lactate (Lac) and a fall in N- acetylaspartate (...

Juliet Penrice, Ann Lorek, E B Cady, P N Amess, Marzena Wylezinska… in Pediatric Research (1997)

Article

Mild Hypothermia after Severe Transient Hypoxia-Ischemia Reduces the Delayed Rise in Cerebral Lactate in the Newborn Piglet

This study tested the hypothesis that mild hypothermia after severe transient hypoxia-ischemia reduces the subsequent delayed rise in cerebral lactate peak-area ratios as determined by proton (¹H) magnetic resona...

P N Amess, Juliet Penrice, E B Cady, Ann Lorek, Marzena Wylezinska… in Pediatric Research (1997)

Article

Magnesium Sulfate after Transient Hypoxia-Ischemia Fails to Prevent Delayed Cerebral Energy Failure in the Newborn Piglet

Severely birth-asphyxiated human infants develop delayed(“secondary”) cerebral energy failure, which carries a poor prognosis, during the first few days of life. This study tested the hypothesis that i.v. magn...

Juliet Penrice, P N Amess, S Punwani, Marzena Wylezinska… in Pediatric Research (1997)