27 Result(s)

Article

Impaired Neurodevelopmental Outcome Associated with Increased White Matter CHO/CR in Preterm Infants

Background: Diffuse white matter (WM) injury is the commonest MR finding in preterm infants. We aimed to describe the metabolic signature of diffuse WM injury and correlate to neurodevelopmental outcome at 1 year...

G S Kendall, D Price, A Bainbridge, S Johnson, C Hagmann, R Gunny… in Pediatric Research (2011)

Article

416 Cerebral Alanine Increases During the Evolution of Secondary Energy Failure Following Transient Hypoxia-Ischaemia in Newborn Brain

Background: Alanine (Ala), a nonessential amino acid, is present in normal brain at a concentration of ∼0.5 mmol/kg. During acute hypoxia-ischaemia (HI) Ala increases due to decreased flux of pyruvate through ...

D A West, J S Thornton, M Wylezinska, E De Vita, E B Cady… in Pediatric Research (2005)

Article

180 Cerebral Energy Depletion During Hypoxia-Ischaemia, Therapeutic Window, and Regional Severity of Secondary Energy Failure in Newborn Piglets

Background: Following transient hypoxia-ischaemia (HI) a latent phase or therapeutic window exists when intervention, such as hypothermia, may ameliorate the secondary energy failure (SEF), which is associated...

O Iwata, E De Vita, A Bainbridge, S Iwata, D A West, G Raivich… in Pediatric Research (2005)

Article

236 Non-Invasive Cerebral Temperature Map** by Proton Spectroscopic Imaging

Background: Cerebral hypothermia shows promise as a neuroprotective strategy following perinatal hypoxia-ischaemia. A non-invasive technique for the quantification of regional brain temperature is urgently requir...

S Shanmugalingam, J S Thornton, O Iwata, S Iwata, E B Cady… in Pediatric Research (2004)

Article

118 Delayed Hypoyhermia is Neuroprotective in Moderate, but not Severe, Perinatal Hypoxic-Ischaemic Brain Injury

Background: Hypothermic neuronal rescue therapy is a potent treatment for the newborn infant with hypoxic-ischaemic (HI) brain injury; the degree of neuroprotection, however, may be dependent on the delay, durati...

O Iwata, E De Vita, F O'Brien, J S Thornton, S Iwata, D Peebles… in Pediatric Research (2004)

Article

269 Secondary Energy Failure in a Model of Hypoxic Ischaemic Brain Injury Assessed by Serial Phosphorous Magnetic Resonance Spectroscopy, Water Apparent Diffusion and Electrophysiology: A Pilot Study

Background: The electroencephalogram (EEG) provides a sensitive means of predicting outcome early after perinatal hypoxia-ischaemia (HI). The amplitude integrated EEG (aEEG), a compressed, rectified and filtered ...

D A West, O Iwata, E De Vita, A Bainbridge, S Iwata, J L Cheong… in Pediatric Research (2004)

Article

Changes in the apparent diffusion coefficient of water (ADC) and phosphocreatine to inorganic phosphate ratio (PCr/Pi) in newborn pigs following hypoxia-ischaemia (HI)

M Sellwood, J S Thornton, F E O'Brien, R J Ordidge, K J Brooks… in Pediatric Research (1999)

Article

Proton Magnetic Resonance Spectroscopy of the Brain during Acute Hypoxia-Ischemia and Delayed Cerebral Energy Failure in the Newborn Piglet

Studies of the brains of severely birth-asphyxiated infants using proton(¹H) magnetic resonance spectroscopy (MRS) have shown changes indicating a rise in cerebral lactate (Lac) and a fall in N- acetylaspartate (...

Juliet Penrice, Ann Lorek, E B Cady, P N Amess, Marzena Wylezinska… in Pediatric Research (1997)

Article

Mild Hypothermia after Severe Transient Hypoxia-Ischemia Reduces the Delayed Rise in Cerebral Lactate in the Newborn Piglet

This study tested the hypothesis that mild hypothermia after severe transient hypoxia-ischemia reduces the subsequent delayed rise in cerebral lactate peak-area ratios as determined by proton (¹H) magnetic resona...

P N Amess, Juliet Penrice, E B Cady, Ann Lorek, Marzena Wylezinska… in Pediatric Research (1997)

Article

Magnesium Sulfate after Transient Hypoxia-Ischemia Fails to Prevent Delayed Cerebral Energy Failure in the Newborn Piglet

Severely birth-asphyxiated human infants develop delayed(“secondary”) cerebral energy failure, which carries a poor prognosis, during the first few days of life. This study tested the hypothesis that i.v. magn...

Juliet Penrice, P N Amess, S Punwani, Marzena Wylezinska… in Pediatric Research (1997)

Article

Proton Magnetic Resonance Spectroscopy of the Brain in Normal Preterm and Term Infants, and Early Changes after Perinatal Hypoxia-Ischemia

The aims of this study were 1) to define normal perinatal maturational changes in proton metabolite peak-area ratios in two regions of the neonatal brain, the thalamic and occipitoparietal regions, and2) to inves...

Juliet Penrice, E B Cady, Ann Lorek, Marzena Wylezinska, P N Amess… in Pediatric Research (1996)

Article

Mild Hypothermia after Severe Transient Hypoxia-Ischemia Ameliorates Delayed Cerebral Energy Failure in the Newborn Piglet

ABSTRACT: Severely birth-asphyxiated human infants develop delayed (“secondary”) cerebral energy failure, which carries a poor prognosis, during the first few days of life. This study tested the hypothesis tha...

Marianne Thoresen, Juliet Penrice, Ann Lorek, E B Cady… in Pediatric Research (1995)

Article

Delayed (“Secondary”) Cerebral Energy Failure after Acute Hypoxia-Ischemia in the Newborn Piglet: Continuous 48-Hour Studies by Phosphorus Magnetic Resonance Spectroscopy

ABSTRACT: Phosphorus (³¹P) spectra from the brains of severely birth-asphyxiated human infants are commonly normal on the first day of life. Later, cerebral energy failure develops, which carries a serious progno...

Ann Lorek, Y Takei, E B Cady, J S Wyatt, Juliet Penrice, A D Edwards… in Pediatric Research (1994)

Article

CEREBRAL HAEMODYNAMICS DURING FAILURE OF OXIDATIVE PHOSPHORYLATION FOLLOWING BIRTH ASPHYXIA

Twelve infants born at 36-42 weeks of gestation who had suffered severe birth asphyxia were studied repeatedly in the first week of life by near infrared spectroscopy (NIRS) and magnetic resonance spectroscopy...

J S Wyatt, A D Edwards, D Azzopardi, C E Richardson, M Cope… in Pediatric Research (1989)

Article

Prognosis of Newborn Infants with Hypoxic-Ischemic Brain Injury Assessed by Phosphorus Magnetic Resonance Spectroscopy

ABSTRACT: To investigate the prognostic significance of abnormalities of oxidative phosphorylation, the brains of 61 newborn infants born at 27-42 wk of gestation and suspected of hypoxic-ischemic brain injury...

D Azzopardi, J S Wyatt, E B Cady, D T Delpy, J Baudin, A L Stewart… in Pediatric Research (1989)

Article

Phosphorus Metabolites and Intracellular pH in the Brains of Normal and Small for Gestational Age Infants Investigated by Magnetic Resonance Spectroscopy

ABSTRACT: The brains of 30 normal preterm and term infants whose birth wt were appropriate for gestational age and 13 who were small for gestational age but healthy were studied by phosphorus magnetic resonanc...

D Azzopardi, J S Wyatt, P A Hamilton, E B Cady, D T Delpy, P L Hope… in Pediatric Research (1989)