27 Result(s)
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Association of childhood trauma exposure and GABRA2 polymorphisms with risk of posttraumatic stress disorder in adults
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Article
Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
Major depressive disorder (MDD) is a common complex trait with enormous public health significance. As part of the Genetic Association Information Network initiative of the US Foundation for the National Insti...
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Open AccessThe genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data
The relationship between major depressive disorder (MDD) and bipolar disorder (BD) remains controversial. Previous research has reported differences and similarities in risk factors for MDD and BD, such as pre...
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Identification of tag haplotypes for 5HTTLPR for different genome-wide SNP platforms
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Open AccessGenome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned
Major depressive disorder (MDD) is a common complex disorder with a partly genetic etiology. We conducted a genome-wide association study of the MDD2000+ sample (2431 cases, 3673 screened controls and >1 M imp...
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Meta-analysis of genome-wide association studies for personality
Personality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in personality is predictive of many outcomes in life, ...
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Open AccessCommon SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion
The personality traits of neuroticism and extraversion are predictive of a number of social and behavioural outcomes and psychiatric disorders. Twin and family studies have reported moderate heritability estim...
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Erratum: Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion
Correction to: Translational Psychiatry (2012) 2, e102; doi:10.1038/tp.2012.27; published online 17 April 2012 Following the online publication of this article, the authors noted that the affiliation for Dr A ...
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Open AccessA genome-wide meta-analysis of association studies of Cloninger's Temperament Scales
Temperament has a strongly heritable component, yet multiple independent genome-wide studies have failed to identify significant genetic associations. We have assembled the largest sample to date of persons wi...
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Open AccessThe genetics of addiction—a translational perspective
Addictions are serious and common psychiatric disorders, and are among the leading contributors to preventable death. This selective review outlines and highlights the need for a multi-method translational app...
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Erratum: The genetics of addiction—a translational perspective
Correction to: Translational Psychiatry (2012) 2, e140; doi:10.1038/tp.2012.54; published online 17 July 2012 As the result of an editing error, two check marks were omitted from Box 1. In the ‘DSM-5’ column, ...
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Open AccessGenome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM
Coffee consumption is a model for addictive behavior. We performed a meta-analysis of genome-wide association studies (GWASs) on coffee intake from 8 Caucasian cohorts (N=18 176) and sought replication of our top...
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Open AccessMulti-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder
Major depressive disorder (MDD) is a common psychiatric illness characterized by low mood and loss of interest in pleasurable activities. Despite years of effort, recent genome-wide association studies (GWAS) ...
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Open AccessMonozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin
Our understanding of major depressive disorder (MDD) has focused on the influence of genetic variation and environmental risk factors. Growing evidence suggests the additional role of epigenetic mechanisms inf...
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A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53
Several studies have identified genes associated with alcohol-use disorders (AUDs), but the variation in each of these genes explains only a small portion of the genetic vulnerability. The goal of the present ...
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Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample
Smoking is a major risk factor for several somatic diseases and is also emerging as a causal factor for neuropsychiatric disorders. Genome-wide association (GWA) and candidate gene studies for smoking behavior...
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Genetic predisposition to schizophrenia associated with increased use of cannabis
Cannabis is the most commonly used illicit drug worldwide. With debate surrounding the legalization and control of use, investigating its health risks has become a pressing area of research. One established as...
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Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW)...
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Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study
Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide...
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Open AccessGenome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium
Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psycholog...
