31 Result(s)

Article

Enfuvirtide: the first therapy to inhibit the entry of HIV-1 into host CD4 lymphocytes

Article

Multiple actions of lysophosphatidylcholine in human Jurkat T cells

To obtain pathophysiological meanings of lysophosphatidylcholine (LPC) through the investigation of the effects of LPC in Jurkat T cells.

Young-** Im, Yun-kyung Lee, Hae-young Chung, Dong-soon Im in Acta Pharmacologica Sinica (2006)

Article

Cytotoxic and apoptotic effects of prenylflavonoid artonin B in human acute lymphoblastic leukemia cells

To investigate the anticancer effects and molecular mechanism of artonin B on the human acute lymphoblastic leukemia CCRF-CEM cells compared with other prenylflavonoid compounds.

Chun-chung Lee, Chun-nan Lin, Guey-mei Jow in Acta Pharmacologica Sinica (2006)

Article

Stimulation of melanogenesis by scoparone in B16 melanoma cells

The effect of coumarin derivatives on melanogenesis was investigated in B16 murine melanoma cells.

Jeong-yeh Yang, Jeung-hyun Koo, Young-gil Song… in Acta Pharmacologica Sinica (2006)

Article

Modulation of inflammation-related genes of polysaccharides fractionated from mycelia of medicinal basidiomycete Antrodia camphorata

To investigate the effect of water soluble-ethanol precipitation fraction (AC-1) and alkaline extraction-isoelectric precipitation fraction (AC-2) from Antrodia camphorata (Polyporaceae, Aphyllophorales) on lipop...

Yen-ying Wu, Chin-chu Chen, Charng-cherng Chyau, Sin-yi Chung… in Acta Pharmacologica Sinica (2007)

Article

Nucleotide receptor signalling and the generation of reactive oxygen species

Elevated levels of extracellular nucleotides are present at sites of inflammation, platelet degranulation and cellular damage or lysis. These extracellular nucleotides can lead to the activation of purinergic ...

Alma N. Guerra, Monica L. Gavala, Hun Sun Chung, Paul J. Bertics in Purinergic Signalling (2007)

Article

β-Sitosterol sensitizes MDA-MB-231 cells to TRAIL-induced apoptosis

To investigate whether subtoxic concentration of β-sitosterol (SITO) combined with TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in TRAIL-resistant MDA-MB-231 breast cancer cells.

Cheol Park, Dong-oh Moon, Chung-ho Ryu, Byung tae Choi… in Acta Pharmacologica Sinica (2008)

Article

Effect of TGF-β1 antisense oligodeoxynucleotide on renal function in chronic renal failure rats

The aim of the present study was to investigate the effectiveness of transforming growth factor (TGF)-β1 antisense oligodeoxynucleotides (ODN) in ameliorating deteriorated kidney function in rats with puromyci...

Law Chung Hiong, Kiew Lik Voon, Nor Azizan Abdullah… in Acta Pharmacologica Sinica (2008)

Article

Effect of sugar positions in ginsenosides and their inhibitory potency on Na⁺/K⁺-ATPase activity

To determine whether ginsenosides with various sugar attachments may act as active components responsible for the cardiac therapeutic effects of ginseng and sanqi (the roots of Panax ginseng and Panax notoginseng

Ronald JY Chen, Tse-yu Chung, Feng-yin Li, Nan-hei Lin… in Acta Pharmacologica Sinica (2009)

Article

Lactational coumestrol exposure increases ovarian apoptosis in adult rats

This study is the first to examine the increased apoptosis in the adult rat ovary after lactational exposure to coumestrol (COU), a potent phytoestrogen. Lactating dams were gavaged at doses of 0.01, 0.1, 1, a...

Hyun-Ju Moon, Ji Hyun Seok, Soon Sun Kim, Gyu Seek Rhee… in Archives of Toxicology (2009)

Article

Increase in sphingolipid catabolic enzyme activity during aging

To understand the contribution of sphingolipid metabolism and its metabolites to development and aging.

Santosh J Sacket, Hae-young Chung, Fumikazu Okajima… in Acta Pharmacologica Sinica (2009)

Article

High dosage of Exendin-4 increased early insulin secretion in differentiated beta cells from mouse embryonic stem cells

To investigate early insulin release (EIR) and late insulin release (LIR) upon glucose challenge as well as important insulin signaling factors in differentiated insulin-producing cells from embryonic stem cel...

Hua Li, Amy Lam, Ai-min Xu, Karen Sl Lam, Sookja Kim Chung in Acta Pharmacologica Sinica (2010)

Article

Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na⁺/K⁺-ATPase

To examine if steroid-like compounds found in many Chinese medicinal products conventionally used for the promotion of blood circulation may act as active components via the same molecular mechanism triggered ...

Ronald JY Chen, Tse-yu Chung, Feng-yin Li, Wei-hung Yang… in Acta Pharmacologica Sinica (2010)

Article

Magnesium lithospermate B extracted from Salvia miltiorrhiza elevats intracellular Ca²⁺ level in SH-SY5Y cells

To examine if magnesium lithospermate B (MLB), a potent inhibitor of Na⁺/K⁺-ATPase, leads to the elevation of intracellular Ca²⁺ level as observed in cells treated with cardiac glycosides.

Yi-ching Chen, Tzyy-rong **n, Tse-yu Chung, Feng-yin Li… in Acta Pharmacologica Sinica (2010)

Article

Cannabidiol attenuates delayed-type hypersensitivity reactions via suppressing T-cell and macrophage reactivity

To investigate the effects cannabidiol (CBD) on delayed-type hypersensitivity (DTH) reactions and antigen-induced T-cell cytokine expression.

Der-zen Liu, Chieh-min Hu, Chung-hsiung Huang, Shiaw-pyng Wey… in Acta Pharmacologica Sinica (2010)

Article

Upregulation of NF-E2-related factor-2-dependent glutathione by carnosol provokes a cytoprotective response and enhances cell survival

To explore whether glutathione (GSH) increased through Nrf-2 activation is involved in the cytoprotective effects of carnosol in HepG2 cells.

Chien-chung Chen, Hui-ling Chen, Chia-wen Hsieh, Yi-ling Yang… in Acta Pharmacologica Sinica (2011)

Article

Active ingredients in Chinese medicines promoting blood circulation as Na⁺/K⁺-ATPase inhibitors

The positive inotropic effect of cardiac glycosides lies in their reversible inhibition on the membrane-bound Na⁺/K⁺-ATPase in human myocardium. Steroid-like compounds containing a core structure similar to cardi...

Ronald JY Chen, Tzyy-rong **n, Yi-ching Chen, Tse-yu Chung… in Acta Pharmacologica Sinica (2011)

Article

Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics

CYP2C9 enzyme metabolizes numerous clinically important drugs. The aim of this study is to investigate the frequencies of CYP2C9 genotypes and the effects of selected alleles on losartan pharmacokinetics in a lar...

Jung-woo Bae, Chang-ik Choi, Mi-jeong Kim, Da-hee Oh… in Acta Pharmacologica Sinica (2011)

Article

[6]-Shogaol inhibits melanogenesis in B16 mouse melanoma cells through activation of the ERK pathway

To investigate the effect of [6]-shogaol, an active ingredient in ginger, on melanogenesis and the underlying mechanisms.

Cheng Yao, Jang-hee Oh, Inn Gyung Oh, Chi-hyun Park… in Acta Pharmacologica Sinica (2013)

Article

Enhancing the potency of lithospermate B for inhibiting Na⁺/K⁺-ATPase activity by forming transition metal ion complexes

To determine whether replacing Mg²⁺ in magnesium lithospermate B (Mg-LSB) isolated from danshen (Salvia miltiorrhiza) with other metal ions could affect its potency in inhibition of Na⁺/K⁺-ATPase activity.

Nan-Hei Lin, Tse-Yu Chung, Feng-Yin Li, Hsin-An Chen… in Acta Pharmacologica Sinica (2013)