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Article
Open AccessA disease-associated gene desert directs macrophage inflammation through ETS2
Increasing rates of autoimmune and inflammatory disease present a burgeoning threat to human health1. This is compounded by the limited efficacy of available treatments1 and high failure rates during drug develop...
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Article
Open AccessUnique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis
Spondyloarthritis encompasses a group of common inflammatory diseases thought to be driven by IL-17A-secreting type-17 lymphocytes. Here we show increased numbers of GM-CSF-producing CD4 and CD8 lymphocytes in...
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Article
Anterior uterocervical angle measurement improves prediction of cerclage failure
To compare the anterior uterocervical angle and cervical length as predictors of spontaneous preterm delivery in patients with transvaginal cerclage.
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Article
Open AccessInvestigation of a possible extended risk haplotype in the IL23R region associated with ankylosing spondylitis
The IL23R region on chromosome 1 exhibits complex associations with ankylosing spondylitis (AS). We used publicly available epigenomic information and historical genetic association data to identify a putative re...
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Article
Open AccessErratum: A functional AT/G polymorphism in the 5′-untranslated region of SETDB2 in the IgE locus on human chromosome 13q14
Correction to: Genes and Immunity (2015) 16, 488–494; doi:10.1038/gene.2015.36; published online 17 September 2015 Updated online 12 May 2016: This article was originally published under a CC BY-NC-SA 4.0 lice...
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Open AccessA functional AT/G polymorphism in the 5′-untranslated region of SETDB2 in the IgE locus on human chromosome 13q14
The immunoglobulin E (IgE)-associated locus on human chromosome 13q14 influencing asthma-related traits contains the genes PHF11 and SETDB2. SETDB2 is located in the same linkage disequilibrium region as PHF11 an...
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Article
Open AccessTranscriptional repression and DNA loo** associated with a novel regulatory element in the final exon of the lymphotoxin-β gene
Transcriptional regulation has a critical role in the coordinate and context-specific expression of a cluster of genes encoding members of the tumour necrosis factor (TNF) superfamily found at chromosome 6p21,...
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Article
Regulation of major histocompatibility complex class II gene expression, genetic variation and disease
Major histocompatibility complex (MHC) class II molecules are central to adaptive immune responses and maintenance of self-tolerance. Since the early 1970s, the MHC class II region at chromosome 6p21 has been ...
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Article
Hollow-core photonic crystal fibres for delivery and compression of ultrashort optical pulses
We describe the use of tapered hollow-core photonic crystal fibres for delivery and compression of ultrashort optical pulses. We demonstrate delivery of transform-limited pulses with less than 100 fs pulse len...
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Article
Field enhancement within an optical fibre with a subwavelength air core
Tightly confined light enables a variety of applications ranging from nonlinear light management to atomic manipulation. Photonic-crystal fibres (PCFs) can provide strong guidance in very small cores while sim...
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Article
Stimulated Brillouin scattering from multi-GHz-guided acoustic phonons in nanostructured photonic crystal fibres
Wavelength-scale periodic microstructuring dramatically alters the optical properties of materials. An example is glass photonic crystal fibre1 (PCF), which guides light by means of a lattice of hollow micro/nano...
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Article
Control of dispersion in photonic crystal fibers
Photonic crystal fibers (PCFs) exploit the large index difference between air and glass to achieve modal properties unattainable by conventional fiber techniques.
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Article
Compact, stable and efficient all-fibre gas cells using hollow-core photonic crystal fibres
Gas-phase lasers small enough to fit in a credit card or hand-held laser pointer could soon become a reality. A hollow-core photonic crystal fibre based gas cell has been developed, containing a tenth of a mic...
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Article
Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility
Interleukin-8 (IL-8) has been implicated in the pathogenesis of RSV-induced bronchiolitis. Previously, we have described an association between bronchiolitis disease severity and a specific IL-8 haplotype comp...
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Article
Maximization of supercontinua in photonic crystal fibers by using double pulses and polarization effects
We show with sub-20 fs pulses both experimentally and theoretically two techniques to control the width and polarization of spectral supercontinua generated in photonic crystal fibers. The first exploits doubl...
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Article
Transformation and control of ultra-short pulses in dispersion-engineered photonic crystal fibres
Photonic crystal fibres (PCFs) offer greatly enhanced design freedom compared to standard optical fibres. For example, they allow precise control of the chromatic dispersion (CD) profile—the frequency dependen...
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Article
Predator-Mediated Coexistence of Exotic and Native Crustaceans in a Freshwater Lake?
The predatory effects of a Dipteran insect, Chaoborus, on the competition between exotic cladoceran Daphnia lumholtzi and two natives, D. catawba and D. pulex, were studied for a period of three years in a freshw...
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Article
Absolute frequency measurement of iodine lines with a femtosecond optical synthesizer
We have used a single laser femtosecond optical frequency synthesizer together with a widely tunable Nd:YAG laser to measure the absolute frequency of several absorption lines in molecular iodine around 532 nm...
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Article
Microstructured Silica as an Optical-Fiber Material
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Two Cases of Pulmonary Complications Associated with a Recently Recognised Salmonella enteritidis Phage Type, 21b, Affecting Immunocompetent Adults