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Article
Open AccessMap** a 50-spin-qubit network through correlated sensing
Spins associated to optically accessible solid-state defects have emerged as a versatile platform for exploring quantum simulation, quantum sensing and quantum communication. Pioneering experiments have shown ...
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Article
Open AccessVariation in human genes encoding adhesion and proinflammatory molecules are associated with severe malaria in the Vietnamese
The genetic basis for susceptibility to malaria has been studied widely in African populations but less is known of the contribution of specific genetic variants in Asian populations. We genotyped 67 single-nu...
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Article
Erratum: Interferon regulatory factor-1 polymorphisms are associated with the control of Plasmodium falciparum infection
Correction to: Genes and Immunity (2008) 9, 122–129; doi:10.1038/sj.gene.6364456 Since publication of this paper, the authors have noticed that E Sadighi Akha's name was published incorrectly. The correct name...
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Article
Variation in the ICAM1 gene is not associated with severe malaria phenotypes
Evidence from autopsy and in vitro binding studies suggests that adhesion of erythrocytes infected with Plasmodium falciparum to the human host intercellular adhesion molecule (ICAM)-1 receptor is important in th...
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Article
Interferon regulatory factor-1 polymorphisms are associated with the control of Plasmodium falciparum infection
We describe the haplotypic structure of the interferon regulatory factor-1 (IRF-1) locus in two West African ethnic groups, Fulani and Mossi, that differ in their susceptibility and immune response to Plasmodium ...
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Article
Haplotypic diversity in human CEACAM genes: effects on susceptibility to meningococcal disease
Adhesion between the opacity-associated adhesin (Opa) proteins of Neisseria meningitidis and human carcino-embryonic antigen cell adhesion molecule (CEACAM) proteins is an important stage in the pathogenesis of m...
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Article
Genetic variation at the TNF locus and the risk of severe sequelae of ocular Chlamydia trachomatis infection in Gambians
Tumor necrosis factor (TNF) is thought to be a key mediator of the inflammatory and fibrotic response to Chlamydia trachomatis (Ct) infection. A large matched-pair case–control study investigated putative functio...
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Article
Risk of trachomatous scarring and trichiasis in Gambians varies with SNP haplotypes at the interferon-gamma and interleukin-10 loci
Experimental evidence implicates interferon gamma (IFNγ) in protection from and resolution of chlamydial infection. Conversely, interleukin 10 (IL10) is associated with susceptibility and persistence of infect...
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Article
Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility
Interleukin-8 (IL-8) has been implicated in the pathogenesis of RSV-induced bronchiolitis. Previously, we have described an association between bronchiolitis disease severity and a specific IL-8 haplotype comp...
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Article
Complex haplotypic structure of the central MHC region flanking TNF in a West African population
TNF polymorphisms have been associated with susceptibility to malaria and other infectious and inflammatory conditions. We investigated a sample of 150 West African chromosomes to determine linkage disequilibrium...
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Article
Haplotypic relationship between SNP and microsatellite markers at the NOS2A locus in two populations
The density of genetic markers required for successful association map** of complex diseases depends on linkage disequilibrium (LD) between non-functional markers and functional variants. The haplotypic rela...
