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  1. No Access

    Article

    Revisiting the T-cell receptor alpha/delta locus and possible associations with multiple sclerosis

    A role for T cells in the pathogenesis of multiple sclerosis (MS) is well supported, evidenced by myriad immunological studies, as well as the unequivocal genetic influence of the major histocompatibility comp...

    C T Watson, A E Para, M R Lincoln, S V Ramagopalan, S M Orton… in Genes & Immunity (2011)

  2. No Access

    Article

    Regulation of major histocompatibility complex class II gene expression, genetic variation and disease

    Major histocompatibility complex (MHC) class II molecules are central to adaptive immune responses and maintenance of self-tolerance. Since the early 1970s, the MHC class II region at chromosome 6p21 has been ...

    L Handunnetthi, S V Ramagopalan, G C Ebers, J C Knight in Genes & Immunity (2010)

  3. No Access

    Article

    Analysis of 45 candidate genes for disease modifying activity in multiple sclerosis

    Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for its variability in disease outcome. As little is conclusively known about MS disease mechanisms, we have s...

    S. V. Ramagopalan, G. C. DeLuca, K. M. Morrison, B. M. Herrera… in Journal of Neurology (2008)

  4. No Access

    Article

    EVI5 is a risk gene for multiple sclerosis

    HLA-DRB1 is the major locus associated with risk for multiple sclerosis (MS). A recent genome-wide study showed three additional single-nucleotide polymorphisms (SNPs), within the IL2RA and IL7RA genes respect...

    I A Hoppenbrouwers, Y S Aulchenko, G C Ebers, S V Ramagopalan… in Genes & Immunity (2008)

  5. No Access

    Article

    Molecular mechanisms of migraine?

    Migraine is a common debilitating neurological disease characterised by attacks of severe headache with or without preceding aura. Its aetiology remains elusive; however it is clear that an interplay of geneti...

    S. V. Ramagopalan, N. E. Ramscar, M. Z. Cader in Journal of Neurology (2007)

  6. No Access

    Article

    The role of hereditary spastic paraplegia related genes in multiple sclerosis

    Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for its variability in disease outcome. It has been observed that axonal loss in MS is significant and that ir...

    G. C. DeLuca, S. V. Ramagopalan, M. Z. Cader, D. A. Dyment… in Journal of Neurology (2007)

  7. No Access

    Article

    Follow-up investigation of 12 proposed linkage regions in multiple sclerosis

    Multiple sclerosis (MS) is an autoimmune disease with overwhelming evidence for genetic determination, and for which a maternal parent-of-origin effect has been reported. As with many complex diseases, multipl...

    B M Herrera, M Z Cader, D A Dyment, J T Bell, S V Ramagopalan… in Genes & Immunity (2006)