-
Article
Open AccessReversal of MYB-dependent suppression of MAFB expression overrides leukaemia phenotype in MLL-rearranged AML
The transcription factor MYB plays a pivotal role in haematopoietic homoeostasis and its aberrant expression is involved in the genesis and maintenance of acute myeloid leukaemia (AML). We have previously demo...
-
Article
Open AccessAuthor Correction: High WBP5 expression correlates with elevation of HOX genes levels and is associated with inferior survival in patients with acute myeloid leukaemia
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Open AccessHigh WBP5 expression correlates with elevation of HOX genes levels and is associated with inferior survival in patients with acute myeloid leukaemia
WW domain binding protein 5 (WBP5), also known as Transcriptional Elongation Factor A like 9 (TCEAL9) has been proposed as a candidate oncogene for human colorectal cancers with microsatellite instability and ...
-
Article
Open AccessAuthor Correction: Yolk sac macrophage progenitors traffic to the embryo during defined stages of development
This article contains errors in Figs. 5 and 6, for which we apologize. In Fig. 5f, the image ‘E12.5 tail’ was inadvertently replaced with a duplicate of the image ‘E12.5 trunk’ from the same panel. In Figure 6...
-
Article
Open AccessYolk sac macrophage progenitors traffic to the embryo during defined stages of development
Tissue macrophages in many adult organs originate from yolk sac (YS) progenitors, which invade the develo** embryo and persist by means of local self-renewal. However, the route and characteristics of YS mac...
-
Article
Transcriptional regulation of SPROUTY2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3
Myeloproliferative neoplasms (MPN), which overproduce blood cells in the bone marrow, have recently been linked with a genetically determined decrease in expression of the MYB transcription factor. Here, we us...
-
Article
Comparison of interactive voice response, patient mailing, and mailed registry to encourage screening for osteoporosis: a randomized controlled trial
Guidelines recommend screening for osteoporosis with bone mineral density (BMD) testing in menopausal women, particularly those with additional risk factors for fracture. Many eligible women remain unscreened....
-
Article
C/EBPα and MYB regulate FLT3 expression in AML
The interaction between the receptor FLT3 (FMS-like tyrosine kinase-3) and its ligand FL leads to crucial signalling during the early stages of the commitment of haematopoietic stem cells. Mutation or over-exp...
-
Article
Open AccessMYBL2 haploinsufficiency increases susceptibility to age-related haematopoietic neoplasia
The haematopoietic system is prone to age-related disorders ranging from deficits in functional blood cells to the development of neoplastic states. Such neoplasms often involve recurrent cytogenetic abnormali...
-
Article
Open AccessDistinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells
The proto-oncogenic protein c-Myb is an essential regulator of hematopoiesis and is frequently deregulated in hematological diseases such as lymphoma and leukemia. To gain insight into the mechanisms underlyin...
-
Article
Professor Alan M Gewirtz (1949–2010)
-
Article
Embryogenic tissue initiation and somatic embryogenesis in Fraser fir (Abies fraseir [Pursh] Poir.)
Embryogenic suspensor mass (ESM) was established from immature seeds of Fraser fir. The initiation frequency of ESM was dependent on genotype, collection time, medium, and plant growth regulators (PGR) used. T...
-
Article
Targeting an E2F site in the mouse genome prevents promoter silencing in quiescent and post-mitotic cells
Previous studies have shown that the cell cycle-regulated B-myb promoter contains a conserved E2F binding site that is critical for repressing transcription in quiescent cells. To investigate its significance for...
-
Article
Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility
Interleukin-8 (IL-8) has been implicated in the pathogenesis of RSV-induced bronchiolitis. Previously, we have described an association between bronchiolitis disease severity and a specific IL-8 haplotype comp...
-
Chapter and Conference Paper
Analysis of Erythroid Cell-Specific Gene Expression
The aim of our work is to elucidate the molecular mechanisms involved in the co-expression of the globin and non-globin genes during red blood cell differentiation. Our principal experimental strategy is to tr...
