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  1. Article

    Open Access

    A disease-associated gene desert directs macrophage inflammation through ETS2

    Increasing rates of autoimmune and inflammatory disease present a burgeoning threat to human health1. This is compounded by the limited efficacy of available treatments1 and high failure rates during drug develop...

    C. T. Stankey, C. Bourges, L. M. Haag, T. Turner-Stokes, A. P. Piedade… in Nature (2024)

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  2. Article

    Open Access

    Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis

    Spondyloarthritis encompasses a group of common inflammatory diseases thought to be driven by IL-17A-secreting type-17 lymphocytes. Here we show increased numbers of GM-CSF-producing CD4 and CD8 lymphocytes in...

    M. H. Al-Mossawi, L. Chen, H. Fang, A. Ridley, J. de Wit, N. Yager… in Nature Communications (2017)

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  3. No Access

    Article

    Anterior uterocervical angle measurement improves prediction of cerclage failure

    To compare the anterior uterocervical angle and cervical length as predictors of spontaneous preterm delivery in patients with transvaginal cerclage.

    J C Knight, E Tenbrink, J Sheng, A S Patil in Journal of Perinatology (2017)

  4. Article

    Open Access

    Investigation of a possible extended risk haplotype in the IL23R region associated with ankylosing spondylitis

    The IL23R region on chromosome 1 exhibits complex associations with ankylosing spondylitis (AS). We used publicly available epigenomic information and historical genetic association data to identify a putative re...

    A R Roberts, M Vecellio, A Cortes, J C Knight, C J Cohen… in Genes & Immunity (2017)

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  5. Article

    Open Access

    Erratum: A functional AT/G polymorphism in the 5′-untranslated region of SETDB2 in the IgE locus on human chromosome 13q14

    Correction to: Genes and Immunity (2015) 16, 488–494; doi:10.1038/gene.2015.36; published online 17 September 2015 Updated online 12 May 2016: This article was originally published under a CC BY-NC-SA 4.0 lice...

    R J Holt, C Vandiedonck, S A Willis-Owen, J C Knight, W O Cookson… in Genes & Immunity (2017)

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  6. Article

    Open Access

    A functional AT/G polymorphism in the 5′-untranslated region of SETDB2 in the IgE locus on human chromosome 13q14

    The immunoglobulin E (IgE)-associated locus on human chromosome 13q14 influencing asthma-related traits contains the genes PHF11 and SETDB2. SETDB2 is located in the same linkage disequilibrium region as PHF11 an...

    R J Holt, C Vandiedonck, S A Willis-Owen, J C Knight, W O Cookson… in Genes & Immunity (2015)

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  7. Article

    Open Access

    Transcriptional repression and DNA loo** associated with a novel regulatory element in the final exon of the lymphotoxin-β gene

    Transcriptional regulation has a critical role in the coordinate and context-specific expression of a cluster of genes encoding members of the tumour necrosis factor (TNF) superfamily found at chromosome 6p21,...

    K Wicks, J C Knight in Genes & Immunity (2011)

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  8. No Access

    Article

    Regulation of major histocompatibility complex class II gene expression, genetic variation and disease

    Major histocompatibility complex (MHC) class II molecules are central to adaptive immune responses and maintenance of self-tolerance. Since the early 1970s, the MHC class II region at chromosome 6p21 has been ...

    L Handunnetthi, S V Ramagopalan, G C Ebers, J C Knight in Genes & Immunity (2010)

  9. No Access

    Article

    Hollow-core photonic crystal fibres for delivery and compression of ultrashort optical pulses

    We describe the use of tapered hollow-core photonic crystal fibres for delivery and compression of ultrashort optical pulses. We demonstrate delivery of transform-limited pulses with less than 100 fs pulse len...

    J. C. Knight, F. Gérôme, W. J. Wadsworth in Optical and Quantum Electronics (2007)

  10. No Access

    Article

    Field enhancement within an optical fibre with a subwavelength air core

    Tightly confined light enables a variety of applications ranging from nonlinear light management to atomic manipulation. Photonic-crystal fibres (PCFs) can provide strong guidance in very small cores while sim...

    G. S. Wiederhecker, C. M. B. Cordeiro, F. Couny, F. Benabid… in Nature Photonics (2007)

  11. Article

    Stimulated Brillouin scattering from multi-GHz-guided acoustic phonons in nanostructured photonic crystal fibres

    Wavelength-scale periodic microstructuring dramatically alters the optical properties of materials. An example is glass photonic crystal fibre1 (PCF), which guides light by means of a lattice of hollow micro/nano...

    P. Dainese, P. St. J. Russell, N. Joly, J. C. Knight, G. S. Wiederhecker… in Nature Physics (2006)

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  12. No Access

    Article

    Control of dispersion in photonic crystal fibers

    Photonic crystal fibers (PCFs) exploit the large index difference between air and glass to achieve modal properties unattainable by conventional fiber techniques.

    P.J. Roberts, B.J. Mangan, H. Sabert… in Journal of Optical and Fiber Communication… (2005)

  13. No Access

    Article

    Compact, stable and efficient all-fibre gas cells using hollow-core photonic crystal fibres

    Gas-phase lasers small enough to fit in a credit card or hand-held laser pointer could soon become a reality. A hollow-core photonic crystal fibre based gas cell has been developed, containing a tenth of a mic...

    F. Benabid, F. Couny, J. C. Knight, T. A. Birks, P. St J. Russell in Nature (2005)

  14. No Access

    Article

    Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility

    Interleukin-8 (IL-8) has been implicated in the pathogenesis of RSV-induced bronchiolitis. Previously, we have described an association between bronchiolitis disease severity and a specific IL-8 haplotype comp...

    D Hacking, J C Knight, K Rockett, H Brown, J Frampton, D P Kwiatkowski… in Genes & Immunity (2004)

  15. No Access

    Article

    Maximization of supercontinua in photonic crystal fibers by using double pulses and polarization effects

    We show with sub-20 fs pulses both experimentally and theoretically two techniques to control the width and polarization of spectral supercontinua generated in photonic crystal fibers. The first exploits doubl...

    V.L. Kalashnikov, P. Dombi, T. Fuji, W.J. Wadsworth, J.C. Knight… in Applied Physics B (2003)

  16. No Access

    Article

    Transformation and control of ultra-short pulses in dispersion-engineered photonic crystal fibres

    Photonic crystal fibres (PCFs) offer greatly enhanced design freedom compared to standard optical fibres. For example, they allow precise control of the chromatic dispersion (CD) profile—the frequency dependen...

    W. H. Reeves, D. V. Skryabin, F. Biancalana, J. C. Knight, P. St. J. Russell… in Nature (2003)

  17. No Access

    Article

    Predator-Mediated Coexistence of Exotic and Native Crustaceans in a Freshwater Lake?

    The predatory effects of a Dipteran insect, Chaoborus, on the competition between exotic cladoceran Daphnia lumholtzi and two natives, D. catawba and D. pulex, were studied for a period of three years in a freshw...

    K. Çelik, J.E. Schindler, W.J. Foris, J.C. Knight in Biological Invasions (2002)

  18. No Access

    Article

    Absolute frequency measurement of iodine lines with a femtosecond optical synthesizer

    We have used a single laser femtosecond optical frequency synthesizer together with a widely tunable Nd:YAG laser to measure the absolute frequency of several absorption lines in molecular iodine around 532 nm...

    R. Holzwarth, A.Yu. Nevsky, M. Zimmermann, Th. Udem, T.W. Hänsch… in Applied Physics B (2001)

  19. No Access

    Article

    Microstructured Silica as an Optical-Fiber Material

    J. C. Knight, T. A. Birks, B. J. Mangan, P. St. J. Russell in MRS Bulletin (2001)

  20. No Access

    Article

    Two Cases of Pulmonary Complications Associated with a Recently Recognised Salmonella enteritidis Phage Type, 21b, Affecting Immunocompetent Adults

    J. C. Knight, M. Knight, M. J. Smith in European Journal of Clinical Microbiology … (2000)

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