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Article
Open AccessA CRISPR-Cas9 screen identifies EXO1 as a formaldehyde resistance gene
Fanconi Anemia (FA) is a rare, genome instability-associated disease characterized by a deficiency in repairing DNA crosslinks, which are known to perturb several cellular processes, including DNA transcriptio...
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Protocol
Comprehensive Interactome Map** of Nuclear Receptors Using Proximity Biotinylation
Nuclear receptors, including hormone receptors, perform their cellular activities by modulating their protein–protein interactions. They engage with specific ligands and translocate to the nucleus, where they ...
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Article
Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency
Modulation of DNA repair pathway choice by a potent inhibitor of 53BP1 improves the efficiency of homology-dependent genome editing in human and mouse cells.
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Article
The structural basis of modified nucleosome recognition by 53BP1
A cryo-electron microscopy structure of the DNA damage repair protein 53BP1 bound to a nucleosome illuminates the way 53BP1 recognizes two types of histone modifications (a methyl group and a ubiquitin moiety)...
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Protocol
A Quantitative and High-Throughput Assay of Human Papillomavirus DNA Replication
Replication of the human papillomavirus (HPV) double-stranded DNA genome is accomplished by the two viral proteins E1 and E2 in concert with host DNA replication factors. HPV DNA replication is an established ...
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Protocol
Methods to Assess the Nucleocytoplasmic Shuttling of the HPV E1 Helicase and Its Effects on Cellular Proliferation and Induction of a DNA Damage Response
Replication of the human papillomavirus (HPV) double-stranded DNA genome in the nucleus of infected cells relies on the viral proteins E1 and E2 in conjunction with the host DNA replication machinery. This pro...
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Article
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark
53BP1 (also called TP53BP1) is a chromatin-associated factor that promotes immunoglobulin class switching and DNA double-strand-break (DSB) repair by non-homologous end joining. To accomplish its function in D...