Skip to main content

3 Result(s)

within Alana Sherker Remove this filter

and

  1. No Access

    Article

    The shieldin complex mediates 53BP1-dependent DNA repair

    53BP1 is a chromatin-binding protein that regulates the repair of DNA double-strand breaks by suppressing the nucleolytic resection of DNA termini1,2. This function of 53BP1 requires interactions with PTIP3 and R...

    Sylvie M. Noordermeer, Salomé Adam, Dheva Setiaputra, Marco Barazas… in Nature (2018)

  2. No Access

    Article

    The structural basis of modified nucleosome recognition by 53BP1

    A cryo-electron microscopy structure of the DNA damage repair protein 53BP1 bound to a nucleosome illuminates the way 53BP1 recognizes two types of histone modifications (a methyl group and a ubiquitin moiety)...

    Marcus D. Wilson, Samir Benlekbir, Amélie Fradet-Turcotte, Alana Sherker… in Nature (2016)

  3. No Access

    Article

    A mechanism for the suppression of homologous recombination in G1 cells

    A mechanism for the repression of homologous recombination in G1, the stage of the cell cycle preceding replication, is determined; the critical aspects are the interaction between BRCA1 and PALB2–BRCA2, and s...

    Alexandre Orthwein, Sylvie M. Noordermeer, Marcus D. Wilson, Sébastien Landry… in Nature (2015)