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Article
Open AccessThe PML1-WDR5 axis regulates H3K4me3 marks and promotes stemness of estrogen receptor-positive breast cancer
The alternative splicing of PML precursor mRNA gives rise to various PML isoforms, yet their expression profile in breast cancer cells remains uncharted. We discovered that PML1 is the most abundant isoform in al...
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Article
Comprehensive characterization of protein–protein interactions perturbed by disease mutations
Technological and computational advances in genomics and interactomics have made it possible to identify how disease mutations perturb protein–protein interaction (PPI) networks within human cells. Here, we sh...
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Article
Open AccessKLF4 defines the efficacy of the epidermal growth factor receptor inhibitor, erlotinib, in triple-negative breast cancer cells by repressing the EGFR gene
Triple-negative breast cancer (TNBC) is characterized by high rates of recurrence and poor overall survival. This is due, in part, to a deficiency of targeted therapies, making it essential to identify therape...
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Article
Expression of LC3B and FIP200/Atg17 in brain metastases of breast cancer
Macroautophagy/autophagy is considered to play key roles in tumor cell evasion of therapy and establishment of metastases in breast cancer. High expression of LC3, a residual autophagy marker, in primary breas...
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Article
Open AccessFollistatin is a metastasis suppressor in a mouse model of HER2-positive breast cancer
Follistatin (FST) is an intrinsic inhibitor of activin, a member of the transforming growth factor-β superfamily of ligands. The prognostic value of FST and its family members, the follistatin-like (FSTL) prot...
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Article
Open AccessMutant p53 dictates the oncogenic activity of c-Abl in triple-negative breast cancers
We recently established c-Abl as a potent suppressor of triple-negative breast cancer (TNBC) progression through its reactivation of a p53:p21 signaling axis coupled to senescence. Moreover, we observed co-exp...
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Article
Open AccessHotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome
In addition to mutations in genes, aberrant enhancer element activity at non-coding regions of the genome is a key driver of tumorigenesis. Here, we perform epigenomic enhancer profiling of a cohort of more th...
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Article
Open AccessBioengineering of Tobacco Mosaic Virus to Create a Non-Infectious Positive Control for Ebola Diagnostic Assays
The 2014 Ebola epidemic is the largest to date. There is no cure or treatment for this deadly disease; therefore there is an urgent need to develop new diagnostics to accurately detect Ebola. Current RT-PCR as...
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Article
Supplemental Online Pharmacology Modules Increase Recognition and Production Memory in a Hybrid Problem-Based Learning (PBL) Curriculum
Problem-based learning (PBL) presents unique challenges to longitudinal disciplines such as pharmacology. A curricular supplement (PharmWeb) was created to increase pharmacology knowledge, increase surface lea...
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Article
Hypomethylation of the MMP7 promoter and increased expression of MMP7 distinguishes the basal-like breast cancer subtype from other triple-negative tumors
Identification of novel targets for the treatment of basal-like breast cancer is essential for improved outcomes in patients with this disease. This study investigates the association of MMP7 expression and MMP7 ...
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Article
On-Command Drug Release from Nanochains Inhibits Growth of Breast Tumors
To evaluate the ability of radiofrequency (RF)-triggered drug release from a multicomponent chain-shaped nanoparticle to inhibit the growth of an aggressive breast tumor.
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Article
Open AccessIntrinsic bias in breast cancer gene expression data sets
While global breast cancer gene expression data sets have considerable commonality in terms of their data content, the populations that they represent and the data collection methods utilized can be quite disp...
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Article
Open AccessCell cycle correlated genes dictate the prognostic power of breast cancer gene lists
Numerous gene lists or "classifiers" have been derived from global gene expression data that assign breast cancers to good and poor prognosis groups. A remarkable feature of these molecular signatures is that ...
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Article
Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-β signaling in ErbB2/Neu-induced tumors from transgenic mice
Upregulation of HER2/ErbB2/Neu occurs in 15–30% of human breast cancers and correlates with poor prognosis. Identification of ErbB2/Neu transcriptional targets should facilitate development of novel therapeuti...
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Article
High levels of luteinizing hormone analog stimulate gonadal and adrenal tumorigenesis in mice transgenic for the mouse inhibin-α-subunit promoter/Simian virus 40 T-antigen fusion gene
Transgenic (TG) mice expressing the Simian virus 40 T-antigen under the control of the murine inhibin-α promoter (Inhα/Tag) develop granulosa and Leydig cell tumors at the age of 5–6 months, with 100% penetrance....
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Chapter
LH Hypersecreting Mice: A Model for Ovarian Granulosa Cell Tumors
Proper function of the ovary requires carefully orchestrated proliferation and differentiation of granulosa cells that respond dynamically to signals from LH and FSH, and a host of other paracrine and autocrin...
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Chapter
Estradiol Inhibition of Expression of the Human Glycoprotein Hormone α-Subunit Gene Through an ERE-Independent Mechanism
The α-subunit comprises one-half of all glycoprotein hormones. Expression of the α-subunit gene occurs in a variety of cell types (gonadotrophs, thyrotrophs, and syncytiotrophoblasts) and is regulated by a mul...
