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  1. No Access

    Article

    Epigenetic alterations identify a confluence of genetic vulnerabilities tied to opioid overdose

    An T. Hoang, Olivia Corradin in Neuropsychopharmacology (2024)

  2. No Access

    Article

    Convergence of case-specific epigenetic alterations identify a confluence of genetic vulnerabilities tied to opioid overdose

    Opioid use disorder is a highly heterogeneous disease driven by a variety of genetic and environmental risk factors which have yet to be fully elucidated. Opioid overdose, the most severe outcome of opioid use...

    Olivia Corradin, Richard Sallari, An T. Hoang, Bibi S. Kassim… in Molecular Psychiatry (2022)

  3. Article

    Correction: Publisher Correction: ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters

    Nature Communications 6: Article number: 6186 (2015); Published: 3 February 2015; Updated: 10 April 2018 The original HTML version of this Article had an incorrect volume number of 2; it should have been 6. Th...

    Swneke D. Bailey, **aoyang Zhang, Kinjal Desai, Malika Aid… in Nature Communications (2018)

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  4. Article

    Open Access

    Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome

    In addition to mutations in genes, aberrant enhancer element activity at non-coding regions of the genome is a key driver of tumorigenesis. Here, we perform epigenomic enhancer profiling of a cohort of more th...

    Andrea J. Cohen, Alina Saiakhova, Olivia Corradin… in Nature Communications (2017)

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  5. No Access

    Article

    Modeling disease risk through analysis of physical interactions between genetic variants within chromatin regulatory circuitry

    Peter Scacheri and colleagues identify ‘outside’ SNPs that physically interact with GWAS risk SNPs as part of a target gene's regulatory circuitry. Their findings suggest a model whereby outside variants and G...

    Olivia Corradin, Andrea J Cohen, Jennifer M Luppino, Ian M Bayles… in Nature Genetics (2016)

  6. No Access

    Article

    ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters

    Chromatin interactions connect distal regulatory elements to target gene promoters guiding stimulus- and lineage-specific transcription. Few factors securing chromatin interactions have so far been identified....

    Swneke D. Bailey, **aoyang Zhang, Kinjal Desai, Malika Aid… in Nature Communications (2015)

  7. Article

    Open Access

    Enhancer variants: evaluating functions in common disease

    Gene enhancer elements are noncoding segments of DNA that play a central role in regulating transcriptional programs that control development, cell identity, and evolutionary processes. Recent studies have sho...

    Olivia Corradin, Peter C Scacheri in Genome Medicine (2014)

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