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Article
Open AccessThe small G-protein RalA promotes progression and metastasis of triple-negative breast cancer
Breast cancer (BC) is the most common cancer in women and the leading cause of cancer-associated mortality in women. In particular, triple-negative BC (TNBC) has the highest rate of mortality due in large part...
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Article
Open AccessGenomic features of rapid versus late relapse in triple negative breast cancer
Triple-negative breast cancer (TNBC) is a heterogeneous disease and we have previously shown that rapid relapse of TNBC is associated with distinct sociodemographic features. We hypothesized that rapid versus ...
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Article
Open AccessNEDD4 expression is associated with breast cancer progression and is predictive of a poor prognosis
A role for neural precursor cell-expressed developmentally downregulated gene 4 (NEDD4) in tumorigenesis has been suggested. However, information is lacking on its role in breast tumor biology. The purpose of ...
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Article
Open AccessPyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repair
Resistance to genotoxic therapies is a primary cause of treatment failure and tumor recurrence. The underlying mechanisms that activate the DNA damage response (DDR) and allow cancer cells to escape the lethal...
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Article
Open AccessStromal PTEN determines mammary epithelial response to radiotherapy
The importance of the tumor–associated stroma in cancer progression is clear. However, it remains uncertain whether early events in the stroma are capable of initiating breast tumorigenesis. Here, we show that...
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Article
Open AccessFollistatin is a metastasis suppressor in a mouse model of HER2-positive breast cancer
Follistatin (FST) is an intrinsic inhibitor of activin, a member of the transforming growth factor-β superfamily of ligands. The prognostic value of FST and its family members, the follistatin-like (FSTL) prot...
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Article
Hypomethylation of the MMP7 promoter and increased expression of MMP7 distinguishes the basal-like breast cancer subtype from other triple-negative tumors
Identification of novel targets for the treatment of basal-like breast cancer is essential for improved outcomes in patients with this disease. This study investigates the association of MMP7 expression and MMP7 ...
